scholarly journals Peripapillary vessel density measurement of quadrant and clock-hour sectors in primary angle closure glaucoma using optical coherence tomography angiography

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yongdong Lin ◽  
Shirong Chen ◽  
Mingzhi Zhang
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
Angle Closure ◽  
Optical Coherence ◽  
Diagnostic Ability ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Rnfl Thickness ◽  
Inferior Quadrant

Abstract Background The purpose of this study was to investigate diagnostic ability of peripapillary vessel density of primary angle closure glaucoma (PACG) eyes in quadrant and clock-hour sectors by optical coherence tomography angiography (OCTA). Methods This was a cross-sectional study on forty-one PACG patients (41eyes) and twenty-seven healthy subjects (27 eyes). All subjects underwent OCTA (DRI OCT Triton; Topcon Corporation, Tokyo, Japan) and peripapillary retinal nerve fiber layer (RNFL) thickness imaging with swept-source optical coherence tomography (OCT). The peripapillary vessel density of quadrant and clock-hour sectors was quantified by imageJ software. The diagnostic capability of OCTA and OCT parameters was evaluated by the areas under the receiver operating characteristics curves (AUCs). Pearson correlation analysis or Spearman correlation test was used to evaluate the correlation between vessel density parameters and related factors. Results Compared with the control group, the peripapillary vessel density of glaucomatous group was lower to different degrees in the four quadrants and each clock-hour sectors, and vessel density reduced most at 7 o’clock. The difference between the diagnostic ability of peripapillary vessel density and peripapillary RNFL thickness was not statistically significant, except 4 o’clock and inferior quadrant. The inferior quadrant peripapillary vessel density had the best diagnostic value (AUC0.969), followed by the 7 o’clock vessel density (AUC0.964), average vessel density (AUC0.939) and the 7 o’clock RNFL thickness (AUC0.919). The average peripapillary vessel density was correlated with average RNFL and visual field (VF) mean deviation (P < 0.001). Conclusions In PACG, the diagnostic ability of the peripapillary vessel density is equivalent to the peripapillary RNFL thickness. Understanding spatial characteristics of the peripapillary vessel density in PACG may be helpful for clinical diagnosis and monitoring the progress of diseases.

scholarly journals Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ruyue Shen ◽  
Yu Meng Wang ◽  
Carol Y. Cheung ◽  
Poemen P. Chan ◽  
Clement C. Tham
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Disease Severity ◽  
Optical Coherence Tomography Angiography ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Rnfl Thickness

AbstractTo investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369 ± 0.781%) compared with PACG eyes (55.389 ± 0.721%, P = 0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis revealed that, for PACG and NTG eyes, decreased cpVD ([PACG] β = −4.242; CI: −8.120, −0.363 vs [NTG] β = −5.531; CI: −9.472, −1.590) and cpFD ([PACG] β = −8.894;CI: −11.925, −5.864 vs [NTG] β = −12.064; CI: −17.095, −6.932) were associated with decreased RNFL thickness (all P ≤ 0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (P = 0.028). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (β = −0.707; CI: −1.090, −0.324; P ≤ 0.001) and not associated with the visual field parameters in PACG eyes. Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.

scholarly journals Optical Coherence Tomography Angiography of The Macular Microcirculation in Acute Primary Angle Closure Treated With Phacoemulsification

2021 ◽  
Author(s):  
Lin Fu ◽  
Yau Kei Chan ◽  
Jia Fang ◽  
Junbo Liu ◽  
Shumei Wen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
Angle Closure ◽  
Field Pattern ◽  
Control Group ◽  
Optical Coherence ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure ◽  
Normal Individuals

Abstract Purpose To measure the changes of macular microcirculation in cases with unilateral acute primary angle closure (APAC) who were managed by phacoemulsification. Methods Patients with unilateral APAC and managed by phacoemulsification were enrolled. The contralateral unaffected eyes were served as fellow group, and normal individuals were recruited as control group. Optical coherence tomography angiography (OCT-A) was performed to analyse the macular whole image vessel density (wiVD) and parafoveal vessel density (pfVD). The retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses were assessed using spectral-domain optical coherence tomography. Results A total of 36 APAC patients and 35 eyes from 35 normal individuals were recruited. In the APAC eyes, the mean wiVD (42.1% ± 3.7%) and pfVD (45.2% ± 3.8%) in the superficial layers (wiVD-SL and pfVD-SL) were both significantly reduced, compared to fellow eyes (45.7% ± 3.1%, 48.7% ±3.1%) and control eyes (44.4% ± 4.7%, 47.4% ± 5.1%) (P < 0.05). They were all statistically correlated with RNFL, GCC, visual field pattern standard deviation (PSD), and mean deviation (MD). Conclusion The macular OCT-A parameters including wiVD-SL and pfVD-SL were significantly reduced in the eyes with APAC compared the fellow unaffected eyes and normal control eyes. They were correlated well with RNFL, GCC, PSD and MD. The macular vessel density parameters may help monitor the progression of APAC.

