scholarly journals Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury

2013 ◽  
Vol 6 (1) ◽  
pp. 3 ◽  
Author(s):  
Soraya Nishimura ◽  
Akimasa Yasuda ◽  
Hiroki Iwai ◽  
Morito Takano ◽  
Yoshiomi Kobayashi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Therapeutic Potential ◽  
Time Dependent ◽  
Injured Spinal Cord ◽  
Cord Injury

Stem Cell Transplantation: A Promising Therapy for Spinal Cord Injury

2020 ◽  
Vol 15 (4) ◽  
pp. 321-331 ◽  
Author(s):  
Zhe Gong ◽  
Kaishun Xia ◽  
Ankai Xu ◽  
Chao Yu ◽  
Chenggui Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Potential ◽  
Embryonic Stem ◽  
Current Status ◽  
Cord Injury

Spinal Cord Injury (SCI) causes irreversible functional loss of the affected population. The incidence of SCI keeps increasing, resulting in huge burden on the society. The pathogenesis of SCI involves neuron death and exotic reaction, which could impede neuron regeneration. In clinic, the limited regenerative capacity of endogenous cells after SCI is a major problem. Recent studies have demonstrated that a variety of stem cells such as induced Pluripotent Stem Cells (iPSCs), Embryonic Stem Cells (ESCs), Mesenchymal Stem Cells (MSCs) and Neural Progenitor Cells (NPCs) /Neural Stem Cells (NSCs) have therapeutic potential for SCI. However, the efficacy and safety of these stem cellbased therapy for SCI remain controversial. In this review, we introduce the pathogenesis of SCI, summarize the current status of the application of these stem cells in SCI repair, and discuss possible mechanisms responsible for functional recovery of SCI after stem cell transplantation. Finally, we highlight several areas for further exploitation of stem cells as a promising regenerative therapy of SCI.

scholarly journals A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury

2018 ◽  
Vol 22 (6) ◽  
pp. 941-950.e6 ◽  
Author(s):  
Erik Curtis ◽  
Joel R. Martin ◽  
Brandon Gabel ◽  
Nikki Sidhu ◽  
Teresa K. Rzesiewicz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Phase I ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Phase I Study ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

Pain with no gain: Allodynia following neural stem cell transplantation in spinal cord injury

2006 ◽  
Vol 201 (2) ◽  
pp. 335-348 ◽  
Author(s):  
M MACIAS ◽  
M SYRING ◽  
M PIZZI ◽  
M CROWE ◽  
A ALEXANIAN ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Cord Injury

scholarly journals Neural stem cell transplantation combined with erythropoietin for the treatment of spinal cord injury in rats

2016 ◽  
Vol 12 (4) ◽  
pp. 2688-2694 ◽  
Author(s):  
Yan Zhao ◽  
Yuan Zuo ◽  
Jianming Jiang ◽  
Huibo Yan ◽  
Xiliang Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Cord Injury
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