LSC Abstract – Systems approach to predict asthmatic response to allergen inhalation challenge

2016 ◽  
Author(s):  
Scott Tebbutt ◽  
Amrit Singh ◽  
Casey Shannon ◽  
Young Woong Kim ◽  
Mari DeMarco ◽  
...  
Keyword(s):  
Systems Approach ◽  
Asthmatic Response ◽  
Allergen Inhalation ◽  
Inhalation Challenge ◽  
Allergen Inhalation Challenge

scholarly journals Allergen-induced airway responses

2015 ◽  
Vol 46 (3) ◽  
pp. 819-831 ◽  
Author(s):  
Gail M. Gauvreau ◽  
Amani I. El-Gammal ◽  
Paul M. O'Byrne
Keyword(s):  
Early Response ◽  
Myeloid Dendritic Cells ◽  
Clinical Model ◽  
Allergen Inhalation ◽  
Chemotactic Factors ◽  
Inhalation Challenge ◽  
Airway Responses ◽  
Neutral Proteases ◽  
Allergen Inhalation Challenge

Environmental allergens are an important cause of asthma and can contribute to loss of asthma control and exacerbations. Allergen inhalation challenge has been a useful clinical model to examine the mechanisms of allergen-induced airway responses and inflammation. Allergen bronchoconstrictor responses are the early response, which reaches a maximum within 30 min and resolves by 1–3 h, and late responses, when bronchoconstriction recurs after 3–4 h and reaches a maximum over 6–12 h. Late responses are followed by an increase in airway hyperresponsiveness. These responses occur when IgE on mast cells is cross-linked by an allergen, causing degranulation and the release of histamine, neutral proteases and chemotactic factors, and the production of newly formed mediators, such as cysteinyl leukotrienes and prostaglandin D2. Allergen-induced airway inflammation consists of an increase in airway eosinophils, basophils and, less consistently, neutrophils. These responses are mediated by the trafficking and activation of myeloid dendritic cells into the airways, probably as a result of the release of epithelial cell-derived thymic stromal lymphopoietin, and the release of pro-inflammatory cytokines from type 2 helper T-cells. Allergen inhalation challenge has also been a widely used model to study potential new therapies for asthma and has an excellent negative predictive value for this purpose.

Is the allergen-inhalation challenge predictive of the severity of seasonal asthmatic exacerbations?

Allergy ◽  
1993 ◽  
Vol 48 (3) ◽  
pp. 202-206 ◽  
Author(s):  
E. Crimi ◽  
A. Balbo ◽  
S. Voltolini ◽  
C. Troise ◽  
V. Brusasco ◽  
...  
Keyword(s):  
Allergen Inhalation ◽  
Inhalation Challenge ◽  
Allergen Inhalation Challenge

Airway Eosinophilic Inflammation and Bronchial Hyperresponsiveness after Allergen Inhalation Challenge in Asthma

Lung ◽  
1998 ◽  
Vol 176 (4) ◽  
pp. 237-247 ◽  
Author(s):  
S. Oddera ◽  
M. Silvestri ◽  
R. Penna ◽  
G. Galeazzi ◽  
E. Crimi ◽  
...  
Keyword(s):  
Bronchial Hyperresponsiveness ◽  
Eosinophilic Inflammation ◽  
Allergen Inhalation ◽  
Inhalation Challenge ◽  
Allergen Inhalation Challenge

Allergen inhalation challenge in smoking compared with non-smoking asthmatic subjects

2011 ◽  
Vol 41 (8) ◽  
pp. 1084-1090 ◽  
Author(s):  
Z. Meghji ◽  
B. Dua ◽  
R. M. Watson ◽  
G. M. Gauvreau ◽  
P. M. O'Byrne
Keyword(s):  
Allergen Inhalation ◽  
Inhalation Challenge ◽  
Allergen Inhalation Challenge

Bronchial and cutaneous responses in atopic dermatitis patients after allergen inhalation challenge

1997 ◽  
Vol 27 (9) ◽  
pp. 1043-1051 ◽  
Author(s):  
L. BRINKMAN ◽  
M. M. ASLANDER ◽  
J. A. M. RAAIJMAKERS ◽  
J.-W. J. LAMMERS ◽  
L. KOENDERMAN ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Allergen Inhalation ◽  
Inhalation Challenge ◽  
Allergen Inhalation Challenge

Protective effect of lodoxamide tromethamine on allergen inhalation challenge

1980 ◽  
Vol 66 (4) ◽  
pp. 286-294 ◽  
Author(s):  
Gavin D. Watt ◽  
Tiet C. Bui ◽  
Againdra K. Bewtra ◽  
Robert G. Townley
Keyword(s):  
Protective Effect ◽  
Allergen Inhalation ◽  
Inhalation Challenge ◽  
Allergen Inhalation Challenge
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