scholarly journals Tacrolimus trough levels in kidney transplant recipients

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Young Hui Hwang ◽  
Hyunjung Kim ◽  
Kyungok Min ◽  
Jaeseok Yang
Keyword(s):  
Kidney Transplant ◽  
Graft Rejection ◽  
Immunosuppressive Drugs ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Factors Affecting ◽  
Multivariable Regression ◽  
Trough Levels ◽  
Tacrolimus Dose ◽  
Dose Change

Abstract Background It is very important that kidney transplant recipients (KTRs) take immunosuppressive drugs to prevent graft rejection. This study aimed to identify the tacrolimus trough levels (TTL)-mean, TTL-standard deviation (SD), and TTL- coefficient of variation (CV) as well as factors affecting these values over a 2-year period in clinically stable patients > 5 years after kidney transplantation (KT). Methods This retrospective study analyzed data from 248 adult outpatients > 5 years after KT. Medical chart data, including TTL, graft rejection, and tacrolimus dose change during a 2-year period, between January 2017 and December 2018, were collected. Multivariable regression analyses were conducted to determine the factors influencing the TTL-mean, TTL-SD, and TTL-CV. Results The TTL-mean, TTL-SD, and TTL-CV were 6.00 ± 1.07 ng/mL, 1.51 ± 1.09 ng/mL, and 0.25 ± 0.14, respectively. The TTL-mean, TTL-SD, and TTL-CV did not differ according to sex, type of donor, retransplant, pretransplant kidney disease, body mass index, or posttransplant time; hence, they are stable in kidney transplant recipients > 5 years after KT. The higher the TTL-mean, the higher the TTL-SD. Age and the TTL-SD significantly predicted the TTL-mean (p < .001). Tacrolimus dose change and the TTL-mean significantly predicted the TTL-SD (p < .001). Tacrolimus dose change significantly predicted the TTL-CV (p = .008). Conclusion In clinically stable KTRs, TTL-SD and TTL-CV change sensitively in relation to tacrolimus dose changes. Therefore, changes in TTL-SD and TTL-CV in stable KTRs with no tacrolimus dose change require medical interest and attention.

Extracorporeal photopheresis for the treatment of graft rejection in 33 adult kidney transplant recipients

2019 ◽  
Vol 58 (4) ◽  
pp. 515-524
Author(s):  
Mathilde Tamain ◽  
Johnny Sayegh ◽  
Arnaud Lionet ◽  
Philippe Grimbert ◽  
Carole Philipponnet ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Graft Rejection ◽  
Extracorporeal Photopheresis ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Adult Kidney

Role of Maraviroc in minimizing the risk of graft rejection in HIV‐infected kidney transplant recipients

2020 ◽  
Vol 22 (4) ◽  
Author(s):  
Gaetano Alfano ◽  
Giovanni Guaraldi ◽  
Francesco Fontana ◽  
Erica Franceschini ◽  
Giovanni Dolci ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Graft Rejection ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Tacrolimus trough levels higher than 6 ng/mL might not be required after a year in stable kidney transplant recipients

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0235418
Author(s):  
Hee-Yeon Jung ◽  
Min Young Seo ◽  
Yena Jeon ◽  
Kyu Ha Huh ◽  
Jae Berm Park ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Trough Levels

Pretransplant Tacrolimus Dose Requirements Predict Early Posttransplant Dose Requirements in Blood Group AB0-Incompatible Kidney Transplant Recipients

2016 ◽  
Vol 38 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Nauras Shuker ◽  
Femke M. de Man ◽  
Annelies E. de Weerd ◽  
Madelon van Agteren ◽  
Willem Weimar ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Blood Group ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Tacrolimus Dose

Long-term genotoxic effects of immunosuppressive drugs on lymphocytes of kidney transplant recipients

2016 ◽  
Vol 806 ◽  
pp. 47-52 ◽  
Author(s):  
Heloísa Lizotti Cilião ◽  
Rossana Batista de Oliveira Camargo-Godoy ◽  
Gustavo Rafael Mazzaron Barcelos ◽  
Amanda Zanuto ◽  
Vinicius Daher Alvares Delfino ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Immunosuppressive Drugs ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Genotoxic Effects

scholarly journals Vitamin B12 status in kidney transplant recipients: association with dietary intake, body adiposity and immunosuppression

2019 ◽  
Vol 122 (04) ◽  
pp. 450-458
Author(s):  
Karine Scanci da Silva Pontes ◽  
Márcia Regina Simas Torres Klein ◽  
Mariana Silva da Costa ◽  
Kelli Trindade de Carvalho Rosina ◽  
Ana Paula Medeiros Menna Barreto ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Kidney Transplant ◽  
Intrinsic Factor ◽  
Immunosuppressive Drugs ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Body Adiposity ◽  
Deficient Group

AbstractThe aim of the present study was to evaluate the prevalence of vitamin B12(B12) deficiency in kidney transplant recipients (KTR) and its possible association with B12dietary intake, body adiposity and immunosuppressive drugs. In this cross-sectional study, we included 225 KTR, aged 47·50 (sd12·11) years, and 125 (56 %) were men. Serum levels of B12were determined by chemiluminescent microparticle intrinsic factor assay and the cut-off of 200 pg/ml was used to stratify KTR into B12-sufficient or B12-deficient group. B12dietary intake was evaluated by three 24 h dietary recalls and was considered adequate when ≥2·4 μg/d. Body adiposity was estimated after taking anthropometric measures and using the dual-energy X-ray absorptiometry (DXA) method. B12deficiency was seen in 14 % of the individuals. B12-deficient group, compared with the B12-sufficient group, exhibited lower intake of B12(median 2·42 (interquartile range (IQR) 1·41–3·23)v. 3·16 (IQR 1·94–4·55) μg/d,P= 0·04) and higher values of waist circumference (median 96·0 (IQR 88·0–102·5)v. 90·0 (IQR 82·0–100·0) cm,P= 0·04). When the analysis included only women, B12deficiency was associated with higher total and central body adiposity measurements obtained with anthropometry (BMI, body adiposity index, waist and neck circumferences) and DXA (total and trunk body fat). Among individuals with adequate intake of B12, the deficiency of this vitamin was more frequently seen in those using mycophenolate mofetil (MMF) (17 %)v. azathioprine (2 %),P= 0·01. In conclusion, the prevalence of B12deficiency in KTR was estimated as 14 % and was associated with reduced intake of B12as well as higher adiposity, especially in women, and with the use of MMF.

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