Mitotic Rate and Sentinel Lymph Node Tumor Burden Topography: Integration Into Melanoma Staging and Stratification Use in Clinical Trials

2011 ◽  
Vol 29 (16) ◽  
pp. 2137-2141 ◽  
Author(s):  
Bruce J. Averbook
Keyword(s):  
Clinical Trials ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Mitotic Rate ◽  
Tumor Burden

scholarly journals Long-term prognostic value of sentinel lymph node tumor burden in survival of melanoma patients

2021 ◽  
pp. 1-5
Author(s):  
Mikko Vuoristo ◽  
Timo Muhonen ◽  
Virve Koljonen ◽  
Susanna Juteau ◽  
Micaela Hernberg ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Prognostic Value ◽  
Tumor Burden ◽  
Melanoma Patients

scholarly journals Corrigendum to High Mitotic Rate Predicts Sentinel Lymph Node Involvement in Thin Melanomas

2021 ◽  
Vol 263 ◽  
pp. 289
Author(s):  
Anna J. Skochdopole ◽  
Onur C. Kutlu ◽  
Kathryn E. Engelhardt ◽  
William P. Lancaster ◽  
Andrea M. Abbott ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Mitotic Rate ◽  
Lymph Node Involvement ◽  
Node Involvement

Evaluation of Sentinel Lymph Node Status and its Association with Clinicopathological Factors in Patients with Cutaneous Melanoma: A Retrospective Study

2021 ◽  
Author(s):  
Arash Golpazir ◽  
Mehri Nazeri ◽  
Seyed mostafa meshkati yazd ◽  
Mohamadreza Karoobi ◽  
Houshang Nemati ◽  
...  
Keyword(s):  
Lymph Node ◽  
Retrospective Study ◽  
Sentinel Lymph Node ◽  
Cutaneous Melanoma ◽  
Regional Lymph Node ◽  
Mitotic Rate ◽  
Breslow Thickness ◽  
Lymph Node Status ◽  
Clinicopathological Factors ◽  
Angiolymphatic Invasion

Abstract Background: Cutaneous Melanoma (CM) is cancer with rising prevalence worldwide. The most significant predictor of CM is regional lymph node metastasis. Sentinel Lymph Node (SLN) biopsy has been used to stage CM and to identify lymphatic metastasis. This study aims to evaluate the SLN association with clinicopathological factors in the CM patients for a better surgical management. Methods: This retrospective study included 80 CM patients who had gone through lymphatic mapping and SLN biopsy at Imam Khomeini Hospital in Tehran from 2011 to 2018. The clinical and histologic factors, including sex, age, tumor location, Breslow thickness, ulceration, angiolymphatic invasion, tumor mitotic rate (TMR), and Clark level, were analyzed.Results: Fifty-six patients (70%) were found to have SLN, 19 patients (33.9%) were SLN-positive, and 37 patients (66.1%) were SLN-negative. Breslow thickness was the only variable that was significantly associated with the prediction of SLN. SLN was not correlated with other features such as ulceration, angiolymphatic invasion, and tumor mitotic rate. Complete Lymph Node Dissection (CLND) was carried out in 18 out of 19 SLN-positive patients. Moreover, 5 patients (27.8%) were found to be non-SLN-positive out of 18 SLN biopsy+CLND-positive patients. Furthermore, there was not any significant relationship between the clinicopathological features and the prediction of non-SLN. Conclusions: Breslow thickness was significantly correlated with positive SLN biopsy. Thus, it can be a strong predictor of positive SLN in CM patients.

Tumor-Infiltrating Lymphocyte Grade Is an Independent Predictor of Sentinel Lymph Node Status and Survival in Patients With Cutaneous Melanoma

2012 ◽  
Vol 30 (21) ◽  
pp. 2678-2683 ◽  
Author(s):  
Farhad Azimi ◽  
Richard A. Scolyer ◽  
Pavlina Rumcheva ◽  
Marc Moncrieff ◽  
Rajmohan Murali ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cutaneous Melanoma ◽  
Independent Predictor ◽  
Primary Melanoma ◽  
Mitotic Rate ◽  
Tumor Thickness ◽  
Lymph Node Status ◽  
Inverse Association ◽  
Grade 3

Purpose To determine whether density and distribution of tumor-infiltrating lymphocytes (TILs; TIL grade) is an independent predictor of sentinel lymph node (SLN) status and survival in patients with clinically localized primary cutaneous melanoma. Methods From the Melanoma Institute Australia database, 1,865 patients with a single primary melanoma ≥ 0.75 mm in thickness were identified. The associations of clinical and pathologic factors with SLN status, recurrence-free survival (RFS), and melanoma-specific survival (MSS) were analyzed. Results The majority of patients had either no (TIL grade 0; 35.4%) or few (TIL grade 1; 45.1%) TILs, with a minority showing moderate (TIL grade 2; 16.3%) or marked (TIL grade 3; 3.2%) TILs. Tumor thickness, mitotic rate, and Clark level were inversely correlated with TIL grade (each P < .001). SLN biopsy was performed in 1,138 patients (61.0%) and was positive in 252 (22.1%). There was a significant inverse association between SLN status and TIL grade (SLN positivity rates for each TIL grade: 0, 27.8%; 1, 20.1%; 2, 18.3%; 3, 5.6%; P < .001). Predictors of SLN positivity were decreasing age (P < .001), decreasing TIL grade (P < .001), ulceration (P = .003), increasing tumor thickness (P = .01), satellitosis (P = .03), and increasing mitoses (P = .03). The 5-year MSS and RFS rates were 83% and 76%, respectively (median follow-up, 43 months). Tumor thickness (P < .001), ulceration (P < .001), satellitosis (P < .001), mitotic rate (P = .003), TIL grade (P < .001), and sex (P = .01) were independent predictors of MSS. Patients with TIL grade 3 tumors had 100% survival. Conclusion TIL grade is an independent predictor of survival and SLN status in patients with melanoma. Patients with a pronounced TIL infiltrate have an excellent prognosis.

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