Erythropoietin cerebrospinal concentrations and functional outcomes after a single intravenous infusion of epoetin alfa in patients with malignant extradural spinal cord compression

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 1548-1548 ◽  
Author(s):  
D. A. Loblaw ◽  
L. Holden ◽  
A. Xenocostas ◽  
S. Chander ◽  
P. Cooper ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Intravenous Infusion ◽  
Functional Outcomes ◽  
Cord Compression ◽  
Epoetin Alfa ◽  
Single Intravenous Infusion

Decompressive Surgery for Malignant Spinal Cord Compression (DRAFT)

2018 ◽  
Author(s):  
Esmé Finlay ◽  
Diaa Osman
Keyword(s):  
Spinal Cord ◽  
Radiation Therapy ◽  
Spinal Cord Compression ◽  
Functional Outcomes ◽  
Standard Of Care ◽  
Cord Compression ◽  
Decompressive Surgery ◽  
Functional Quality ◽  
Landmark Study

Metastatic epidural spinal cord compression (MESCC) is a potentially disabling complication associated with advanced cancer. To address whether decompressive surgery followed by radiation therapy is superior to radiation therapy alone, this multi-institutional randomized trial compared outcomes among 101 patients with MESCCC. The study assessed functional outcomes such as ability to ambulate posttreatment, length of ambulation and maintained continence posttreatment, survival time after intervention, and additional functional, quality of life, and medication use outcomes. The practice-changing results of this study indicate that patients who received decompressive surgery and radiation had a longer length of posttreatment ambulation (122 days vs. 13 days, P = 0.03), better overall survival (126 days vs. 100 days, Relative risk 0.60, P = 0.033), lower doses of palliative medications, as well as better performance on several other secondary outcomes. From this landmark study, in appropriately selected patients with MESCC, surgery followed by radiation has become the standard of care.

Spinal cord compression due to extramedullary hematopoiesis in beta-thalassemia

2020 ◽  
Vol 78 (10) ◽  
pp. 663-664
Author(s):  
Renan Ramon Souza LOPES ◽  
Larissa Soares CARDOSO ◽  
Franz ONISHI
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Extramedullary Hematopoiesis ◽  
Cord Compression ◽  
Beta Thalassemia
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