Pediatric Acquired von Willebrand Disease With Berlin Heart Excor Ventricular Assist Device Support

2016 ◽  
Vol 7 (5) ◽  
pp. 614-618 ◽  
Author(s):  
Nathan Gossai ◽  
Nicholas M. Brown ◽  
Rebecca Ameduri ◽  
Nicole D. Zantek ◽  
James St. Louis ◽  
...  
2013 ◽  
Vol 146 (4) ◽  
pp. e30-e32 ◽  
Author(s):  
Karine Nubret ◽  
Philippe Mauriat ◽  
François Roubertie ◽  
Chloé James ◽  
Nadir Tafer ◽  
...  

Author(s):  
Michael E. Kiyatkin ◽  
Adam S. Faye ◽  
Tamas A. Gonda

In this chapter, the authors discuss the pathophysiology, diagnosis, and treatment of gastrointestinal bleeding (GIB) in the setting of left ventricular assist device (LVAD) support. Briefly, LVAD surgery has become widespread. Despite numerous advances, LVADs continue to be associated with a high incidence of GIB. The pathophysiology of this is multifactorial, with contributors including acquired von Willebrand disease and angiodysplasia. When GIB is suspected, it is imperative to consult a gastroenterologist and cardiologist. Endoscopy is the principal diagnostic and therapeutic modality. Occult GIB may be investigated with enteroscopy, capsule endoscopy, and angiography. Pharmacologic treatment may include a brief hold of anticoagulation and initiation of angiotensin-converting enzyme inhibitors, proton pump inhibitors, and octreotide, among other drugs. Evidence for pharmacotherapy, however, is limited. At the time of discharge, the focus should be on secondary prevention. In summary, LVAD-related GIB is a unique clinical problem that requires multimodal and multidisciplinary management.


Circulation ◽  
2013 ◽  
Vol 128 (11_suppl_1) ◽  
pp. S24-S31 ◽  
Author(s):  
P. Eghtesady ◽  
C. S. D. Almond ◽  
C. Tjossem ◽  
D. Epstein ◽  
M. Imamura ◽  
...  

2006 ◽  
Vol 81 (3) ◽  
pp. 1116-1118 ◽  
Author(s):  
Gansevoort H. Dunnington ◽  
Justin Sleasman ◽  
Abdulaziz Alkhaldi ◽  
Marc P. Pelletier ◽  
Bruce A. Reitz ◽  
...  

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