Human cutaneous leishmaniasis caused by Leishmania naiffi is wide-spread in South America

2002 ◽  
Vol 96 (8) ◽  
pp. 781-785 ◽  
Author(s):  
F. Pratlong ◽  
M. Deniau ◽  
H. Darie ◽  
S. Eichenlaub ◽  
S. Pröll ◽  
...  
Keyword(s):  
South America ◽  
Cutaneous Leishmaniasis ◽  
Wide Spread ◽  
Human Cutaneous Leishmaniasis

The expression of TLR9 in human cutaneous leishmaniasis is associated with granuloma

2010 ◽  
Vol 32 (11-12) ◽  
pp. 769-772 ◽  
Author(s):  
F. F. TUON ◽  
E. R. FERNANDES ◽  
C. PAGLIARI ◽  
M. I. S. DUARTE ◽  
V. S. AMATO
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Human Cutaneous Leishmaniasis

scholarly journals First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

2015 ◽  
Vol 45 (11) ◽  
pp. 679-684 ◽  
Author(s):  
Godwin Kwakye-Nuako ◽  
Mba-Tihssommah Mosore ◽  
Christopher Duplessis ◽  
Michelle D. Bates ◽  
Naiki Puplampu ◽  
...  
Keyword(s):  
New Species ◽  
Cutaneous Leishmaniasis ◽  
Leishmania Enriettii ◽  
Human Cutaneous Leishmaniasis ◽  
A New Species

Case Report: Miltefosine Failure and Spontaneous Resolution of Cutaneous Leishmaniasis braziliensis

2021 ◽  
Author(s):  
Sheridan Joseph ◽  
Timothy J. Whitman ◽  
Frederick S. Buckner ◽  
Anna L. Cogen
Keyword(s):  
Case Report ◽  
South America ◽  
Treatment Failure ◽  
Cutaneous Leishmaniasis ◽  
Young Woman ◽  
Spontaneous Resolution ◽  
Clinical Monitoring ◽  
Leishmania Braziliensis ◽  
Oral Medications ◽  
Mucocutaneous Leishmaniasis

Cutaneous leishmaniasis (CL) is often caused by Leishmania braziliensis (L. braziliensis) in South America. Because of the risk for mucocutaneous leishmaniasis, L. braziliensis is frequently treated with parenteral or oral medications. Here, we present a case of a young woman with L. braziliensis (CL) that did not respond to miltefosine but eventually experienced spontaneous resolution. This case highlights the potential for treatment failure and the importance of clinical monitoring in the setting of cutaneous leishmaniasis caused by L. braziliensis.

American cutaneous leishmaniasis in Guyana, South America

2001 ◽  
Vol 95 (3) ◽  
pp. 245-251 ◽  
Author(s):  
S. C. Rawlins ◽  
T. Tiwari ◽  
D. D. Chadee ◽  
L. Validum ◽  
H. Alexander ◽  
...  
Keyword(s):  
South America ◽  
Cutaneous Leishmaniasis ◽  
American Cutaneous Leishmaniasis

scholarly journals Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Lucio Roberto Castellano ◽  
Laurent Argiro ◽  
Helia Dessein ◽  
Alain Dessein ◽  
Marcos Vinícius da Silva ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Therapeutic Strategy ◽  
Interleukin 10 ◽  
Leishmania Braziliensis ◽  
Soluble Antigen ◽  
Innovative Strategies ◽  
Host Protection ◽  
Human Cutaneous Leishmaniasis ◽  
Potential Use ◽  
Worse Prognosis

Interleukin-10 overproduction has been associated with worse prognosis in human cutaneous leishmaniasis, while IFN-γ-dependent responses are associated with parasite killing and host protection. Innovative strategies are needed to overcome therapeutic failure observed in endemic areas. The use of monoclonal antibody-based immunotherapy targeting IL-10 cytokine was evaluated here. Partial IL-10 blockade inLeishmania braziliensiswhole soluble antigen-stimulated cells from endemic area CL patients with active or healed lesions and asymptomatic controls was evaluated. Overall decrease in IL-10, IL-4, and TNF-αproduction was observed in all groups of subjects. Only patients with active lesions still produced some levels of TNF-αafter anti-IL-10 stimulation in association withLeishmaniaantigens. Moreover, this strategy showed limited modulatory effects on IFN-γ-dependent chemokine CXCL10 production. Results suggest the potential immunotherapeutic use of partial IL-10 blockade in localized cutaneous leishmaniasis.

scholarly journals In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis

1996 ◽  
Vol 15 (2-3) ◽  
pp. 101-107 ◽  
Author(s):  
Peter C. Melby ◽  
Fernando Andrade-Narvaez ◽  
Barbara J. Darnell ◽  
Guillermo Valencia-Pacheco
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Interleukin 10 ◽  
Interleukin 12 ◽  
Human Cutaneous Leishmaniasis

Matrix Remodelling and Fibroblast Phenotype in Early Lesions of Human Cutaneous Leishmaniasis

1991 ◽  
Vol 187 (8) ◽  
pp. 924-930 ◽  
Author(s):  
P. Esterre ◽  
J.P. Dedet ◽  
S. Guerret ◽  
M. Chevallier ◽  
C. Frenay ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Early Lesions ◽  
Human Cutaneous Leishmaniasis

scholarly journals Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis

2010 ◽  
Vol 71 (12) ◽  
pp. 1220-1227 ◽  
Author(s):  
Ana P. Campanelli ◽  
Claudia I. Brodskyn ◽  
Viviane Boaventura ◽  
Claire Silva ◽  
Ana M. Roselino ◽  
...  
Keyword(s):  
Immune Response ◽  
Cutaneous Leishmaniasis ◽  
Chemokine Receptors ◽  
Inflammatory Immune Response ◽  
Human Cutaneous Leishmaniasis

Human Cutaneous Leishmaniasis Acquired in Texas *

1985 ◽  
Vol 34 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Tracy L. Gustafson ◽  
Phillip G. Lawyer ◽  
Christie M. Reed ◽  
Patrick B. McGreevy ◽  
Michael G. Pappas ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Human Cutaneous Leishmaniasis
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