Effect of Interleukin-2 on Generation of Natural Killer Cells: Role of Major Histocompatibility Complex Class I in B6 and TAP-1-/-Mice

2000 ◽  
Vol 12 (2) ◽  
pp. 160-166
Author(s):  
D.V. Delfino ◽  
B. Di Marco ◽  
C. Marchetti ◽  
A. Bartoli ◽  
E. Ayroldi ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Natural Killer Cells ◽  
Major Histocompatibility Complex Class ◽  
Natural Killer ◽  
Interleukin 2 ◽  
Class I ◽  
Complex Class ◽  
Killer Cells ◽  
Histocompatibility Complex

Licensing of natural killer cells by host major histocompatibility complex class I molecules

Nature ◽  
2005 ◽  
Vol 436 (7051) ◽  
pp. 709-713 ◽  
Author(s):  
Sungjin Kim ◽  
Jennifer Poursine-Laurent ◽  
Steven M. Truscott ◽  
Lonnie Lybarger ◽  
Yun-Jeong Song ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Natural Killer Cells ◽  
Major Histocompatibility Complex Class ◽  
Natural Killer ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Killer Cells ◽  
Histocompatibility Complex

scholarly journals Major Histocompatibility Complex Class I Chain–Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais

2020 ◽  
Vol 222 (5) ◽  
pp. 840-846
Author(s):  
Panpimon Luangtrakool ◽  
Sasijit Vejbaesya ◽  
Komon Luangtrakool ◽  
Somporn Ngamhawornwong ◽  
Kusuma Apisawes ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Natural Killer Cells ◽  
Major Histocompatibility Complex Class ◽  
Natural Killer ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Replication Cohort ◽  
Killer Cells ◽  
Histocompatibility Complex

Abstract Background Major histocompatibility complex class I chain–related (MIC) A and B (MICA and MICB) are polymorphic stress molecules recognized by natural killer cells. This study was performed to analyze MIC gene profiles in hospitalized Thai children with acute dengue illness. Methods MIC allele profiles were determined in a discovery cohort of patients with dengue fever or dengue hemorrhagic fever (DHF) (n = 166) and controls (n = 149). A replication cohort of patients with dengue (n = 222) was used to confirm specific MICB associations with disease. Results MICA*045 and MICB*004 associated with susceptibility to DHF in secondary dengue virus (DENV) infections (odds ratio [OR], 3.22; [95% confidence interval (CI), 1.18–8.84] and 1.99 [1.07–2.13], respectively), and MICB*002 with protection from DHF in secondary DENV infections (OR, 0.41; 95% CI, .21–.68). The protective effect of MICB*002 against secondary DHF was confirmed in the replication cohort (OR, 0.43; 95% CI, .22–.82) and was stronger when MICB*002 is present in individuals also carrying HLA-B*18, B*40, and B*44 alleles which form the B44 supertype of functionally related alleles (0.29, 95% CI, .14–.60). Conclusions Given that MICB*002 is a low expresser of soluble proteins, these data indicate that surface expression of MICB*002 with B44 supertype alleles on DENV-infected cells confer a protective advantage in controlling DENV infection using natural killer cells.

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