Synchronization Of Autonomic Control Loops Of Blood Circulation In Patients With COVID-19

This study aims to investigate the strength of synchronization between the autonomic control loops of the cardiovascular system (CVS) in patients with COronaVIrus Disease 2019 (COVID-19). Methods — We calculated the total percent of phase synchronization index (S index) between the loops of autonomic control of heart rate and vascular tone in two sample groups: healthy individuals and COVID-19 patients. Results — The group-average value of the S index in COVID-19 patients is lower comparing to healthy individuals, the Mann-Whitney U-test confirmed that the differences are statistically significant. Conclusion — Obtained results suggest that the decreased value of the S index reflects the presence of a viral disease, and the S index is a promising basis for non-invasive screening diagnostics of viral diseases, particularly of COVID-19.

Job Satisfaction Among Pharmacists

Job satisfaction among pharmacists affects the quality of pharmaceutical care and patient health. Our study targeted the evaluation of job and salary satisfaction levels in pharmacists and the factors affecting these levels. Methods — We conducted the survey of 407 pharmacists working at community pharmacies in Saratov Oblast (Russia). Results — The proportions of pharmacists satisfied with their jobs and their salaries were 77.1±0.4% and 52.8±0.4%, respectively. We discovered that salary satisfaction was influenced primarily by the household composition (p=0.004) and professional commitment (p<0.001). Pharmacists who were more satisfied with their jobs belonged to the age category ‘up to 44 years’ (p=0.002). They were less likely to change their employment (p<0.001) and more likely to experience positive emotions when performing their professional activities (p<0.001). Also, they were more satisfied with their salaries (p<0.001), committed to their profession (p<0.001), and more likely to perceive the social importance of their profession (p<0.001). Conclusion — Our findings suggested that formal traits of pharmaceutical professionals had a smaller impact on their job satisfaction, while the greatest impact was caused by the personal characteristics (perception of the social importance of their profession, professional commitment), salary satisfaction, age and frequency of changing jobs.

Exposure To Cytotoxic Drugs Threatens The Health Of Staff In Oncology Wards

Background — Cancer is one of the leading causes of death worldwide. Using cytotoxic drugs for cancer treatment is increased. The hazardous effects of occupational exposure to cytotoxic drugs are challenging. Objective — This study aimed to compare the frequency of adverse effects and using personal protective equipment (PPE) between the staff of oncology wards and other hospital wards staff in Iran. Methods — A cross-sectional study with a control group was conducted on female staff members in educational hospitals, selected through convenience sampling. A data collection form was designed for this study. It includes demographic data, acute complications (allergic and neurologic reactions), chronic complications (infertility, menstrual disorders, malignancy, and congenital malformations), and use of PPE. Data analysis was performed using SPSS software through Chi-square and Mann-Whitney tests. Results — The frequencies of chronic complications were not statistically different between the two groups. The frequency of itching (P=0.001), hair loss (P=0.003), itchy eyes (P=0.001), watery eyes (P=0.001), runny nose (P=0.003), headache (P=0.001), vertigo (P=0.007), and nausea (P=0.008) were significantly higher in oncology wards nurses. Among different PPE, only the frequency of using the mask (P= 0.001), and glasses (P=0.027) were significantly higher in the staff of oncology wards. Conclusion — Despite the frequency of acute complications of exposure to cytotoxic drugs, oncology staff does not fully adhere to the standard precautions. Providing effective training and emphasis on implementing accreditation laws can improve the existing situation.

Problematic Cellular Phone Use: A Factor Analysis

Background — Increasing access to smartphones has led some researches to focus in this regard. Objective — the current study aimed to determine psychometric properties of the Persian version of Problematic Cellular Phone Use Questionnaire (PCPU-Q) among medical student at Kerman University of Medical Sciences. Material and Methods — A cross-sectional study carried out on 351 medical students. Data collected using a questionnaire including demographic data and the Persian versions of PCPU-Q. The higher score indicates a greater problem. Data analyzed by SPSS 20 and Lisrel 8.8. Cronbach’s alpha and intraclass correlation coefficient (ICC) and exploratory/confirmatory factor analysis used for determining the reliability and construct validity of the questionnaire, respectively. Results — One hundred and seventy-two (49.0%) of the students had a problematic CPU. Cronbach’s alpha and ICC were 0.8 and 0.91, respectively. The model had acceptable goodness of fit indices in confirmatory factor analysis. Conclusion — The Persian version of PCPU-Q had good psychometric properties and can be useful for screening of problematic CPU among Iranian youth.

