Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation

G Protein Signaling ◽

Protein Signaling ◽

Alterations in Metabotropic Glutamate Receptor 1α and Regulator of G Protein Signaling 4 in the Prefrontal Cortex in Schizophrenia

American Journal of Psychiatry ◽

10.1176/appi.ajp.2010.10030318 ◽

2010 ◽

Vol 167 (12) ◽

pp. 1489-1498 ◽

Cited By ~ 83

Author(s):

David W. Volk ◽

Stephen M. Eggan ◽

David A. Lewis

Keyword(s):

Prefrontal Cortex ◽

G Protein ◽

Glutamate Receptor ◽

G Protein Signaling ◽

Protein Signaling ◽

Regulator of G-Protein Signaling 4 Interacts with Metabotropic Glutamate Receptor Subtype 5 in Rat Striatum: Relevance to Amphetamine Behavioral Sensitization

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.128561 ◽

2007 ◽

Vol 323 (2) ◽

pp. 650-657 ◽

Cited By ~ 28

Author(s):

Marek Schwendt ◽

Jacqueline F. McGinty

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Behavioral Sensitization ◽

Rat Striatum ◽

Receptor Subtype ◽

G Protein Signaling ◽

Protein Signaling ◽

A Retinal-Specific Regulator of G-Protein Signaling Interacts with G o and Accelerates an Expressed Metabotropic Glutamate Receptor 6 Cascade

Journal of Neuroscience ◽

10.1523/jneurosci.0492-04.2004 ◽

2004 ◽

Vol 24 (25) ◽

pp. 5684-5693 ◽

Cited By ~ 37

Author(s):

A. Dhingra

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

G Protein Signaling ◽

Protein Signaling ◽

G Protein-coupled Receptor Kinase 2 Regulator of G Protein Signaling Homology Domain Binds to Both Metabotropic Glutamate Receptor 1a and Gαqto Attenuate Signaling

Journal of Biological Chemistry ◽

10.1074/jbc.m314090200 ◽

2004 ◽

Vol 279 (16) ◽

pp. 16614-16620 ◽

Cited By ~ 61

Author(s):

Gurpreet K. Dhami ◽

Lianne B. Dale ◽

Pieter H. Anborgh ◽

Katharine E. O'Connor-Halligan ◽

Rachel Sterne-Marr ◽

...

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

G Protein Signaling ◽

Protein Signaling ◽

Receptor Kinase ◽

Metabotropic Glutamate ◽

Faculty Opinions recommendation of Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732704940.793543297 ◽

2018 ◽

Author(s):

Dario Doller

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

X Ray ◽

Metabotropic Glutamate ◽

Metabotropic glutamate 2,3 receptor stimulation desensitizes agonist activation of G‐protein signaling and alters transcription regulators in mesocorticolimbic brain regions

Synapse ◽

10.1002/syn.22190 ◽

2020 ◽

Author(s):

Carolina Burgos‐Aguilar ◽

Mark J. Ferris ◽

Lacey L. Sexton ◽

Haiguo Sun ◽

Ruoyu Xiao ◽

...

Keyword(s):

G Protein ◽

Brain Regions ◽

G Protein Signaling ◽

Protein Signaling ◽

Receptor Stimulation ◽

Metabotropic Glutamate ◽

Transcription Regulators

The G‐protein‐coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1

The FASEB Journal ◽

10.1096/fj.00-0072com ◽

2000 ◽

Vol 14 (15) ◽

pp. 2569-2580 ◽

Cited By ~ 94

Author(s):

Michele Sallese ◽

Lorena Salvatore ◽

Etrusca D'Urbano ◽

Gianluca Sala ◽

Marianna Storto ◽

...

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Receptor Kinase ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 1 ◽

G Protein Coupled ◽

Homologous Desensitization

G Protein-coupled Receptor Kinase-mediated Desensitization of Metabotropic Glutamate Receptor 1A Protects against Cell Death

Journal of Biological Chemistry ◽

10.1074/jbc.m006075200 ◽

2000 ◽

Vol 275 (49) ◽

pp. 38213-38220 ◽

Cited By ~ 91

Author(s):

Lianne B. Dale ◽

Moshmi Bhattacharya ◽

Pieter H. Anborgh ◽

Barbara Murdoch ◽

Mickie Bhatia ◽

...

Keyword(s):

Cell Death ◽

G Protein ◽

Glutamate Receptor ◽

Receptor Kinase ◽

Metabotropic Glutamate ◽

Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b01722 ◽

2018 ◽

Vol 62 (1) ◽

pp. 207-222 ◽

Cited By ~ 34

Author(s):

John A. Christopher ◽

Zoltán Orgován ◽

Miles Congreve ◽

Andrew S. Doré ◽

James C. Errey ◽

...

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

X Ray ◽

Metabotropic Glutamate ◽

Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.89.17.8040 ◽

1992 ◽

Vol 89 (17) ◽

pp. 8040-8044 ◽

Cited By ~ 23

Author(s):

L. Prezeau ◽

O. Manzoni ◽

V. Homburger ◽

F. Sladeczek ◽

K. Curry ◽

...

Keyword(s):

Adenylyl Cyclase ◽

G Protein ◽

Glutamate Receptor ◽

Pertussis Toxin ◽

Metabotropic Glutamate ◽

Negative Coupling