scholarly journals Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146

2017 ◽  
Vol 12 (1) ◽  
pp. 1934578X1701200
Author(s):  
Nils Böhringer ◽  
Michael Gütschow ◽  
Gabriele M. König ◽  
Till F. Schäberle
Keyword(s):  
Polyketide Synthase ◽  
Streptomyces Coelicolor ◽  
Cathepsin L ◽  
Human Leukocyte ◽  
Structural Similarity ◽  
Protease Inhibition ◽  
Leukocyte Elastase ◽  
Type Iii Polyketide Synthase ◽  
Human Leukocyte Elastase ◽  
High Structural Similarity

Overexpression of a putative type III polyketide synthase (PKSIII) from the marine myxobacterium Enhygromyxa salina SWB007 in Streptomyces coelicolor M1146 led to the accumulation of a novel monoketopiperazine consisting of phenylalanine and isoleucine. This compound was named phileucin and shows high structural similarity to phevalin (aureusimine B). The protease inhibiting activity was tested against human cathepsin L, human leukocyte elastase, bovine trypsin and bovine chymotrypsin. In contrast to phevalin, no protease inhibition was observed.

Design, Synthesis, and Enzymatic Evaluation ofN1-Acyloxyalkyl- andN1-Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase

2005 ◽  
Vol 48 (15) ◽  
pp. 4861-4870 ◽  
Author(s):  
Rui Moreira ◽  
Ana Bela Santana ◽  
Jim Iley ◽  
João Neres ◽  
Kenneth T. Douglas ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Design Synthesis ◽  
Human Leukocyte Elastase

ChemInform Abstract: FR901451, a Novel Inhibitor of Human Leukocyte Elastase from Flexibacter sp. Part 2. Pharmacological Effect of FR901451.

ChemInform ◽  
2010 ◽  
Vol 26 (23) ◽  
pp. no-no
Author(s):  
T. FUJITA ◽  
Y. SHINGUH ◽  
A. YAMAZAKI ◽  
K. NAKAHARA ◽  
M. OKAMOTO ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Pharmacological Effect ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Heterocyclic inhibitors of human leukocyte elastase: 3-Hydroxypyridazopyrimidine, 3-hydroxypyridopyrimidine and 3-hydroxyquinazoline-2,4-1H,3H0dione derivatives

1993 ◽  
Vol 3 (6) ◽  
pp. 1163-1168 ◽  
Author(s):  
William C. Groutas ◽  
James C. Castrisos ◽  
Michael A. Stanga ◽  
Rong-ze Kuang ◽  
Radhika Venkataraman ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives

Biochemistry ◽  
1992 ◽  
Vol 31 (21) ◽  
pp. 4980-4986 ◽  
Author(s):  
W. B. Knight ◽  
A. L. Maycock ◽  
B. G. Green ◽  
B. M. Ashe ◽  
P. Gale ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Mechanism Of Inhibition ◽  
Human Leukocyte Elastase

Pulmonary Hemorrhage Induced by Intratracheal Administration of Human Leukocyte Elastase in Hamsters

1991 ◽  
Vol 624 (1) ◽  
pp. 331-333 ◽  
Author(s):  
ROBERT J. GORDON ◽  
EDWARD FERGUSON ◽  
RICHARD DUNLAP ◽  
CATHERINE FRANKE ◽  
PAUL J. SILVER
Keyword(s):  
Pulmonary Hemorrhage ◽  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Intratracheal Administration ◽  
Human Leukocyte Elastase
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