Clinical Manifestations, Histopathological Changes And Quality Of Life In Patients With Advanced Knee Osteoarthritis Caused By Age, Trauma, Obesity And Their Combination

Objective — to reveal and analyze clinical characteristics, knee joint histopathology, and quality of life in patients at late stages of knee osteoarthritis (OA) triggered by age, trauma, metabolic syndrome, or their combination. Material and methods — We studied 120 subjects with knee OA (sensu Altman R.D., 1991) of Kellgren-Lawrence Grades 3-4. They were distributed among 4 groups (30 participants in each) based on the presence of age-related, post-traumatic, metabolic, or combined phenotypes. Clinical examination of patients with pain and their functional status evaluation (via Visual Analogue Scale, WOMAC, Lequesne index), quality of life assessment (MOS SF-36 questionnaire), along with histopathological study of medial tibial plateau cartilage and synovial membrane, were caried out, followed by statistical data processing. Results — Age-related OA phenotype was characterized by the latest clinical onset [59.5 (54-68) years of age] with the largest average patient age [72.5 (63-77) years], moderate to severe pain and knee dysfunction [total WOMAC score of 160 (127-190) points and Lequesne index of 20 (8-21) points], severe degenerative cartilage lesions [8.5 (6-10) points sensu Mankin] with high-grade synovitis [5 (3-8) points sensu Krenn]. Post-traumatic OA phenotype was distinguished by the lowest pain, stiffness and knee functional limitations [total WOMAC score of 129 (100-166), Lequesne index of 15 (14-19)], the highest quality of life in patients [physical component summary of 34.1 (30.5-36.1) points, mental component summary of 40.4 (32.9-43.8) points] against the background of local severe cartilage lesions [8 (6-8) sensu Mankin] with reparative pattern and synovial fibrosis. For metabolic OA phenotype, the typical traits included female-biased sex ratio (87%), high prevalence of clinical synovitis (77%), severe pain and functional knee disorders [total WOMAC score of 188 (162-207) points, Lequesne index of 20 (19-23) points], the worst quality of life [physical component summary of 28.0 (24.3-31.9) points, mental component summary of 30.9 (26.9-35.9) points], vascular invasion of cartilage, and high-grade synovitis [4 (3-5) points sensu Krenn]. Combined OA phenotype was characterized by variable clinical and histopathological features. Conclusion — Comprehensive comparative clinical and morphological analysis of late-stage knee OA of various origin was completed, and age-related, post-traumatic, metabolic and combined OA phenotypes were studied. The methodological basis for differential approach to treating different categories of OA patients was developed.

Evaluating Occupational Morbidity Among Energy Enterprise Employees In Industrial Region Of Kazakhstan

Our research project was aimed at studying the effects of an electromagnetic field of industrial frequency (EMF-IF) on employees of an energy company in Kazakhstan. Material and Methods — The object of our study was the health status of electricians (morbidity with temporary disability – MTD), engaged in the maintenance of power lines, relay protection systems and substations (220 and 500 kV) at an energy enterprise in Kazakhstan. The interrelation and dependence of the intensive MTD indicators on the hygienic factors at the workplace were determined, and the risks were calculated from the obtained data. Results — Unfavorable workplace conditions caused an increase in disorders of the musculoskeletal system (up to 77%), blood circulation (up to 65%), nervous system (up to 52%), skin diseases (up to 46.4%), as well as the manifold rise of the likelihood of neoplasm growth and respiratory diseases. For electricians, the relationships between the nervous system disorders (r=0.792), the circulatory system diseases (r=0.573), the musculoskeletal system ailments (r=0.672) and the EMF-IF parameters were discovered. At the same time, the dependence of the incidence rates of various diseases in workers on EMF, as well as moderate to high computed relative risks, implied the occupational genesis of worklace ailments: for nervous system – R2=0.628, cardiovascular system – R2=0.709, skin – R2=0.729, and musculoskeletal system – R2=0.413. Conclusion — As preventive measures for electricians, we recommended to wear individual exposure meters, to limit work in contact with EMF, to include an oncologist in the medical commission, and for trainees, to screen for oxidative stress proteins and chaperone proteins to exclude a predisposition to oncogenesis.

Experimental Modeling Of Hypothyroidism: Principles, Methods, Several Advanced Research Directions In Cardiology

Hypothyroidism is one of the most common pathological conditions in modern clinical practice. Due to the fact that the targets of thyroid hormones are virtually all organs and tissues, the morphological and clinical manifestations arising with a deficiency of thyroid hormones are quite diverse. Experimental models of hypothyroidism in laboratory animals are widely used for preclinical study of the fundamental pathophysiological mechanisms underlying hypothyroidism, as well as for assessing the effectiveness of treatment-and-prophylactic effects. Currently, several groups of effective models of hypothyroidism have been developed: dietary, surgical, medicamentous, genetic, radioactive and immunological. Each of the specified models is based on different principles, has advantages and disadvantages, and can be used depending on the goals and objectives of the experiment. In this review, we will consistently consider hypothyroidism modeling methods and indicate some promising areas of their use in cardiology.

