Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis

Specific Inhibitors

Mechanism-based inhibition of human leukocyte elastase and cathepsin G by susbtituted dihydrouracils

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ◽

10.1016/0925-4439(94)90087-6 ◽

1994 ◽

Vol 1227 (3) ◽

pp. 130-136 ◽

Cited By ~ 6

Author(s):

William C. Groutas ◽

Jeffrey B. Epp ◽

Radhika Venkataraman ◽

Jerald J. McClenaha ◽

Fusao Tagusagawa

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

New mechanism based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthalide

Journal of the American Chemical Society ◽

10.1021/ja00359a042 ◽

1983 ◽

Vol 105 (21) ◽

pp. 6518-6520 ◽

Cited By ~ 19

Author(s):

J. Wade Harper ◽

Keiji Hemmi ◽

James C. Powers

Keyword(s):

Serine Protease ◽

Protease Inhibitors ◽

Human Leukocyte ◽

Cathepsin G ◽

Serine Protease Inhibitors ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase

Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study

Bioorganic & Medicinal Chemistry ◽

10.1016/0968-0896(95)00006-3 ◽

1995 ◽

Vol 3 (2) ◽

pp. 125-128 ◽

Cited By ~ 28

Author(s):

William C. Groutas ◽

Radhika Venkataraman ◽

Lee S. Chong ◽

James E. Yoder ◽

Jeffrey B. Epp ◽

...

Keyword(s):

Proteolytic Enzymes ◽

Human Leukocyte ◽

Cathepsin G ◽

Activity Relationship ◽

Proteinase 3 ◽

Leukocyte Elastase ◽

Structure Activity ◽

Relationship Study ◽

Potential Inhibitors

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A.alpha., and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates

Biochemistry ◽

10.1021/bi00308a023 ◽

1984 ◽

Vol 23 (13) ◽

pp. 2995-3002 ◽

Cited By ~ 78

Author(s):

J. Wade Harper ◽

Robert R. Cook ◽

C. Justine Roberts ◽

Beth H. McLaughlin ◽

James C. Powers

Keyword(s):

Active Site ◽

Serine Proteases ◽

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Site Mapping ◽

Porcine Pancreatic Elastase ◽

And Staphylococcus Aureus

Kinetic Studies on the Interaction of Eglincwith Human Leukocyte Elastase and Cathepsin G

Biological Chemistry Hoppe-Seyler ◽

10.1515/bchm3.1987.368.1.299 ◽

1987 ◽

Vol 368 (1) ◽

pp. 299-308 ◽

Cited By ~ 40

Author(s):

Nancy J. BRAUN ◽

Judith L. BODMER ◽

G. Duke VIRCA ◽

Gabrielle METZ-VIRCA ◽

Reinhard MASCHLER ◽

...

Keyword(s):

Human Leukocyte ◽

Kinetic Studies ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A.alpha., and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones

Biochemistry ◽

10.1021/bi00329a006 ◽

1985 ◽

Vol 24 (8) ◽

pp. 1841-1848 ◽

Cited By ~ 17

Author(s):

Keiji Hemmi ◽

J. Wade Harper ◽

James C. Powers

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase

The Sulfate Groups of Chondroitin Sulfate- and Heparan Sulfate-containing Proteoglycans in Neutrophil Plasma Membranes Are Novel Binding Sites for Human Leukocyte Elastase and Cathepsin G

Journal of Biological Chemistry ◽

10.1074/jbc.m608346200 ◽

2007 ◽

Vol 282 (19) ◽

pp. 14645-14654 ◽

Cited By ~ 66

Author(s):

Edward J. Campbell ◽

Caroline A. Owen

Keyword(s):

Heparan Sulfate ◽

Chondroitin Sulfate ◽

Binding Sites ◽

Plasma Membranes ◽

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm00073a019 ◽

1993 ◽

Vol 36 (21) ◽

pp. 3178-3181 ◽

Cited By ~ 31

Author(s):

William C. Groutas ◽

Nadene Houser-Archield ◽

Lee S. Chong ◽

Radhika Venkataraman ◽

Jeffrey B. Epp ◽

...

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of .alpha.1-protease inhibitor (.alpha.1-antitrypsin)

Biochemistry ◽

10.1021/bi00558a013 ◽

1980 ◽

Vol 19 (17) ◽

pp. 3973-3978 ◽

Cited By ~ 81

Author(s):

Brian McRae ◽

Kiichiro Nakajima ◽

James Travis ◽

James C. Powers

Keyword(s):

Protease Inhibitor ◽

Human Leukocyte ◽

Cathepsin G ◽

Reactive Site ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase ◽

Alpha 1 Antitrypsin

Comparison of the Proteoglycanolytic Activities of Human Leukocyte Elastase and Human Cathepsin G in Vitro and in Vivo

Connective Tissue Research ◽

10.3109/03008209309032926 ◽

1993 ◽

Vol 30 (1) ◽

pp. 1-9 ◽

Cited By ~ 15

Author(s):

Joseph McDonnell ◽

Julie M. Lobner ◽

W. Blaine Knight ◽

Michael W. Lark ◽

Barbara Green ◽

...

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Human Cathepsin