Daily tadalafil for the chronic phase of stuttering priapism: a case report

Pleural effusion, as a side effect of tyrosine kinases, may be seen as most commonly associated with dasatinib and very rarely seen with nilotinib. In this report we present a chronic phase of CML case that was treated with nilotinib due to imatinib (Gleevec) allergy and had pleural effusion with nilotinib at 5th year of treatment. If pleural effusion develops in patients taking nilotinib and if this effusion is exudative and lymphocyte predominant, after ruling out pulmonary and cardiac etiologies, it must be associated with nilotinib; according to stage of effusion drug should be discontinued and/or steroid should be started and/or surgery should be performed.

Download Full-text

Efficacy and safety of Bosutinib in Patient with Chronic myeloid leukemia who was intolerant to DASTANIB,NILOTUNIB -Case report

International Journal of Case Reports ◽

10.28933/ijcr-2021-06-1506 ◽

2021 ◽

pp. 225

Author(s):

Keyword(s):

Case Report ◽

Chronic Myeloid Leukemia ◽

Myeloid Leukemia ◽

Kinase Inhibitors ◽

Chronic Phase ◽

Symptomatic Treatment ◽

Molecular Response ◽

Toxicity Profile ◽

Efficacy And Safety ◽

Major Molecular Response

Treatment for Chronic myeloid leukemia has been revolutionized because of availability of different tyrosine kinase inhibitors. Each TKI come with its on toxicity profile as this needs to be taken in account before starting therapy with particular agent in a patient. Most of the adverse effects related to TKI are mild and can be managed by either symptomatic treatment or either by dose reduction. But some patients can become intolerant and to switch to other TKI remains the only option. Bosutinib is currently approved for treatment of chronic phase CML in patients who are either resistant or intolerant to previous TKI. We present a case of 59 year old male patient with CML who was intolerant to Dastanib and Nilotinib but showed excellent hematological and major molecular response to bosutinib

Download Full-text

The simultaneous occurrence of variant hairy cell leukemia and chronic-phase chronic myelogenous leukemia. A case report

Cancer ◽

10.1002/1097-0142(19950415)75:8<2089::aid-cncr2820750810>3.0.co;2-p ◽

1995 ◽

Vol 75 (8) ◽

pp. 2089-2092 ◽

Cited By ~ 10

Author(s):

James E. Reeves ◽

Bruce A. Robbins ◽

Lee R. Pankey ◽

Abdalla L. Elias ◽

William F. Anderson

Keyword(s):

Case Report ◽

Chronic Myelogenous Leukemia ◽

Hairy Cell Leukemia ◽

Chronic Phase ◽

Myelogenous Leukemia ◽

Simultaneous Occurrence ◽

Hairy Cell ◽

Cell Leukemia

Download Full-text

Staged Reconstruction for Acute Charcot's Subtalar Joint Dislocation

Journal of the American Podiatric Medical Association ◽

10.7547/15-088 ◽

2016 ◽

Vol 106 (6) ◽

pp. 445-448 ◽

Cited By ~ 2

Author(s):

Spencer Monaco ◽

Patrick Burns ◽

Alissa Toth

Keyword(s):

Case Report ◽

External Fixation ◽

Limb Salvage ◽

Subtalar Joint ◽

Chronic Phase ◽

Surgical Correction ◽

Conservative Care ◽

Joint Dislocation ◽

Staged Reconstruction

Charcot's neuroarthropathy can have devastating consequences if left untreated or misdiagnosed. With progression of the disease from the acute to the chronic phase, substantial deformity and instability may result, leading to ulceration and a nonfunctional limb. The purpose of this case report is to present a staged reconstruction for active Charcot's neuroarthropathy involving the subtalar joint with complete dislocation that resulted in limb salvage and maintenance of limb function at 1-year follow-up. Although for many patients the mainstay of treatment for early Charcot's neuroarthropathy is conservative care with off-loading, early surgical correction that includes external fixation followed by definitive arthrodesis for select patients may be warranted.

Download Full-text