scholarly journals Effect of a three-piece inflatable penile prosthesis combined with a phosphodiesterase-5 inhibitor on erectile dysfunction

2021 ◽  
Vol 49 (4) ◽  
pp. 030006052098536
Author(s):  
Jian Wang ◽  
Peng Wu ◽  
Qiang Liu ◽  
Liangliang Ben ◽  
Geng Chen ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Adhesion Molecule ◽  
Erectile Function ◽  
Life Quality ◽  
Penile Prosthesis ◽  
Sexual Life ◽  
Controlled Study ◽  
Phosphodiesterase 5 Inhibitor ◽  
Inflatable Penile Prosthesis ◽  
Phosphodiesterase 5

Objective To investigate the therapeutic effect of implanting a three-piece inflatable penile prosthesis (IPP) combined with the phosphodiesterase-5 inhibitor sildenafil in severe erectile dysfunction (ED) patients. Methods This randomized controlled study included 123 ED patients. Sixty-two patients received the IPP implantation and 61 patients received the IPP implantation and the phosphodiesterase-5 inhibitor sildenafil. Erectile function and sexual life quality were evaluated using the five-item International Index of Erectile Function (IIEF) and modified Sexual Life Quality Questionnaire–Quality of Life domain (mSLQQ-QoL), respectively. Serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, vascular cell adhesion molecule (VCAM)-1, and intercellular adhesion molecule (ICAM)-1 levels were assessed. Kaplan–Meier curves were used to assess the overall IPP survival. Results Implantation of the three-piece IPP with sildenafil improved erectile function and sexual life quality, alleviated the inflammatory response, reduced the complication rate, and improved overall IPP survival. Conclusion Implantation of the three-piece IPP combined with a phosphodiesterase-5 inhibitor significantly improved clinical outcomes and the prognosis in ED patients.

scholarly journals A purely penoscrotal approach: Reservoir placement of an inflatable penile prosthesis (IPP) in an orthotopic neobladder patient. Case report

2019 ◽  
Vol 91 (3) ◽  
Author(s):  
Cumhur Yeşildal ◽  
Ahmet Tevfik Albayrak ◽  
Abdullah Hizir Yavuzsan ◽  
Musab Ilgi ◽  
Sinan Levent Kireççi
Keyword(s):  
Erectile Dysfunction ◽  
Perioperative Complications ◽  
Surgical Techniques ◽  
Penile Prosthesis ◽  
Orthotopic Neobladder ◽  
Medical Treatments ◽  
Inflatable Penile Prosthesis ◽  
Estimated Blood Loss ◽  
Phosphodiesterase 5 ◽  
Erectile Dysfunction Treatment

Introduction: The inflatable penile prosthesis (IPP) is the last step in drug-resistant erectile dysfunction treatment. IPP implantation can be challenging, especially following a cystoprostatectomy with an orthotopic neobladder. There is no consensus about surgical techniques for placement of an IPP reservoir in such patients. In this paper, we present a case of an IPP and reservoir placement with a single penoscrotal incision. Case: A 55-year-old patient, who underwent radical cysto-prostatectomy with an orthotopic neobladder seven years ago, presented with severe erectile dysfunction. His oncologic status was stable, and he was in remission. He also had high blood pressure and took medication for it. He previously used different medical treatments, such as oral phosphodiesterase-5 inhibitors (PDE5i), intraurethral prostaglandin E2 (PGE2) installations, and Trimix injections. As far as we know, he had no benefit from these treatments. A three-piece IPP was recom- mended. After a discussion of surgical techniques, we chose the penoscrotal approach, and the ectopic reservoir was placed through the inguinal canal, guided by a forefinger. Results: The total operative time was 60 minutes, and the estimated blood loss was minimal. There were no perioperative complications. The patient was discharged on postoperative day one. He could start to use the IPP in the first month. His sexual and urinary functions were normal, and there was no abdominal bulging from the ectopic reservoir at the three-month follow-up.Conclusions: In conclusion, ectopic placement of the reservoir through a single penoscrotal incision appears to be a safe and acceptable surgical technique for postoperative ED following a radical cystoprostatectomy with an orthotopic neobladder.

