Reoperative surgery in calves with a total artificial heart

1980 ◽  
Vol 3 (1) ◽  
pp. 24-29
Author(s):  
H. Fukumasu ◽  
D.B. Olsen ◽  
J.H. Lawson ◽  
A. Mochizuki ◽  
N. Daitoh ◽  
...  
Keyword(s):  
Artificial Heart ◽  
Surgical Techniques ◽  
Total Artificial Heart ◽  
Reoperative Surgery ◽  
Left Thoracotomy ◽  
Right Thoracotomy ◽  
The Right

Two surgical techniques have been developed in our laboratory to deal with identifiable problems in long-term artificial heart experiments. A right thoracotomy is used to deal with problems such as extensive bleeding, which occur in the immediate postoperative stage of the experiment, while a left thoracotomy is used in cases in Which the original implantation is preceded by more than one week, since extensive adhesions complicate the right thoracotomy at that stage. Pulmonary problems have been eliminated as a primary cause of difficulties after reoperation, but infection remains a serious problem.

Continuous-flow total artificial heart port-to-port connection technique using dedicated de-airing sleeve

Perfusion ◽  
2020 ◽  
Vol 35 (8) ◽  
pp. 861-864
Author(s):  
Jamshid H Karimov ◽  
Shengqiang Gao ◽  
Kiyotaka Fukamachi ◽  
Patrick Grady
Keyword(s):  
Continuous Flow ◽  
Artificial Heart ◽  
Surgical Techniques ◽  
Total Artificial Heart ◽  
Circulatory Support ◽  
Term Survival ◽  
Support Device ◽  
Mechanical Circulatory Support Device

Preventing the introduction of air while a mechanical circulatory support device is being implanted is critical for successful outcomes. A substantial amount of air may be introduced into the circulation during the pump-to-outflow and/or pump-to-inflow port connection, which can be detrimental to optimal pump function and long-term survival. We have developed a novel connecting sleeve that enables an airless connection of the continuous-flow total artificial heart to the conduits. Herein, we describe the device design and surgical techniques evaluated in vivo.

The Total Artificial Heart

1991 ◽  
Vol 2 (3) ◽  
pp. 587-597
Author(s):  
Lawrence E. Barker
Keyword(s):  
Artificial Heart ◽  
Total Artificial Heart ◽  
Thromboembolic Events ◽  
Bridge To Transplant ◽  
University Of Utah ◽  
Cardiac Assistance ◽  
Permanent Implants ◽  
Mechanical Devices ◽  
The University

In the early 1800s, an awareness of potential ventricular failure stimulated interest in artificial heart replacement. In 1937 the first total artificial heart (TAH) was implanted into the chest of a dog by Russian physicians. The primary driving force for mechanical cardiac assistance developed from the necessity for circulatory assistance in order to perform corrective cardiac surgery. In 1953 the first successful closure of an atrial septal defect using extracorporeal circulation was performed. During the following decade the concept of using mechanical devices to assist the failing heart was aggressively pursued. This culminated in the first implant of a TAH in a human in 1969 as a bridge to transplant. Clinical implant of the TAH as a permanent device was performed in 1982 by researchers at the University of Utah. This patient lived for 112 days. Three successive permanent implants were performed in Louisville, Kentucky, with one patient surviving for 620 days. All of these permanent TAH patients suffered from device-related complications including bleeding, infection, and thromboembolic events. It became apparent that the present configuration of the TAH with its external drive lines and large air console was not ideal for long-term support. In 1985 the first implant of the Symbion J-7-100 TAH (Jarvik-7) as a bridge to transplant was performed. This patient was supported by the device for 9 days and was successfully transplanted and discharged home. Since 1985 more than 170 patients have been bridged using the Symbion J-7 TAH with more than 70% of these patients being successfully transplanted. The incidence of thromboembolic events has dramatically reduced with better understanding of anticoagulation requirements. Infection continues to be the greatest potential complication with these patients. In spite of this, the pneumatic TAH has proved to be an adequate bridge to transplant device

Baylor Multi-Purpose One-Piece Total Artificial Heart (TAH) System for Short-Term to Long-Term Use

1993 ◽  
pp. 153-160 ◽  
Author(s):  
Motomi Shiono ◽  
Setsuo Takatani ◽  
Tatsuya Sasaki ◽  
Naoki Minato ◽  
Yukihiko Orime ◽  
...  
Keyword(s):  
Artificial Heart ◽  
Total Artificial Heart ◽  
Short Term

The Applicability of Experimental Experience with the Total Artificial Heart to its Clinical Use

