scholarly journals Up-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept

2014 ◽  
Vol 12 (1) ◽  
pp. 89 ◽  
Author(s):  
Claudia Kusmic ◽  
Cristina Barsanti ◽  
Marco Matteucci ◽  
Nicoletta Vesentini ◽  
Gualtiero Pelosi ◽  
...  
Keyword(s):  
Infarct Size ◽  
Experimental Evidence ◽  
Heme Oxygenase ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Heme Oxygenase 1 ◽  
Proof Of Concept ◽  
Evidence And Proof

scholarly journals Splenic Ly6Chi monocytes contribute to adverse late post-ischemic left ventricular remodeling in heme oxygenase-1 deficient mice

2017 ◽  
Vol 112 (4) ◽  
Author(s):  
Mateusz Tomczyk ◽  
Izabela Kraszewska ◽  
Krzysztof Szade ◽  
Karolina Bukowska-Strakova ◽  
Marco Meloni ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Heme Oxygenase 1 ◽  
Deficient Mice

Texture-based machine learning in LGE-CMRI for automatic scar assessment

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
V.F Froysa ◽  
G.J.B Jansson ◽  
T.E Eftestol ◽  
L.W Woie ◽  
S.O Orn
Keyword(s):  
Machine Learning ◽  
Infarct Size ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Lower Probability ◽  
Funding Source ◽  
Size Estimation ◽  
Scar Assessment ◽  
Scar Size

Abstract Background Conventional methods for the estimation of infarct size by late-enhanced cardiac magnetic resonance imaging use analyzes from each slice which in turn is added to generate a volume. We present a novel method based on machine learning, called texture based probability mapping (TPM). TPM is based upon expressing the probability of scarring in a pixel based upon analysing textural information in patches around each pixel. Purpose To explore our method and assess its utility as a tool to scar size and compare it with four established methods. Methods In 54 patients with ischemic scars, our method was compared with four 2D methods. 2 patients were excluded due to low image quality and artefacts. The most basal and apical short axis image slices were exclude due to partial volume artefacts. Myocardial infarction (MI) size was estimated manually, and TPM performed. Cardiac segments were defined as myocardial regions with pixel probabilities within a specified range. By varying the lower probability threshold while keeping the upper threshold fixed at 1, different cardiac segments were defined. Using the Sørensen-Dice coefficient the optimal probability range with the highest correlation to manual estimation of infarct size was identified. Results TPM-range 0.341–1.0 is best correlated to manual demarcation (median Dice 0.70). The method demonstrated stronger correlations between scar size and left ventricular remodeling parameters (LV ejection fraction: r=−0.731, p<0.0005; LV end-diastolic volume: r=0.641, p<0.0005; LV end-systolic volume: r=0.672, p<0.0005) compared with manual method. Conclusion Using TPM, infarct size can be measured automatically without using signal intensity as a reference value. It is without the need for manual demarcation of the scar and is less time consuming and less vulnerable to interobserver variability. It has a strong correlation with left ventricular remodeling parameters crucial in guiding further medical therapy. The use of this method is however not primarily dedicated for scar size estimation, but a tool to evaluate different properties of the tissue that cannot be visualized by the naked eye. It's an important step towards better understanding of myocardial damage pattern causing ventricular arrhythmia and SCD. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Helse Vest

scholarly journals Effects of (−)-Epicatechin on Myocardial Infarct Size and Left Ventricular Remodeling After Permanent Coronary Occlusion

2010 ◽  
Vol 55 (25) ◽  
pp. 2869-2876 ◽  
Author(s):  
Katrina Go Yamazaki ◽  
Pam R. Taub ◽  
Maraliz Barraza-Hidalgo ◽  
Maria M. Rivas ◽  
Alexander C. Zambon ◽  
...  
Keyword(s):  
Infarct Size ◽  
Coronary Occlusion ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Myocardial Infarct ◽  
Left Ventricular ◽  
Myocardial Infarct Size

scholarly journals Myeloperoxidase-Generated Oxidants Modulate Left Ventricular Remodeling but Not Infarct Size After Myocardial Infarction

Circulation ◽  
2005 ◽  
Vol 112 (18) ◽  
pp. 2812-2820 ◽  
Author(s):  
Nikolay Vasilyev ◽  
Timothy Williams ◽  
Marie-Luise Brennan ◽  
Samuel Unzek ◽  
Xiaorong Zhou ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Infarct Size ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular

Effects of intracoronary delivery of allogenic bone marrow-derived stem cells expressing heme oxygenase-1 on myocardial reperfusion injury

2012 ◽  
Vol 108 (09) ◽  
pp. 464-475 ◽  
Author(s):  
Michal Tendera ◽  
Wieslaw Cybulski ◽  
Ewa K. Zuba-Surma ◽  
Krzysztof Szade ◽  
Urszula Florczyk ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Infarct Size ◽  
Heme Oxygenase ◽  
Bone Marrow Cells ◽  
Left Ventricular ◽  
Balloon Occlusion ◽  
Heme Oxygenase 1 ◽  
Infarct Zone ◽  
Allogenic Bone ◽  
Allogenic Bone Marrow

SummaryHeme oxygenase-1 (HO-1) decreases apoptosis, inflammation and oxidative stress. The aim of the study was to investigate the effects of intracoronary infusion of allogenic bone marrow cells (BMC) overexpressing HO-1 in the porcine model of myocardial infarction (MI). MI was produced by balloon occlusion of a coronary artery. BMC were transduced with adenoviruses encoding for HO-1 (HO-1 BMC) or GFP (GFP-BMC) genes. Prior to reperfusion animals received HO-1 BMC, control BMC (unmodified or GFP-BMC) or placebo. Left ventricular (LV) ejection fraction (EF), shortening fraction (SF), end-systolic and enddiastolic diameters (EDD, ESD) were assessed by echocardiography before, 30 minutes (min) and 14 days after reperfusion. BMC significantly improved LVEF and SF early (30 min) after reperfusion as well as after 14 days. Early after reperfusion HO-1 BMC were significantly more effective than control BMC, but after 14 days, there were no differences. There were no effect of cells on LV remodelling and diastolic function. Both HO-1 BMC and control BMC significantly reduced the infarct size vs. placebo (17.2 ± 2.7 and 18.8 ± 2.5, respectively, vs. 27.5 ± 5.1, p= 0.02) in histomorphometry. HO-1-positive donor BMC were detected in the infarct border area in pigs receiving HO-1-cells. No significant differences in expression of inflammatory genes (SDF-1, TNF-α, IL-6, miR21, miR29a and miR133a) in the myocardium were found. In conclusion, intracoronary delivery of allogeneic BMC immediately prior to reperfusion improved the LVEF and reduced the infarct size. HO-1 BMC were not superior to control cells after 14 days, however, produced faster recovery of LVEF. Transplanted cells survived in the peri-infarct zone.

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