Cortical Activation During Cholinesterase-Inhibitor Treatment in Alzheimer Disease: Preliminary Findings From a Pharmaco-fMRI Study

Background/Aims: Hypocretin promotes wakefulness and modulates REM sleep. Alterations in the hypocretin system are increasingly implicated in dementia. We evaluated relationships among hypocretin, dementia biomarkers, and sleep symptoms in elderly participants, most of whom had dementia. Methods: One-hundred twenty-six adults (mean age 66.2 ± 8.4 years) were recruited from the Emory Cognitive Clinic. Diagnoses were Alzheimer disease (AD; n = 60), frontotemporal dementia (FTD; n = 21), and dementia with Lewy bodies (DLB; n = 20). We also included cognitively normal controls (n = 25). Participants and/or caregivers completed sleep questionnaires and lumbar puncture was performed for cerebrospinal fluid (CSF) assessments. Results: Except for sleepiness (worst in DLB) and nocturia (worse in DLB and FTD) sleep symptoms did not differ by diagnosis. CSF hypocretin concentrations were available for 87 participants and normal in 70, intermediate in 16, and low in 1. Hypocretin levels did not differ by diagnosis. Hypocretin levels correlated with CSF total τ levels only in men (r = 0.34; p = 0.02). Lower hypocretin levels were related to frequency of nightmares (203.9 ± 29.8 pg/mL in those with frequent nightmares vs. 240.4 ± 46.1 pg/mL in those without; p = 0.05) and vivid dreams (209.1 ± 28.3 vs. 239.5 ± 47.8 pg/mL; p = 0.014). Cholinesterase inhibitor use was not associated with nightmares or vivid dreaming. Conclusion: Hypocretin levels did not distinguish between dementia syndromes. Disturbing dreams in dementia patients may be related to lower hypocretin concentrations in CSF.

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IC-P3-204: Effects of donepezil on cortical activation in MCI: A placebo controlled fMRI study

Alzheimer s & Dementia ◽

10.1016/j.jalz.2008.05.148 ◽

2008 ◽

Vol 4 ◽

pp. T88-T88

Author(s):

Jeffrey R. Petrella ◽

Steven E. Prince ◽

Sriyesh Krishnan ◽

Hala Husain ◽

Lisa Kelly ◽

...

Keyword(s):

Cortical Activation ◽

Fmri Study

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Neurolinguistics

Language Teaching ◽

10.1017/s0261444806304119 ◽

2007 ◽

Vol 40 (1) ◽

pp. 86-88

Keyword(s):

Los Angeles ◽

Brain Research ◽

Event Related Potential ◽

Cortical Activation ◽

Fmri Study ◽

Neuroimaging Data ◽

Interlingual Homographs ◽

L1 And L2 ◽

Phonological Complexity ◽

Cortical Activation Pattern

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