Carcinoma Showing Thymus-Like Differentiation (CASTLE) Arising in the Sublingual Gland

2020 ◽  
pp. 106689692094160
Author(s):  
Laura Ardighieri ◽  
Michele Tomasoni ◽  
Simonetta Battocchio ◽  
Fabio Facchetti ◽  
Roberto Maroldi ◽  
...  

Carcinoma showing thymic-like differentiation (CASTLE) is a rare tumor most commonly occurring in the thyroid and soft tissues of the neck. We report the first case of CASTLE occurring in the sublingual gland. The patient, a 35-year-old healthy man, presented with a submucosal lesion located in the anterior right floor of the oral cavity and an ipsilateral neck mass. The lesion had been previously investigated by neck computed tomography and ultrasound-guided fine needle aspiration cytology and diagnosed as metastatic squamous cell carcinoma. After oral cavity magnetic resonance imaging, positron emission tomography, and a non-diriment, fine needle aspiration cytology of the sublingual mass, the patient was treated as affected by a sublingual gland malignancy with removal of primary tumor and neck dissection. Morphological and immunohistochemical findings were diagnostic for primary sublingual gland CASTLE. The patient received adjuvant radiotherapy and is free of disease 2 years after treatment. We describe the pathological features of the lesion and discuss the possible differential diagnoses.

2020 ◽  
Vol 134 (9) ◽  
pp. 830-837
Author(s):  
P Touska ◽  
G Oikonomou ◽  
R Ngu ◽  
A Chandra ◽  
A Malhotra ◽  
...  

AbstractObjectiveThe global coronavirus disease 2019 (COVID-19) pandemic has necessitated rapid alterations to diagnostic pathways for head and neck cancer patients that aim to reduce risk to patients (exposure to the hospital environment) and staff (aerosol-generating procedures). Transoral fine needle aspiration cytology offers a low-risk means of rapidly diagnosing patients with oral cavity or oropharyngeal lesions. The technique was utilised in selected patients at our institution during the pandemic. The outcomes are considered in this study.MethodDiagnostic outcomes were retrospectively evaluated for a series of patients undergoing transoral fine needle aspiration cytology of oral cavity and oropharyngeal lesions during the COVID-19 pandemic.ResultsFive patients underwent transoral fine needle aspiration cytology, yielding lesional material in 100 per cent, with cell blocks providing additional information. In one case, excision biopsy of a lymphoproliferative lesion was required for final diagnosis.ConclusionTransoral fine needle aspiration cytology can provide rapid diagnosis in patients with oral cavity and oropharyngeal lesions. Whilst limitations exist (including tolerability and lesion location), the technique offers significant advantages pertinent to the COVID-19 era, and could be employed in the future to obviate diagnostic surgery in selected patients.


1999 ◽  
Vol 43 (3) ◽  
pp. 457-463 ◽  
Author(s):  
Hitoshi Hara ◽  
Toshio Oyama ◽  
Kimie Omori ◽  
Tsuneyoshi Misawa ◽  
Hachiro Kasai ◽  
...  

Rare Tumors ◽  
2012 ◽  
Vol 4 (4) ◽  
pp. 172-174 ◽  
Author(s):  
Rehab M. Samaka ◽  
Mona A. Kandil

Parachordoma is an extremely rare soft tissue tumor of unknown lineage. Parachordoma develops most often on the extremities. Only 2 cases have been reported as pelvic parachordoma. A 46-year old Egyptian woman with a huge painful pelvic mass was found to have a parachordoma with ectopic pelvic right kidney. There is only one report in the literature of fine needle aspiration cytology in this setting. The microscopic picture of parachordoma is not new to pathologists but the gross picture of this rare tumor has not previously been published; not even in the World Health Organization classification of soft tissues tumors. Diagnosis was confirmed by immunohistochemistry. The patient is in good clinical condition without any evidence of recurrence or metastasis after 84 months of follow up.


2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Neha Meena ◽  
Pooja Arora

<p class="Body"><span lang="EN-US">Giant cell tumour of the tendon sheath (GCTTS) is a slow-growing, usually painless benign lesion of soft tissues<span style="font-size: 8.33333px;">.</span> We report the case of a 38-year-old male with a painless, slowly enlarging swelling on right thumb in order to highlight the role of fine-needle aspiration cytology (FNAC) in diagnosing GCTTS.</span></p>


Cytopathology ◽  
2014 ◽  
Vol 25 (4) ◽  
pp. 241-249 ◽  
Author(s):  
I. Cozzolino ◽  
E. Vigliar ◽  
P. Todaro ◽  
A. L. Peluso ◽  
M. Picardi ◽  
...  

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