Tumor-Infiltrating Lymphocyte Grade Is an Independent Predictor of Sentinel Lymph Node Status and Survival in Patients With Cutaneous Melanoma

2012 ◽  
Vol 30 (21) ◽  
pp. 2678-2683 ◽  
Author(s):  
Farhad Azimi ◽  
Richard A. Scolyer ◽  
Pavlina Rumcheva ◽  
Marc Moncrieff ◽  
Rajmohan Murali ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cutaneous Melanoma ◽  
Independent Predictor ◽  
Primary Melanoma ◽  
Mitotic Rate ◽  
Tumor Thickness ◽  
Lymph Node Status ◽  
Inverse Association ◽  
Grade 3

Purpose To determine whether density and distribution of tumor-infiltrating lymphocytes (TILs; TIL grade) is an independent predictor of sentinel lymph node (SLN) status and survival in patients with clinically localized primary cutaneous melanoma. Methods From the Melanoma Institute Australia database, 1,865 patients with a single primary melanoma ≥ 0.75 mm in thickness were identified. The associations of clinical and pathologic factors with SLN status, recurrence-free survival (RFS), and melanoma-specific survival (MSS) were analyzed. Results The majority of patients had either no (TIL grade 0; 35.4%) or few (TIL grade 1; 45.1%) TILs, with a minority showing moderate (TIL grade 2; 16.3%) or marked (TIL grade 3; 3.2%) TILs. Tumor thickness, mitotic rate, and Clark level were inversely correlated with TIL grade (each P < .001). SLN biopsy was performed in 1,138 patients (61.0%) and was positive in 252 (22.1%). There was a significant inverse association between SLN status and TIL grade (SLN positivity rates for each TIL grade: 0, 27.8%; 1, 20.1%; 2, 18.3%; 3, 5.6%; P < .001). Predictors of SLN positivity were decreasing age (P < .001), decreasing TIL grade (P < .001), ulceration (P = .003), increasing tumor thickness (P = .01), satellitosis (P = .03), and increasing mitoses (P = .03). The 5-year MSS and RFS rates were 83% and 76%, respectively (median follow-up, 43 months). Tumor thickness (P < .001), ulceration (P < .001), satellitosis (P < .001), mitotic rate (P = .003), TIL grade (P < .001), and sex (P = .01) were independent predictors of MSS. Patients with TIL grade 3 tumors had 100% survival. Conclusion TIL grade is an independent predictor of survival and SLN status in patients with melanoma. Patients with a pronounced TIL infiltrate have an excellent prognosis.

Evaluation of Sentinel Lymph Node Status and its Association with Clinicopathological Factors in Patients with Cutaneous Melanoma: A Retrospective Study

2021 ◽  
Author(s):  
Arash Golpazir ◽  
Mehri Nazeri ◽  
Seyed mostafa meshkati yazd ◽  
Mohamadreza Karoobi ◽  
Houshang Nemati ◽  
...  
Keyword(s):  
Lymph Node ◽  
Retrospective Study ◽  
Sentinel Lymph Node ◽  
Cutaneous Melanoma ◽  
Regional Lymph Node ◽  
Mitotic Rate ◽  
Breslow Thickness ◽  
Lymph Node Status ◽  
Clinicopathological Factors ◽  
Angiolymphatic Invasion

Abstract Background: Cutaneous Melanoma (CM) is cancer with rising prevalence worldwide. The most significant predictor of CM is regional lymph node metastasis. Sentinel Lymph Node (SLN) biopsy has been used to stage CM and to identify lymphatic metastasis. This study aims to evaluate the SLN association with clinicopathological factors in the CM patients for a better surgical management. Methods: This retrospective study included 80 CM patients who had gone through lymphatic mapping and SLN biopsy at Imam Khomeini Hospital in Tehran from 2011 to 2018. The clinical and histologic factors, including sex, age, tumor location, Breslow thickness, ulceration, angiolymphatic invasion, tumor mitotic rate (TMR), and Clark level, were analyzed.Results: Fifty-six patients (70%) were found to have SLN, 19 patients (33.9%) were SLN-positive, and 37 patients (66.1%) were SLN-negative. Breslow thickness was the only variable that was significantly associated with the prediction of SLN. SLN was not correlated with other features such as ulceration, angiolymphatic invasion, and tumor mitotic rate. Complete Lymph Node Dissection (CLND) was carried out in 18 out of 19 SLN-positive patients. Moreover, 5 patients (27.8%) were found to be non-SLN-positive out of 18 SLN biopsy+CLND-positive patients. Furthermore, there was not any significant relationship between the clinicopathological features and the prediction of non-SLN. Conclusions: Breslow thickness was significantly correlated with positive SLN biopsy. Thus, it can be a strong predictor of positive SLN in CM patients.

