High Performance Liquid Chromatographic Determination of Dothiepin and Northiaden in Human Plasma and Serum
1973 ◽
Vol 1
(2)
◽
pp. 387-390
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Keyword(s):
The Mean
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A method has been developed for the separation and measurement of dothiepin and the N-desmethyl metabolite, northiaden, in human plasma or serum by high performance liquid chromatography. The method uses a structurally-related drug, amitriptyline, as an internal standard and provides a limit of detection of about 10 ng/ml for each component. At a concentration of 20 ng/ml, northiaden and dothiepin could be measured within ±11% and ± 6% of the mean respectively and at 200 ng/ml within ± 3% and ± 1% of the mean. The method has been applied to the analysis of serum from patients undergoing dothiepin therapy.
2003 ◽
Vol 68
(11)
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pp. 883-892
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1983 ◽
Vol 29
(10)
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pp. 1840-1842
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1985 ◽
Vol 339
◽
pp. 359-365
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1991 ◽
Vol 558
(1)
◽
pp. 115-124
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High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma
1986 ◽
Vol 383
◽
pp. 449-455
1984 ◽
Vol 309
◽
pp. 222-224
1996 ◽
Vol 729
(1-2)
◽
pp. 259-266
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1998 ◽
Vol 714
(2)
◽
pp. 293-298
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