Cancer Chemopreventive Activity of Xanthones from Calophyllum elatum

In our continuing search for compounds with antitumor-promoting activity, we screened eight xanthones isolated from Calophyllum elatum Bedd. (Guttiferae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Several compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Isogarciniaxanthone E (2) showed more potent activity than any of the other compounds tested. Furthermore, isogarciniaxanthone E (2) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

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Inhibitors of Skin-Tumor Promotion. XIII. Inhibitory Effects of Euglobals and Their Related Compounds on Epstein-Barr Virus Activation and on Two-Stage Carcinogenesis of Mouse Skin Tumors. (2).

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.18.288 ◽

1995 ◽

Vol 18 (2) ◽

pp. 288-294 ◽

Cited By ~ 8

Author(s):

Midori TAKASAKI ◽

Takao KONOSHIMA ◽

Mutsuo KOZUKA ◽

Koichi YONEYAMA ◽

Shigeo YOSHIDA ◽

...

Keyword(s):

Epstein Barr Virus ◽

Mouse Skin ◽

Tumor Promotion ◽

Skin Tumors ◽

Skin Tumor ◽

Inhibitory Effects ◽

Two Stage ◽

Barr Virus ◽

Epstein Barr ◽

Related Compounds

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Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein–Barr virus activation and mouse skin tumor promotion

Cancer Letters ◽

10.1016/s0304-3835(02)00336-1 ◽

2002 ◽

Vol 186 (1) ◽

pp. 37-41 ◽

Cited By ~ 11

Author(s):

Diego Colombo ◽

Federica Compostella ◽

Fiamma Ronchetti ◽

Shahrzad Reza-Elahi ◽

Antonio Scala ◽

...

Keyword(s):

Epstein Barr Virus ◽

Mouse Skin ◽

Tumor Promotion ◽

Inhibitory Effect ◽

Skin Tumor ◽

Barr Virus ◽

Epstein Barr

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Studies on Inhibitors of Skin Tumor Promotion, III. Inhibitory Effects of Isoflavonoids from Wisteria brachybotrys on Epstein-Barr Virus Activation

Journal of Natural Products ◽

10.1021/np50060a038 ◽

1988 ◽

Vol 51 (6) ◽

pp. 1266-1270 ◽

Cited By ~ 20

Author(s):

Takao Konoshima ◽

Emiko Okamoto ◽

Mutsuo Kozuka ◽

Hoyoku Nishino ◽

Harukuni Tokuda ◽

...

Keyword(s):

Epstein Barr Virus ◽

Tumor Promotion ◽

Skin Tumor ◽

Inhibitory Effects ◽

Barr Virus ◽

Epstein Barr

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Studies on Inhibitors of Skin-Tumor Promotion, I. Inhibitory Effects of Triterpenes from Euptelea polyandra on Epstein-Barr Virus Activation

Journal of Natural Products ◽

10.1021/np50054a031 ◽

1987 ◽

Vol 50 (6) ◽

pp. 1167-1170 ◽

Cited By ~ 32

Author(s):

Takao Konoshima ◽

Midori Takasaki ◽

Mutsuo Kozuka ◽

Harukuni Tokuda

Keyword(s):

Epstein Barr Virus ◽

Tumor Promotion ◽

Skin Tumor ◽

Inhibitory Effects ◽

Barr Virus ◽

Epstein Barr

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Cancer-chemopreventive effects of natural sweeteners and related compounds

Pure and Applied Chemistry ◽

10.1351/pac200274071309 ◽

2002 ◽

Vol 74 (7) ◽

pp. 1309-1316 ◽

Cited By ~ 34

Author(s):

Takao Konoshima ◽

Midori Takasaki

Keyword(s):

Mouse Skin ◽

Stevia Rebaudiana ◽

Chemical Carcinogenesis ◽

Inhibitory Effect ◽

Skin Carcinogenesis ◽

Inhibitory Effects ◽

Chemopreventive Agents ◽

Vitro Assay

To search for possible cancer-chemopreventive agents from natural resources, several natural sweeteners were screened by the in vitro assay indicated by the inhibitory effects of Epstein-Barr virus early antigen (EBV-EA) induction. Of active compounds that showed the remarkable inhibitory effects on the EBV-EA induction, stevioside, from the leaves of Stevia rebaudiana, and mogroside V, from the fruits of Momordica grosvenori, exhibited significant inhibitory effects on the two-stage mouse skin carcinogenesis in vivo induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). The inhibitory effect of stevioside is stronger than that of glycyrrhizin, which had been known as an antitumor-promoter in chemical carcinogenesis. Furthermore, stevioside also inhibited mouse skin carcinogenesis initiated by peroxynitrite. These results suggest that stevioside and mogroside V might be valuable as chemopreventive agents for chemical carcinogenesis.

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