scholarly journals The effect of using the minimized cardio-pulmonary bypass Systems for Coronary Artery Bypass Grafting in diabetic patients

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Turki B. Albacker ◽  
Mohammed Fouda ◽  
Bakir M. Bakir ◽  
Ahmed Eldemerdash
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Diabetic Patients ◽  
Bypass Grafting ◽  
Perioperative Myocardial Infarction ◽  
Artery Bypass Grafting ◽  
Bypass Group

Abstract Introduction Multiple studies have shown a decrease in the inflammatory response with minimized bypass circuits leading to less complications and mortality rate. On the other hand, some other studies showed that there is no difference in post-operative outcomes. So, the aim of this study is to investigate the clinical benefits of using the Minimized cardiopulmonary Bypass system in Coronary Artery Bypass Grafting and its effect on postoperative morbidity and mortality in diabetic patients as one of the high-risk groups that may benefit from these systems. Methods This is a retrospective study that included 114 diabetic patients who underwent Coronary artery bypass grafting (67 patients with conventional cardiopulmonary bypass system and 47 with Minimized cardiopulmonary bypass system). The patients’ demographics, intra-operative characteristics and postoperative complications were compared between the two groups. Results Coronary artery bypass grafting was done on a beating heart less commonly in the conventional cardiopulmonary bypass group (44.78% vs. 63.83%, p = 0.045). There was no difference between the two groups in blood loss or transfusion requirements. Four patients in the conventional cardiopulmonary bypass group suffered perioperative myocardial infarction while no one had perioperative myocardial infarction in the Minimized cardiopulmonary bypass group. On the other hand, less patients in the conventional group had postoperative Atrial Fibrillation (4.55% vs. 27.5%, p = 0.001). The requirements for Adrenaline and Nor-Adrenaline infusions were more common the conventional group than the Minimized group. Conclusion The use of conventional cardiopulmonary bypass for Coronary Artery Bypass Grafting in diabetic patients was associated with higher use of postoperative vasogenic and inotropic support. However, that did not translate into higher complications rate or mortality.

scholarly journals The Effect of Using the Minimized Cardio-pulmonary Bypass Systems for Coronary Artery Bypass Grafting in Diabetic Patients

2020 ◽  
Author(s):  
Turki Albacker ◽  
Mohammed Fouda ◽  
Bakir M. Bakir ◽  
Ahmed Eldemerdash
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Diabetic Patients ◽  
Bypass Grafting ◽  
Perioperative Myocardial Infarction ◽  
Artery Bypass Grafting ◽  
Bypass Group

Abstract Introduction Multiple studies have shown a decrease in the inflammatory response with minimized bypass circuits leading to less complications and mortality rate. On the other hand, some other studies showed that there is no difference in post-operative outcomes. So, the aim of this study is to investigate the clinical benefits of using the Minimized cardiopulmonary Bypass system in Coronary Artery Bypass Grafting and its effect on postoperative morbidity and mortality in diabetic patients as one of the high-risk groups that may benefit from these systems. Methods: This is a retrospective study that included 114 diabetic patients who underwent Coronary artery bypass grafting (67 patients with conventional cardiopulmonary bypass system and 47 with Minimized cardiopulmonary bypass system). The patients’ demographics, intra-operative characteristics and postoperative complications were compared between the two groups. Results Coronary artery bypass grafting was done on a beating heart less commonly in the conventional cardiopulmonary bypass group (44.78% vs. 63.83%, p = 0.045). There was no difference between the two groups in blood loss or transfusion requirements. Four patients in the conventional cardiopulmonary bypass group suffered perioperative myocardial infarction while no one had perioperative myocardial infarction in the Minimized cardiopulmonary bypass group. On the other hand, less patients in the conventional group had postoperative Atrial Fibrillation (4.55% vs. 27.5%, p = 0.001). The requirements for Adrenaline and Nor-Adrenaline infusions were more common the conventional group than the Minimized group. Conclusion The use of conventional cardiopulmonary bypass for Coronary Artery Bypass Grafting in diabetic patients was associated with higher use of postoperative vasogenic and inotropic support. However, that did not translate into higher complications rate or mortality.

scholarly journals Evaluation of Mortality and Morbidity in Offpump Coronary Artery Bypass Grafting Versus Coronary Artery Bypass Grafting with Cardiopulmonary Bypass in Diabetic Patient Study at NICVD.

