scholarly journals Impaired brainstem and thalamic high-frequency oscillatory EEG activity in migraine between attacks

Cephalalgia ◽  
2016 ◽  
Vol 37 (10) ◽  
pp. 915-926 ◽  
Author(s):  
Camillo Porcaro ◽  
Giorgio Di Lorenzo ◽  
Stefano Seri ◽  
Francesco Pierelli ◽  
Franca Tecchio ◽  
...  
Keyword(s):  
High Frequency ◽  
Age Of Onset ◽  
Oscillatory Activity ◽  
Separation Algorithm ◽  
Broadband Signal ◽  
Primary Determinant ◽  
Oscillatory Eeg ◽  
Somatosensory Pathway ◽  
The Right ◽  
High Frequency Oscillatory

Introduction We investigated whether interictal thalamic dysfunction in migraine without aura (MO) patients is a primary determinant or the expression of its functional disconnection from proximal or distal areas along the somatosensory pathway. Methods Twenty MO patients and twenty healthy volunteers (HVs) underwent an electroencephalographic (EEG) recording during electrical stimulation of the median nerve at the wrist. We used the functional source separation algorithm to extract four functionally constrained nodes (brainstem, thalamus, primary sensory radial, and primary sensory motor tangential parietal sources) along the somatosensory pathway. Two digital filters (1–400 Hz and 450–750 Hz) were applied in order to extract low- (LFO) and high- frequency (HFO) oscillatory activity from the broadband signal. Results Compared to HVs, patients presented significantly lower brainstem (BS) and thalamic (Th) HFO activation bilaterally. No difference between the two cortical HFO as well as in LFO peak activations between the two groups was seen. The age of onset of the headache was positively correlated with HFO power in the right brainstem and thalamus. Conclusions This study provides evidence for complex dysfunction of brainstem and thalamocortical networks under the control of genetic factors that might act by modulating the severity of migraine phenotype.

scholarly journals The role of high-frequency oscillatory activity in reward processing and learning

2015 ◽  
Vol 49 ◽  
pp. 1-7 ◽  
Author(s):  
Josep Marco-Pallarés ◽  
Thomas F. Münte ◽  
Antoni Rodríguez-Fornells
Keyword(s):  
High Frequency ◽  
Reward Processing ◽  
Oscillatory Activity ◽  
High Frequency Oscillatory

Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinsonʼs disease

Neuroreport ◽  
2009 ◽  
Vol 20 (17) ◽  
pp. 1549-1553 ◽  
Author(s):  
Abdoul Kane ◽  
William D. Hutchison ◽  
Mojgan Hodaie ◽  
Andres M. Lozano ◽  
Jonathan O. Dostrovsky
Keyword(s):  
Subthalamic Nucleus ◽  
High Frequency ◽  
Oscillatory Activity ◽  
High Frequency Oscillatory

Actions of excitatory amino acids on mesencephalic trigeminal neurons

1998 ◽  
Vol 76 (9) ◽  
pp. 900-908 ◽  
Author(s):  
Kenneth A Pelkey ◽  
Kenneth C Marshall
Keyword(s):  
High Frequency ◽  
Oscillatory Activity ◽  
Long Duration ◽  
Trigeminal Neurons ◽  
Glutamate Agonists ◽  
Selective Agonists ◽  
Mesencephalic Trigeminal Neurons ◽  
High Frequency Oscillatory ◽  
Kainate Excitotoxicity

Mesencephalic trigeminal (MeV) neurons are primary sensory neurons of which the cell soma is located within the brainstem, and is associated with synaptic contacts. In previous studies it has been reported that these cells are resistant to kainic acid excitotoxicity, and have little or no responsiveness to exogenously applied glutamate or selective agonists. In an in vitro slice preparation with intracellular recording, we have found that these cells respond to pressure-applied glutamate, N-methyl-D-aspartic acid (NMDA), kainate (KA), and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). The kainate and AMPA responses appear to be mediated by different receptors, at least in part, since they exhibit differing sensitivity to an AMPA receptor selective antagonist. The agonists generally evoke larger responses than glutamate and exhibit a long-duration desensitization requiring approximately 10 min for full recovery. Some cross-desensitization between the glutamate agonists is also observed. Mesencephalic trigeminal neurons exhibit high-frequency oscillatory activity during depolarizations that approach threshold potentials, and these could combine with transmitter-induced depolarizations to enhance the excitability of these cells. Previous reports of nonsensitivity to glutamate and to kainate excitotoxicity are attributable to relatively small responses, and to the desensitization expressed by these neurons.Key words: mesencephalic trigeminal neurons, glutamate, kainate, AMPA, oscillations, desensitization.

scholarly journals Electrophysiological aftereffects of high-frequency transcranial random noise stimulation (hf-tRNS): an EEG investigation

2021 ◽  
Author(s):  
Filippo Ghin ◽  
Louise O’Hare ◽  
Andrea Pavan
Keyword(s):  
High Frequency ◽  
Discrimination Task ◽  
Temporal Dynamics ◽  
Random Noise ◽  
Decomposition Analysis ◽  
Oscillatory Activity ◽  
Motion Direction ◽  
Time Frequency ◽  
Direction Discrimination ◽  
Transcranial Random Noise Stimulation

AbstractThere is evidence that high-frequency transcranial random noise stimulation (hf-tRNS) is effective in improving behavioural performance in several visual tasks. However, so far there has been limited research into the spatial and temporal characteristics of hf-tRNS-induced facilitatory effects. In the present study, electroencephalogram (EEG) was used to investigate the spatial and temporal dynamics of cortical activity modulated by offline hf-tRNS on performance on a motion direction discrimination task. We used EEG to measure the amplitude of motion-related VEPs over the parieto-occipital cortex, as well as oscillatory power spectral density (PSD) at rest. A time–frequency decomposition analysis was also performed to investigate the shift in event-related spectral perturbation (ERSP) in response to the motion stimuli between the pre- and post-stimulation period. The results showed that the accuracy of the motion direction discrimination task was not modulated by offline hf-tRNS. Although the motion task was able to elicit motion-dependent VEP components (P1, N2, and P2), none of them showed any significant change between pre- and post-stimulation. We also found a time-dependent increase of the PSD in alpha and beta bands regardless of the stimulation protocol. Finally, time–frequency analysis showed a modulation of ERSP power in the hf-tRNS condition for gamma activity when compared to pre-stimulation periods and Sham stimulation. Overall, these results show that offline hf-tRNS may induce moderate aftereffects in brain oscillatory activity.

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