churg strauss syndrome
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2021 ◽  
Vol 429 ◽  
pp. 118827
Author(s):  
Francesco Germano ◽  
Tiziano Tamburini ◽  
Elena Coco ◽  
Davide Brogi ◽  
Alessandro Russo ◽  
...  

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110483
Author(s):  
Aleksandra Kezić ◽  
Stojanka Ristić ◽  
Maja Životić ◽  
Jasmina Marković-Lipkovski ◽  
Svetlana Kovačević ◽  
...  

Churg–Strauss syndrome (CSS) is a granulomatous small-vessel vasculitis. Asthma is seen in the majority of patients with CSS, but atypical nonasthmatic forms of CSS are also being recognized. We herein describe a 67-year-old woman with a history of chronic pyelonephritis and drug allergy reactions who was admitted to our hospital because of worsening renal function preceded by fever, purpura, sinusitis, and a positive urine culture that confirmed a urinary infection. She was initially treated with pipemidic acid for 7 days, followed by clarithromycin for sinusitis. Laboratory tests on admission showed an absolute eosinophil count of 1750 cells/µL and serum creatinine concentration of 4.72 mg/dL. Urine and blood cultures showed no growth. Kidney biopsy revealed crescent formations with diffuse interstitial fibrosis and foci of eosinophil infiltration. An atypical form of CSS was diagnosed based on tissue eosinophilia, peripheral eosinophilia, and sinusitis. Intravenous methylprednisolone and cyclophosphamide pulse therapy together with hemodialysis treatment improved the patient’s clinical condition but did not resolve the kidney damage. The onset of an atypical form of CSS in our patient manifested as symptoms and signs mimicking those of chronic pyelonephritis and drug allergy reactions. The patient’s chronic kidney disease finally progressed to dialysis dependence.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Maria Clara Zanon Zotin ◽  
Barbara S.A. Cunha ◽  
Fernando Chahud ◽  
Antonio Augusto Velasco e Cruz,

2021 ◽  
Vol 6 (3) ◽  
pp. 63-65
Author(s):  
Uday Mahajan ◽  
Deepika Kapil

Churg-Strauss syndrome is a disorder of hypereosinophilia and systemic vasculitis in subjects with asthma and allergic rhinitis. Patient was admitted with chief complaints of cough without expectoration for a duration of three weeks without accompanying fever. X ray revealed pleural effusion ‘right side’. Exudative pleural fluid with eosinophil predominance and peripheral eosinophilia. The patient was further investigated. No history suggestive of any drug use. stool routine microscopy show no parasites. ANA investigated found to be positive in 1: 80 titre in homogenous pattern. Patient was then found to be P-ANCA positive by immunofluorescence microscopy. Patient was successfully treated with oral prednisolone 40 mg for three months and subsequently improved with disappearance of symptoms. Keywords: Churg-Strauss syndrome, Pleural effusion, hypereosinophilia.


Author(s):  
Pistacchi Michele ◽  
Gioulis Manuela ◽  
Ferrari Sergio ◽  
Cavallaro Tiziana ◽  
Marsala Sandro Zambito

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