Author Response: Test–Retest Reliability of Hemifield, Central-Field, and Full-Field Chromatic Pupillometry for Assessing the Function of Melanopsin-Containing Retinal Ganglion Cells

2015 ◽  
Vol 56 (4) ◽  
pp. 2520
Author(s):  
Shaobo Lei ◽  
Herbert C. Goltz ◽  
Manokaraananthan Chandrakumar ◽  
Agnes M. F. Wong
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Author Response ◽  
Central Field ◽  
Retinal Ganglion ◽  
Retest Reliability ◽  
Full Field ◽  
Response Test ◽  
Chromatic Pupillometry ◽  
Test Retest Reliability

Properties of stimulus-dependent synchrony in retinal ganglion cells

2007 ◽  
Vol 24 (6) ◽  
pp. 827-843 ◽  
Author(s):  
SUSMITA CHATTERJEE ◽  
DAVID K. MERWINE ◽  
FRANKLIN R. AMTHOR ◽  
NORBERTO M. GRZYWACZ
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cells ◽  
Functional Role ◽  
Ganglion Cells ◽  
Receptive Fields ◽  
Rabbit Retina ◽  
Retinal Ganglion ◽  
Spike Synchrony ◽  
Full Field ◽  
Dependent Correlation

Neighboring retinal ganglion cells often spike synchronously, but the possible function and mechanism of this synchrony is unclear. Recently, the strength of the fast correlation between ON-OFF directionally selective cells of the rabbit retina was shown to be stimulus dependent. Here, we extend that study, investigating stimulus-dependent correlation among multiple ganglion-cell classes, using multi-electrode recordings. Our results generalized those for directionally selective cells. All cell pairs exhibiting significant spike synchrony did it for an extended edge but rarely for full-field stimuli. The strength of this synchrony did not depend on the amplitude of the response and correlations could be present even when the cells' receptive fields did not overlap. In addition, correlations tended to be orientation selective in a manner predictable by the relative positions of the receptive fields. Finally, extended edges and full-field stimuli produced significantly greater and smaller correlations than predicted by chance respectively. We propose an amacrine-network model for the enhancement and depression of correlation. Such an apparently purposeful control of correlation adds evidence for retinal synchrony playing a functional role in vision.

scholarly journals Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells

2012 ◽  
Vol 520 (17) ◽  
pp. 4032-4049 ◽  
Author(s):  
Genki Ogata ◽  
Tyler W. Stradleigh ◽  
Gloria J. Partida ◽  
Andrew T. Ishida
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Full Field ◽  
Adult Rat

scholarly journals Author response: Reconstruction of natural images from responses of primate retinal ganglion cells

2020 ◽  
Author(s):  
Nora Brackbill ◽  
Colleen Rhoades ◽  
Alexandra Kling ◽  
Nishal P Shah ◽  
Alexander Sher ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Natural Images ◽  
Author Response ◽  
Retinal Ganglion ◽  
Response Reconstruction

The effects of histamine on rat and monkey retinal ganglion cells

2004 ◽  
Vol 21 (6) ◽  
pp. 935-943 ◽  
Author(s):  
MATTHEW J. GASTINGER ◽  
RAFAIL G. YUSUPOV ◽  
RANDOLPH D. GLICKMAN ◽  
DAVID W. MARSHAK
Keyword(s):  
Firing Rate ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Histamine Receptor ◽  
Receptor Subtypes ◽  
Retinal Ganglion ◽  
Full Field ◽  
Light Stimuli ◽  
Evoked Activity

Mammalian retinas receive input from the posterior hypothalamus, and the neurotransmitter in this pathway is histamine. To determine whether histamine influences ganglion cells, we analyzed the effects of histamine on their maintained and light-evoked activity in vitro. In monkeys, histamine increased the maintained firing rate in 42% of ganglion cells, decreased it in 38%, and had no effect in 20%. When histamine and the HR3 agonist, methylhistamine, were applied to the same cells in succession, their effects were sometimes different, a finding suggesting that at least one other histamine receptor is present. In addition, the responses of some ganglion cells to full-field light stimuli were decreased by histamine and methylhistamine. In rats, the effects of histamine were somewhat different. Histamine increased the maintained firing rate of 82% of ganglion cells. Methylhistamine and the HR2 agonist, dimaprit, had the same effects as histamine. In some cells, histamine increased the light responses, but in others it decreased them. Histamine had no effect on ganglion cells in either species when synaptic transmission was blocked by low Ca2+/high Mg2+ Ames medium. Thus, the major effects of histamine were on the maintained activity of retinal ganglion cells. In both rats and monkeys, 80% or more of the ganglion cells were affected by histamine, and these responses were mediated by at least two of the histamine receptor subtypes.

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