Tolerability of a new amino acid-based formula for children with IgE-mediated cow’s milk allergy

Abstract Background Amino acid-based formula (AAF) is a relevant dietary strategy for paediatric patients affected by cow’s milk allergy (CMA). The present study was designed to evaluate the hypoallergenicity of a new AAF in children with immunoglobulin (Ig)E-mediated CMA. Methods According to the criteria provided by the American Academy of Pediatrics Subcommittee on Nutrition and Allergic Diseases, we designed a prospective trial in CMA children (aged 1–36 months) aimed to demonstrate the hypoallergenicity of the new AAF in 90% of subjects with 95% confidence during the double-blind, placebo-controlled challenge (DBPCFC). A skin prick test (SPT) with the new AAF was also performed. Results Twenty-nine children [all Caucasian, 55.2% male, mean age (±SD) 16.9 ± 5.7 months] were enrolled. The SPT and the DBPCFC with the new AAF were negative in all study subjects. Conclusions The study results support the hypoallergenicity of the new AAF. This formula could be considered an additional dietary option for non-breastfed children affected by CMA. Trial registration The trial was registered in the ClinicalTrials.gov Protocol Registration System (ID number: NCT03909113).

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Faculty Opinions recommendation of A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1141917.605188 ◽

2009 ◽

Author(s):

Scott Sicherer ◽

Julie Wang

Keyword(s):

Oral Immunotherapy ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Controlled Study ◽

Milk Allergy ◽

Double Blind ◽

Double Blind Placebo ◽

Cow's Milk ◽

Cow's Milk Allergy

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A Randomized, Double-Blind, Placebo-Controlled (DBPC) Study of Milk Oral Immunotherapy (MOIT) for Cow's Milk Allergy (CMA)

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2007.12.545 ◽

2008 ◽

Vol 121 (2) ◽

pp. S137-S137 ◽

Cited By ~ 2

Author(s):

J SKRIPAK ◽

S NASH ◽

N BRERETON ◽

H ROWLEY ◽

S OH ◽

...

Keyword(s):

Oral Immunotherapy ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Double Blind ◽

Double Blind Placebo ◽

Cow's Milk ◽

Cow's Milk Allergy

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A Randomized, Double-Blind, Placebo-Controlled Study of Milk Oral Immunotherapy for Cow's Milk Allergy

PEDIATRICS ◽

10.1542/peds.2009-1870u ◽

2009 ◽

Vol 124 (Supplement 2) ◽

pp. S118.1-S118 ◽

Cited By ~ 1

Author(s):

Sunena Chhabra ◽

Stacie M. Jones

Keyword(s):

Oral Immunotherapy ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Controlled Study ◽

Milk Allergy ◽

Double Blind ◽

Double Blind Placebo ◽

Cow's Milk ◽

Cow's Milk Allergy

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A free amino acid‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey

Immunity Inflammation and Disease ◽

10.1002/iid3.288 ◽

2020 ◽

Vol 8 (1) ◽

pp. 93-105

Author(s):

Joris H. J. Sadelhoff ◽

Astrid Hogenkamp ◽

Selma P. Wiertsema ◽

Lucien F. Harthoorn ◽

Reinilde Loonstra ◽

...

Keyword(s):

Amino Acid ◽

Free Amino Acid ◽

Free Amino ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Cow's Milk ◽

Cow's Milk Allergy

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A Thickened Amino-Acid Formula in Infants with Cow’s Milk Allergy Failing to Respond to Protein Hydrolysate Formulas: A Randomized Double-Blind Trial

Pediatric Drugs ◽

10.1007/s40272-014-0097-x ◽

2014 ◽

Vol 16 (6) ◽

pp. 513-522 ◽

Cited By ~ 10

Author(s):

Christophe Dupont ◽

Nicolas Kalach ◽

Pascale Soulaines ◽

Elena Bradatan ◽

Alain Lachaux ◽

...

Keyword(s):

Amino Acid ◽

Protein Hydrolysate ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Double Blind Trial ◽

Double Blind ◽

Cow's Milk ◽

Blind Trial ◽

Amino Acid Formula

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No difference in symptoms during challenges with homogenized and unhomogenized cow's milk in subjects with subjective hypersensitivity to homogenized milk

Journal of Dairy Research ◽

10.1017/s0022029903006125 ◽

2003 ◽

Vol 70 (2) ◽

pp. 175-179 ◽

Cited By ~ 9

Author(s):

Laura Paajanen ◽

Tuula Tuure ◽

Tuija Poussa ◽

Riitta Korpela

Keyword(s):

Lactose Intolerance ◽

The Other ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Double Blind ◽

Cow's Milk ◽

Cow's Milk Allergy ◽

Ige Mediated

It has been hypothesized that certain consumers tolerate untreated cow's milk, but react to processed (i.e. homogenized and pasteurized) cow's milk although they do not suffer from IgE-mediated cow's milk allergy or lactose intolerance. The aim of the study was to compare the tolerance of unhomogenized and homogenized cow's milk in lactose tolerant adults who had repeatedly experienced better tolerance of unhomogenized than homogenized milk. Forty-four subjects were challenged with homogenized and unhomogenized cow's milk for five days in a randomized, double-blind, cross-over study. No differences in the symptoms during the challenges were found. Roughly half the subjects tolerated the homogenized milk better and the other half tolerated the unhomogenized milk better. The results of this study show no difference in the tolerance of homogenized and unhomogenized milk in adults with self-reported symptoms suggestive of hypersensitivity to homogenized milk.

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