1992 ◽  
Vol 15 (5) ◽  
pp. 307-311 ◽  
Author(s):  
J. Vašků ◽  
P. Urbánek ◽  
M. Dostál ◽  
Jan Vašků
Keyword(s):  
Clinical Application ◽  
Artificial Heart ◽  
Venous Pressure ◽  
Early Period ◽  
Total Artificial Heart ◽  
Blood Coagulation Disorders ◽  
Clinical Use ◽  
Long Term Experiments ◽  
Long Term Experiment

Long-term experiments with the total artificial heart (TAH) are a source of valuable knowledge for later clinical application. Our observations result from 66 long-term experiments on calves and one goat ranging from 30 to 314 days, which have shown the main possible complications in the early period (one month) and later in the experiment. Problems until the second month of pumping concern the clinical pendant of the TAH as a bridge for transplantation, i.e. surgical problems, blood coagulation disorders, infection etc. Later problems are high venous pressure or arterial hypertension, infection with septic thromboembolization, mineralization of the driving diaphragm, etc., and are more closely comparable to the conditions of permanent clinical use of the TAH. Faultless surgery, device function and the regimen of pumping are essential factors in every long-term experiment, just as in clinical application. Infection is a threat throughout any experiment, as in clinical cases. The TNS-BRNO-VII/clin/80 TAH has been implanted in six patients.

Histopathology Image Analysis in Two Long-Term Animal Experiments with Helical Flow Total Artificial Heart

2016 ◽  
Vol 40 (12) ◽  
pp. 1137-1145 ◽  
Author(s):  
Jiri Wotke ◽  
Pavel Homolka ◽  
Jaromír Vasku ◽  
Petr Dobsak ◽  
Petra Palanova ◽  
...  
Keyword(s):  
Image Analysis ◽  
Artificial Heart ◽  
Animal Experiments ◽  
Helical Flow ◽  
Total Artificial Heart ◽  
Histopathology Image Analysis

In Vivo Long-Term Evaluation of the Utah Electrohydraulic Total Artificial Heart

ASAIO Journal ◽  
1993 ◽  
Vol 39 (3) ◽  
pp. M373-M380 ◽  
Author(s):  
Eisuke Tatsumi ◽  
Pratap S. Khanwilkar ◽  
John R. Rowles ◽  
Bang Y. Chiang ◽  
Gregory L. Burns ◽  
...  
Keyword(s):  
Artificial Heart ◽  
Total Artificial Heart ◽  
Term Evaluation

IN VIVO AND CLINICAL STUDY OF PHOENIX-7 TOTAL ARTIFICIAL HEART

2001 ◽  
Vol 13 (03) ◽  
pp. 133-139
Author(s):  
CHEUNG-HWA HSU
Keyword(s):  
Blood Pressure ◽  
Artificial Heart ◽  
Cell Aggregation ◽  
Blood Chemistry ◽  
Multiple Organ ◽  
Total Artificial Heart ◽  
Red Blood Cell Aggregation ◽  
The Right ◽  
The Phoenix

This paper concerned with results of implantation of the Phoenix-7 total artificial heart (TAH) in the growing calves. Experimental study had been conducted 41 times in 41 calves. All the calves could breathe, stand, eat and void by themselves in two hours after operation. The causes of death essentially included respiratory failure, sepsis, hemorrhage shock, thrombo-embolism, and multiple organ failure. Autopsy was performed in all deaths. The phoenix hearts were opened and examined. Blood morphology and blood chemistry were welt analyzed. Deformation of the red blood cells was found in most of the cases. Cell destruction, however, was not obvious. Besides, there was no evidence of red blood cell aggregation. Initial clinical experience was undertaken for a 46-year-old male who was in cardiogenic shock. The patient was indwelled with intra-aortic balloon counter-pulsation (IABP) and supported by extra-corporeal membrane oxygenator (ECMO) before the implantation. With IABP and ECMO, the patient's blood pressure was maintained at 90/60mmHg, but oliguria persisted with the complication of hemolysis. The patient was then implanted with the Phoenix-7 TAH and the condition was improved tremendously. With the TAH, the patient's blood pressure was maintained at 90∼100mHg / 40∼50mmHg. Cardiac output was adequately maintained at 4.2~5.8 Llmin by an operating model on modifying the parameters of driving air pressure for both the right and left hearts, heart rate and systolic ratio. The patient had been on the device for 15 days until a successful simultaneous orthotopic heart and heterotopic kidney transplantation from a suitable donor was undertaken.

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