scholarly journals Local search for the generalized tree alignment problem

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Andrés Varón ◽  
Ward C Wheeler
2021 ◽  
Vol 26 ◽  
pp. 1-32
Author(s):  
Zirou Qiu ◽  
Ruslan Shaydulin ◽  
Xiaoyuan Liu ◽  
Yuri Alexeev ◽  
Christopher S. Henry ◽  
...  

Networks model a variety of complex phenomena across different domains. In many applications, one of the most essential tasks is to align two or more networks to infer the similarities between cross-network vertices and to discover potential node-level correspondence. In this article, we propose ELRUNA ( el imination ru le-based n etwork a lignment), a novel network alignment algorithm that relies exclusively on the underlying graph structure. Under the guidance of the elimination rules that we defined, ELRUNA computes the similarity between a pair of cross-network vertices iteratively by accumulating the similarities between their selected neighbors. The resulting cross-network similarity matrix is then used to infer a permutation matrix that encodes the final alignment of cross-network vertices. In addition to the novel alignment algorithm, we improve the performance of local search , a commonly used postprocessing step for solving the network alignment problem, by introducing a novel selection method RAWSEM ( ra ndom- w alk-based se lection m ethod) based on the propagation of vertices’ mismatching across the networks. The key idea is to pass on the initial levels of mismatching of vertices throughout the entire network in a random-walk fashion. Through extensive numerical experiments on real networks, we demonstrate that ELRUNA significantly outperforms the state-of-the-art alignment methods in terms of alignment accuracy under lower or comparable running time. Moreover, ELRUNA is robust to network perturbations such that it can maintain a close-to-optimal objective value under a high level of noise added to the original networks. Finally, the proposed RAWSEM can further improve the alignment quality with a smaller number of iterations compared with the naive local search method. Reproducibility : The source code and data are available at https://tinyurl.com/uwn35an.


1997 ◽  
Vol 4 (3) ◽  
pp. 415-431 ◽  
Author(s):  
BENNO SCHWIKOWSKI ◽  
MARTIN VINGRON

2017 ◽  
Author(s):  
Michela Quadrini ◽  
Luca Tesei ◽  
Emanuela Merelli ◽  

The methods proposed in the literature for RNA comparison focus mainly on pseudoknot free structures. The comparison of pseudoknotted structures is still a challenge. In this work, we propose a new algebraic representation of RNA secondary structures based on relations among hairpins in terms of nesting, crossing, and concatenation. Such algebraic representation is obtained from a defined multiple context-free grammar, which maps any kind of RNA secondary structures into extended trees, i.e., ordered trees where internal nodes are labeled with algebraic operators and leaves are labeled with loops. These extended trees permit the definition of the RNA secondary structure comparison as a tree alignment problem.


2017 ◽  
Author(s):  
Michela Quadrini ◽  
Luca Tesei ◽  
Emanuela Merelli ◽  

The methods proposed in the literature for RNA comparison focus mainly on pseudoknot free structures. The comparison of pseudoknotted structures is still a challenge. In this work, we propose a new algebraic representation of RNA secondary structures based on relations among hairpins in terms of nesting, crossing, and concatenation. Such algebraic representation is obtained from a defined multiple context-free grammar, which maps any kind of RNA secondary structures into extended trees, i.e., ordered trees where internal nodes are labeled with algebraic operators and leaves are labeled with loops. These extended trees permit the definition of the RNA secondary structure comparison as a tree alignment problem.


2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Andrés Varón ◽  
Ward C Wheeler

Cladistics ◽  
2015 ◽  
Vol 32 (4) ◽  
pp. 452-460 ◽  
Author(s):  
Eric Ford ◽  
Ward C. Wheeler

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