2020 ◽  
Vol 13 (1) ◽  
pp. 12-18
Author(s):  
Al Masum Ziaul Haque ◽  
Nasir Uddin Ahmed ◽  
MI Zulkarnine ◽  
Saleh Ahmed
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Diabetic Patients ◽  
Bypass Grafting ◽  
Cardiac Events ◽  
Mortality And Morbidity ◽  
Artery Bypass Grafting

Background: Cardiopulmonary bypass is associated with increased incidence of hyperglycemia. Many studies have shown that diabetes is associated with increased morbidity and mortality in coronary artery bypass (CABG) surgery. We reviewed the outcome of on-pump versus off pump CABG in diabetic patients. Methods- 80 Adult diabetic patients undergoing isolated CABG both on-pump and OPCAB were divided into 2 groups – 40 patients in each group. To evaluate both preoperative, perioperative and postoperative out come and to compare their in hospital outcome mortality and morbidity. Results: Diabetic patients undergoing coronary artery bypass grafting without cardiopulmonary bypass had fewer complications, including neurological dysfunction (7.5% vs. 10.0%, p=0.1), and reduced incidence of prolonged ventilation (7.5% vs. 12.5%, p = 0.709), atrial fibrillation (15.0% vs. 20.0%, p = 0.002), and renal dysfunction (10.0% vs. 17.5%, p=0.556). In postoperative period, 70% patients in OPCAB group did not experience any cardiac events whereas 30% patients developed myocardial infarction, 5% had cardiac arrest and 7.5% had low output syndrome. . In on pump group 65% patients had no cardiac events whereas 35% patients developed one or more cardiac events. Of them 20% patients developed atrial fibrillation, 2.5% developed myocardial infarction, 2.5% develop cardiac arrest and 10% had low output syndrome. 2.5% patient developed both atrial fibrillation and low output. Conclusion: Diabetic patients undergoing CABG without cardiopulmonary bypass compared with those having coronary artery bypass grafting with cardiopulmonary bypass had higher mean predicted mortality and morbidity. Cardiovasc. j. 2020; 13(1): 12-18

scholarly journals Neutrophil-endothelial cells modulation in diabetic patients undergoing coronary artery bypass grafting

1998 ◽  
Vol 14 (4) ◽  
pp. 373-379 ◽  
Author(s):  
Massimo Chello ◽  
Pasquale Mastroroberto ◽  
Francesco Cirillo ◽  
E. Bevacqua ◽  
Antonio Carrano ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Diabetic Patients ◽  
Bypass Grafting ◽  
Artery Bypass Grafting

scholarly journals The Impact of Lung Ventilation on Some Cytokines after Coronary Artery Bypass Grafting

2016 ◽  
Vol 106 (1) ◽  
pp. 87-93 ◽  
Author(s):  
V. Toikkanen ◽  
T. Rinne ◽  
R. Nieminen ◽  
E. Moilanen ◽  
J. Laurikka ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Radial Artery ◽  
Artery Bypass ◽  
Lung Ventilation ◽  
Interleukin 10 ◽  
Bypass Grafting ◽  
Artery Bypass Grafting

Background and Aims: Cardiopulmonary bypass induces a systematic inflammatory response, which is partly understood by investigation of peripheral blood cytokine levels alone; the lungs may interfere with the net cytokine concentration. We investigated whether lung ventilation influences lung passage of some cytokines after coronary artery bypass grafting. Material and Methods: In total, 47 patients undergoing coronary artery bypass grafting were enrolled, and 37 were randomized according to the ventilation technique: (1) No-ventilation group, with intubation tube detached from the ventilator; (2) low tidal volume group, with continuous low tidal volume ventilation; and (3) continuous 10 cm H2O positive airway pressure. Ten selected patients undergoing surgery without cardiopulmonary bypass served as a referral group. Representative pulmonary and radial artery blood samples were collected for the evaluation of calculated lung passage (pulmonary/radial artery) of the pro-inflammatory cytokines (interleukin 6 and interleukin 8) and the anti-inflammatory interleukin 10 immediately after induction of anesthesia (T1), 1 h after restoring ventilation/return of flow in all grafts (T2), and 20 h after restoring ventilation/return of flow in all grafts (T3). Results: Pulmonary/radial artery interleukin 6 and pulmonary/radial artery interleukin 8 ratios ( p = 0.001 and p = 0.05, respectively) decreased, while pulmonary/radial artery interleukin 10 ratio ( p = 0.001) increased in patients without cardiopulmonary bypass as compared with patients with cardiopulmonary bypass. Conclusions: The pulmonary/radial artery equation is an innovative means for the evaluation of cytokine lung passage after coronary artery bypass grafting. The mode of lung ventilation has no impact on some cytokines after coronary artery bypass grafting in patients treated with cardiopulmonary bypass.

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