Estimation of the treatment effect under an incomplete block crossover design in binary data – A conditional likelihood approach

2015 ◽  
Vol 26 (5) ◽  
pp. 2197-2209 ◽  
Author(s):  
Kung-Jong Lui
Keyword(s):  
Treatment Effect ◽  
Binary Data ◽  
Crossover Design ◽  
Conditional Likelihood ◽  
Incomplete Block ◽  
Likelihood Approach

Exact tests in binary data under an incomplete block crossover design

2016 ◽  
Vol 27 (2) ◽  
pp. 579-592 ◽  
Author(s):  
Kung-Jong Lui ◽  
Kuang-Chao Chang
Keyword(s):  
Binary Data ◽  
Logistic Regression Model ◽  
Crossover Trial ◽  
Test Procedure ◽  
Crossover Design ◽  
Incomplete Block ◽  
Primary Dysmenorrhea ◽  
Test Procedures ◽  
Exact Test ◽  
High Doses

To improve the power of a parallel groups design and reduce the time length of a crossover trial, we may consider an incomplete block crossover design. Under a distribution-free random effects logistic regression model, we derive an exact test and a Mantel-Haenszel Type of summary test procedure for testing non-equality in binary data when comparing three treatments. We employ Monte Carlo simulation to evaluate the performance of these test procedures. We find that both test procedures developed here can perform well in a variety of situations. We use the data taken as a part of the crossover trial comparing the low and high doses of an analgesic with a placebo for the relief of pain in primary dysmenorrhea to illustrate the use of the proposed test procedures.

Analysis of multiple exposures in the case-crossover design via sparse conditional likelihood

2012 ◽  
Vol 31 (21) ◽  
pp. 2290-2302 ◽  
Author(s):  
Marta Avalos ◽  
Yves Grandvalet ◽  
Nuria Duran Adroher ◽  
Ludivine Orriols ◽  
Emmanuel Lagarde
Keyword(s):  
Crossover Design ◽  
Conditional Likelihood ◽  
Multiple Exposures ◽  
Case Crossover

scholarly journals A polytomous conditional likelihood approach for combining matched and unmatched case-control studies

2010 ◽  
Vol 29 (9) ◽  
pp. 1004-1013
Author(s):  
Mulugeta Gebregziabher ◽  
Paulo Guimaraes ◽  
Wendy Cozen ◽  
David V. Conti
Keyword(s):  
Case Control ◽  
Conditional Likelihood ◽  
Case Control Studies ◽  
Likelihood Approach

Behavioral Testing of Antidepressant Compounds: An Analysis of Crossover Design for Correlated Binary Data

2005 ◽  
Vol 47 (3) ◽  
pp. 286-298
Author(s):  
Ziv Shkedy ◽  
Veerle Vandersmissen ◽  
Geert Molenberghs ◽  
Hansfried Van Craenendonck ◽  
Nancy Aerts ◽  
...  
Keyword(s):  
Binary Data ◽  
Crossover Design ◽  
Behavioral Testing ◽  
Correlated Binary Data
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