scholarly journals Association of Histologic Regression in Primary Melanoma With Sentinel Lymph Node Status

2015 ◽  
Vol 151 (12) ◽  
pp. 1301 ◽  
Author(s):  
Simone Ribero ◽  
Maria Rosaria Gualano ◽  
Simona Osella-Abate ◽  
Giacomo Scaioli ◽  
Fabrizio Bert ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Primary Melanoma ◽  
Lymph Node Status ◽  
Node Status ◽  
Sentinel Lymph Node Status

scholarly journals The sentinel lymph node status is an important factor for predicting clinical outcome in patients with Stage I or II cutaneous melanoma

Cancer ◽  
2001 ◽  
Vol 91 (12) ◽  
pp. 2401-2408 ◽  
Author(s):  
Markwin G. Statius Muller ◽  
Paul A. M. van Leeuwen ◽  
Elly S. M de Lange-de Klerk ◽  
Paul J. van Diest ◽  
Rik Pijpers ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Clinical Outcome ◽  
Cutaneous Melanoma ◽  
Stage I ◽  
Lymph Node Status ◽  
Node Status ◽  
Sentinel Lymph Node Status

scholarly journals Sentinel Lymph Node Biopsy in Head and Neck Cutaneous Malignant Melanoma

2019 ◽  
Vol 77 (2) ◽  
pp. 129-133
Author(s):  
Ana Marta António ◽  
Cecília Moura ◽  
Carina Semedo ◽  
Sandra Bitoque ◽  
Mariluz Martins ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Head And Neck ◽  
Cutaneous Melanoma ◽  
Primary Melanoma ◽  
Lymph Node Biopsy ◽  
Superficial Spreading ◽  
Node Biopsy ◽  
Head And Neck Melanoma

Introduction: Sentinel lymph node biopsy (SLNB) is the standard of care for cutaneous melanoma, including head and neck melanoma. The aim of this study was to analyze and characterize SLNB in a population of head and neck melanoma patients. Methods: A unicentric, retrospective study on patients with cutaneous head and neck melanoma who underwent SLNB in the Department of Head and Neck Surgery at the Portuguese Institute of Oncology (IPO) Lisbon between January 2010 and December 2017 was performed. The location of primary melanoma, the identification of SLN, the number of the excised SLN, its lymphatic basin origin and the presence of infraclinic metastasis were analysed. Results:  Ninety-eight patients were eligible to undergo SLNB during the observation period. The most frequent locations of primary melanoma were the scalp (24.5%) and the auricular and periauricular region (23.5%) and the most frequent variants were the superficial spreading melanoma (40.8%) and nodular melanoma (30.6%). SLNB was successfully executed in 78 patients (79.6%). A mean of 3.8 lymph-nodes per patient were excised and in 16.7% SLN were excised in more than one lymphatic basin. The SLN were identified in parotid region (39.8%), level II (29.5%) and level V (18.2%). SLN metastases were detected in 13 patients (16.7%). Conclusion: Surgical approach of head and neck cutaneous melanoma is particularly complex. The redundancy of lymphatic system, the multiple SLN and SLN basins influence the SLNB success and may contribute to high rates of false-negatives with its prognostic implications. All patients should be carefully monitored.  

Primary Cutaneous Melanoma

2018 ◽  
Author(s):  
Clara R Farley ◽  
Keith A Delman ◽  
Michael C Lowe
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Local Excision ◽  
Cutaneous Melanoma ◽  
Wide Local Excision ◽  
Lymph Node Biopsy ◽  
Lymph Node Status ◽  
Primary Cutaneous Melanoma ◽  
Node Biopsy

Melanoma presents a significant health burden as its incidence continues to rise in both sexes and remains the most common cause of skin cancer–related death. Risk factors for the development of melanoma include sun exposure, fair complexion, increasing age, previous melanoma, multiple dysplastic nevi, and familial syndromes. Wide local excision is the standard of care for those with early forms of melanoma, with sentinel lymph node biopsy in appropriate populations. Sentinel lymph node status contributes to the discussion as to whether to pursue completion lymphadenectomy. This review outlines surgical treatment of primary cutaneous melanoma, including wide local excision, sentinel lymph node biopsy, and completion lymphadenectomy.   This review contains 10 figures, 4 tables and 33 references Key words: biopsy, cutaneous, lymphadenectomy, margin, melanoma, pathology, primary, sentinel node, surgery, treatment  

Sign in / Sign up

Export Citation Format

Share Document