Contemporary Features Of Predicting The Development Of Luteal Insufficiency And Related Gestational Disorders

The goal of our study was a comprehensive assessment of obstetric, gynecological, somatic and genetic factors, contributing to high risk of insufficient luteal phase (ILP) and relating gestational disorders to the latter in relevant patients for further optimization of therapeutic and preventive measures. Material and Methods — A cohort study with a mixed cohort was carried out. The clinical material of the retrospective study was presented based on the results of analyzing 300 cases of patients with verified diagnoses of the threat of spontaneous abortion, miscarriage, and complete spontaneous abortion, who were hospitalized in the period of 2018-2020. As part of a prospective study, we analyzed 66 blood samples of women treated at the State Budgetary Healthcare Institution Simferopol Clinical Maternity Hospital No.2 in Crimea in 2020. The polymerase chain reaction method in real time mode, with the use of the developed kits, was used for CYP3A5 6986A> G polymorphism. Results — A comprehensive assessment of obstetric, gynecological, somatic and genetic factors allowed identifying the most informative prognostic markers for the risk of developing luteal phase insufficiency and related gestational disorders, including irregular menstrual cycle, cases of drug-induced abortion, preceding specific infectious diseases (chlamydia, Ureaplasma urealyticum infection), gynecological pathology (polycystic ovary syndrome), surgical interventions performed for gynecological pathology (ovarian resection and ovariectomy), as well as single nucleotide polymorphism rs776746 in the CYP3A5 gene. Conclusion — The identified prognostic criteria make it possible to identify a group of patients with a high risk of miscarriage even before the conception; such patients need more careful and systematic medical monitoring for the timely diagnosis of possible pregnancy complications. Early diagnosing of potential issues would allow clinicians to take preventive measures, along with initiating timely treatment. As a result, the percentage of reproductive losses would go down.

Knowledge And Judgments About Standard Precautions For Nosocomial Infection: Comparative Analysis Of Medical Vs. Non-Medical Students

Background — Nosocomial infection (NI) is among the most common and serious challenges in a healthcare system. Health workers and medical students play an important role in prevention of NI. Despite advances in the field of medicine in Kazakhstan, low detection rate of NIs remains unchanged, which could be due to a lack of awareness of the standard precautions for infection control among medical students and health workers. This study is aimed at examining knowledge and judgments on NIs among medical and non-medical students. Material and Methods — We conducted a cross-sectional paper-based survey to examine the knowledge and judgments about the standard precautions for NI among medical and non-medical students. Data collection took place between September 21 and December 20, 2017. Results — The study enrolled 2,817 students. The mean overall score (±SD) was 2.045±1.29. Medical students had a better mean overall score (2.113) than non-medical students (1.785; p<0.001). Awareness of the standard preventive measures was increasing with a year of study, but still just one-third of year 5 medical students were aware of standard prevention (36.3% vs. 17.4% for non-medical students; p<0.001). Conclusion — The overall score of our survey indicated inadequate knowledge and awareness of the guidelines on infection prevention and control among both medical and non-medical students. In order to improve patient safety and welfare, the courses on infection control should be introduced into the curricular of medical universities in Kazakhstan.

Features Of Anxiety And Attention In Elementary School Students Of The Russian North

A child’s body in the contemporary educational process with innovative programs and electronic devices, along with insufficient motor activity, against the background of low reserve capacity in the North, experiences the psychoemotional stress. The objective of our study was to investigate the anxiety and attention in elementary school students in the northern cities of Magadan Oblast. The study was conducted on elementary school students (9.9±0.05 years of age) in the regional center of Magadan and the remote town of Magadan Oblast, Susuman. Group I consisted of 108 Magadan school students, whereas Group II included 82 Susuman school students. Methods — we used the methodology of multidimensional assessment of childhood anxiety (MACA). To investigate the function of attention, we used the method of proofreading modified by V.N. Amatuni. Results — the number of anxious children was 42% in Magadan and 26% in Susuman. Magadan children were significantly more anxious than their Susuman peers on five of ten scales: in connection with the evaluation by others (M±SE: p=0.013; Me [Q1; Q3]: p<0.05); in their relationships with teachers (p=0.003; p<0.01); in terms of their learning success (p=0.016; p<0.05); in situations of knowledge testing (p=0.022; p<0.05); and they also exhibited an increase in their autonomic reactivity associated with anxiety (p=0.040; p<0.05). It was revealed as well that the neurodynamic characteristics of attention were better in the group of Susuman children. Conclusion — It can be assumed that elementary school students in small remote towns are less at risk of school maladjustment and are more efficient than their peers living in larger cities, where anxiety is higher, which complicates the learning process.