scholarly journals Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Harsha L. Rao ◽  
Thanemozhi Srinivasan ◽  
Zia S. Pradhan ◽  
Shruthi Sreenivasaiah ◽  
Dhanaraj A.S. Rao ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Optical Coherence Tomography Angiography ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Optical Coherence ◽  
Visual Field Progression ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

scholarly journals Peripapillary Vessel Density Measurement of Quadrant and Clock-Hour Sectors in Primary Angle Closure Glaucoma Using Optical Coherence Tomography Angiography

2021 ◽  
Author(s):  
YongDong Lin ◽  
ShiRong Chen ◽  
MingZhi Zhang
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Vessel Density ◽  
Angle Closure ◽  
Fiber Layer ◽  
Diagnostic Ability ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Nerve Fiber Layer Thickness

Abstract Background: The purpose of this study was to investigate peripapillary vessel density of primary angle closure glaucoma (PACG) eyes in quadrant and clock-hour sectors, and the diagnostic ability of peripapillary vessel density was also studied.Methods: This was a cross-sectional study on forty-one PACG patients(50 eyes)and twenty-seven healthy subjects(27 eyes). The optic disc was imaged using a 1050-nm-wavelength swept-source optical coherence tomography system (DRI OCT Triton, TOPCON). Peripapillary vessel density was quantified by imageJ software. Characteristics of peripapillary vessel density of quadrant and clock-hour sectors were analyzed, and diagnostic capability was evaluated by areas under the receiver operating characteristics curves (AUCs).Results: Compared to the control group, four quadrants and each clock-hour sectors of peripapillary vessel density of glaucomatous group decreased to different degrees, and vessel density reduced most at 7 o'clock. Except 4 o'clock, there was not any statistical difference between the diagnostic ability of peripapillary vessel density and peripapillary retinal nerve fiber layer thickness. The inferior quadrant peripapillary vessel density had the best diagnostic value (AUCs0.944), followed by 7 o'clock vessel density (AUCs0.937), average vessel density (AUCs0.926) and 7 o'clock RNFL thickness (AUCs0.922).Conclusions: In PACG, the diagnostic ability of peripapillary vessel density is equivalent to peripapillary retinal nerve fiber layer thickness. Understanding spatial characteristics of peripapillary vessel density in PACG may be helpful for clinical diagnosis and treatment.

scholarly journals Comparison of Optical Coherence Tomography Angiography Metrics in Primary Angle-Closure Glaucoma and Normal-Tension Glaucoma

2020 ◽  
Author(s):  
Ruyue Shen ◽  
Yu Wang ◽  
Carol Cheung ◽  
Clement Tham ◽  
Poemen Chan
Keyword(s):  
Optical Coherence Tomography ◽  
Disease Severity ◽  
Optical Coherence Tomography Angiography ◽  
Normal Tension Glaucoma ◽  
Angle Closure ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Primary Angle Closure Glaucoma ◽  
Rnfl Thickness ◽  
Similar Disease

Abstract Purpose: To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A).Methods: One or both eyes of each subjects were imaged for a 3x3mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined.Results: Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369±0.781%) compared with PACG eyes (55.389±0.721%, P=0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis reviewed that, for PACG and NTG eyes, decreased cpVD ([PACG] β=-4.242; CI:-8.120, -0.363 vs [NTG] β=-5.531; CI:-9.472, -1.590) and cpFD ([PACG] β=-8.894;CI:-11.925, -5.864 vs [NTG] β=-12.064; CI:-17.095, -6.932) were associated with decreased RNFL thickness (all P≤0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (Fisher’s Z-test, P=0.045). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (β=-0.707; CI:-1.090, -0.324; P≤0.001) and not associated with the visual field parameters in PACG eyes. Conclusions: Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness. Précis:Optical coherence tomography angiography observed a lower peripapillary microvascular perfusion in early NTG eyes compared with early PACG eyes, despite similar disease severity and retinal nerve fiber layer thickness.

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