scholarly journals Patient’s satisfaction after 2-piece inflatable penile prosthesis implantation: An Italian multicentric study

2016 ◽  
Vol 88 (1) ◽  
pp. 1 ◽  
Author(s):  
Giorgio Gentile ◽  
Alessandro Franceschelli ◽  
Paolo Massenio ◽  
Agostino Tuccio ◽  
Andrea Cocci ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Penile Prosthesis ◽  
Functional Results ◽  
The Elderly ◽  
Sexual Life ◽  
Pelvic Surgery ◽  
Multicentric Study ◽  
Patient’S Satisfaction ◽  
Inflatable Penile Prosthesis

Introduction: Penile prosthesis implant represents a valuable solution for pts with severe erectile dysfunction (ED), non-responders to medical management. The aim of our study was to evaluate the satisfaction of patients (pts) after 2-pieces inflatable penile prosthesis (IPP). Aim of the study: to evaluate safety, reliability and post-operative patient’s satisfaction after implantation of two-pieces IPP. Materials and Methods: This retrospective multicentric analysis concerns a group of 42 patients undergone 2-pieces IPP implantation from November 2005 to November 2013, in four Centers of proven experience. As a first step, a detailed review of all clinical reports was performed. Secondly, every patient was asked to fill the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) specifically modified, in order to assess their own satisfaction after surgery and, its impact on patient’s quality of sexual life. Results: 42 pts were evaluated (AMS-Ambicor: 28; Coloplast- Excell: 14); mean age, at time of operation: 60,7 years; mean follow up: 27,6 months; etiology of ED: vascular 23,8%, diabetes 19%, La Peyronie D. 7,1%, consequence of radical prostatectomy 31%, consequence of other pelvic surgery 11,9%, spinal trauma 7%. Mean operative time: 117 ± 58 min, mean postoperative hospital stay 3 ± 1,6 days. Post operative short-term complications: 4 pts (9,5%). Post operative long-term complications: 4 pts (9,5%). Long-term functional results (Questionnaire): 71% of pts (30) reported regular use of the prosthesis, at least 1 time/week, the satisfaction was good in 42% of pts (18), quite good in 33,3% (14), quite bad in 2,4% (1), very bad in 7,1% (3), 6 pts (14,4%) didn’t answer. Conclusions: 2 pieces IPP appears to be associated with a low complication rate and good satisfaction of pts especially in the elderly. It also assures satisfactory rates of aesthetics and functional results.

Efficacy of Tadalafil in Men with Erectile Dysfunction Naïve to Phosphodiesterase 5 Inhibitor Therapy Compared with Prior Responders to Sildenafil Citrate

2006 ◽  
Vol 3 (4) ◽  
pp. 668-675 ◽  
Author(s):  
Gregory A. Broderick ◽  
Craig F. Donatucci ◽  
Dimitrios Hatzichristou ◽  
Luiz O. Torres ◽  
Luc Valiquette ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Inhibitor Therapy ◽  
Sildenafil Citrate ◽  
Phosphodiesterase 5 Inhibitor ◽  
Phosphodiesterase 5

Surgery for disorders of erectile function, ejaculation, and seminal vesicles

2020 ◽  
pp. 631-650
Author(s):  
Suzanne Biers ◽  
Noel Armenakas ◽  
Alastair Lamb ◽  
Stephen Mark ◽  
John Reynard ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Surgical Treatment ◽  
Vascular Surgery ◽  
Erectile Function ◽  
Penile Prosthesis ◽  
Seminal Vesicles ◽  
Peyronie’S Disease ◽  
Surgical Interventions ◽  
Peyronie's Disease

This chapter begins by covering the physiology of erections and ejaculation. It provides ways of evaluating erectile dysfunction and then surgical interventions, including vascular surgery and penile prosthesis. Finally, surgical treatment for Peyronie’s disease is covered.

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