Churg-Strauss Syndrome Development during Asthma Therapy with Leukotriene Receptor Antagonists: Just a Coincidental Association?

2004 ◽  
Vol 2 (3) ◽  
pp. 133-139
Author(s):  
D. De Nardo ◽  
G. De Sanctis ◽  
L. Biancone ◽  
J. Khalil ◽  
B. Kroegler ◽  
...  
Keyword(s):  
Asthma Therapy ◽  
Receptor Antagonists ◽  
Churg Strauss Syndrome ◽  
Leukotriene Receptor Antagonists ◽  
Strauss Syndrome ◽  
Leukotriene Receptor ◽  
Churg Strauss

Churg-Strauss syndrome and the leukotriene receptor antagonist pranlukast

2004 ◽  
Vol 24 (6) ◽  
pp. 661-662 ◽  
Author(s):  
Junsuke Shimbo ◽  
Osamu Onodera ◽  
Keiko Tanaka ◽  
Shoji Tsuji
Keyword(s):  
Receptor Antagonist ◽  
Leukotriene Receptor Antagonist ◽  
Churg Strauss Syndrome ◽  
Strauss Syndrome ◽  
Leukotriene Receptor ◽  
Churg Strauss

scholarly journals A Case of Montelukast-Induced Churg-Strauss Syndrome Associated with Liver Dysfunction

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Keiji Matsui ◽  
Kosuke Nishijima
Keyword(s):  
Liver Dysfunction ◽  
Carnitine Deficiency ◽  
Acid Oxidation ◽  
Fatty Change ◽  
Churg Strauss Syndrome ◽  
History Of ◽  
Strauss Syndrome ◽  
Leukotriene Receptor ◽  
The Relationship ◽  
Churg Strauss

A 64-year-old woman was admitted to hospital due to protracted diarrhea and liver dysfunction. The patient was diagnosed as Churg-Strauss syndrome (CSS) due to asthma, paranasal sinusitis, hypereosinophilia, and polyneuropathy. There was a history of taking montelukast, a leukotriene receptor antagonist (LTRA), which is thought to have some relationship with CSS. The liver biopsy specimen showed eosinophilic infiltration and centrolobular fatty change. In this paper, we review the relationship between LTRA and CSS. Several lines of evidence suggest that leukotriene plays an important role in maintaining neural tissues. We also review the potential relationship between centrolobular fatty change and pivoxil-containing antibiotics, which was prescribed for sinusitis before admission. Carnitine deficiency induced by pivoxil-containing agents may cause impaired fatty acid oxidation in mitochondria.

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