Sedation and Analgesia for Children in the Pediatric Intensive Care Unit
Several situations arise in the Pediatric Intensive Care Unit (PICU) patient which may require the pharmacologic control of pain and anxiety. The author discusses the various pharmacologic agents available for sedation and analgesia including the inhalational anesthetic agents, nitrous oxide, benzodiasepines, opioids, ketamine, propofol, and the barbiturates. While intravenous administration is generally chosen for the PICU patient, certain situations may arise which preclude this route. The available information concerning alternative routes of delivery for the various agents including subcutaneous and transmucosal administration is presented. The role of various regional anesthetic techniques to control pain in the PICU patient are reviewed.