Safety and efficacy of single-agent rovalpituzumab tesirine (SC16LD6.5), a delta-like protein 3 (DLL3)-targeted antibody-drug conjugate (ADC) in recurrent or refractory small cell lung cancer (SCLC).

Charles M. Rudin; Maria Catherine Pietanza; Todd Michael Bauer; David R. Spigel; Neal Ready; Daniel Morgensztern; Bonnie S. Glisson; Lauren Averett Byers; Melissa Lynne Johnson; Howard A. Burris; Francisco Robert; Donald K Strickland; Hany Zayed; Ramaswamy Govindan; Scott Dylla; Stanford L. Peng

doi:10.1200/jco.2016.34.15_suppl.lba8505

Safety and efficacy of single-agent rovalpituzumab tesirine (SC16LD6.5), a delta-like protein 3 (DLL3)-targeted antibody-drug conjugate (ADC) in recurrent or refractory small cell lung cancer (SCLC).

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.15_suppl.lba8505 ◽

2016 ◽

Vol 34 (15_suppl) ◽

pp. LBA8505-LBA8505 ◽

Cited By ~ 7

Author(s):

Charles M. Rudin ◽

Maria Catherine Pietanza ◽

Todd Michael Bauer ◽

David R. Spigel ◽

Neal Ready ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Single Agent ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Safety And Efficacy ◽

Drug Conjugate ◽

Antibody Drug

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OA05.03 Single-Agent Rovalpituzumab Tesirine, a Delta-Like Protein 3 (DLL3)-Targeted Antibody-Drug Conjugate (ADC), in Small-Cell Lung Cancer (SCLC)

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2016.11.252 ◽

2017 ◽

Vol 12 (1) ◽

pp. S260-S261

Author(s):

David Spigel ◽

M Catherine Pietanza ◽

Todd Bauer ◽

Neal Ready ◽

Daniel Morgensztern ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Single Agent ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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7LBA Safety, activity, and response durability assessment of single agent rovalpituzumab tesirine, a delta-like protein 3 (DLL3)-targeted antibody drug conjugate (ADC), in small cell lung cancer (SCLC)

European Journal of Cancer ◽

10.1016/s0959-8049(16)31931-1 ◽

2015 ◽

Vol 51 ◽

pp. S712 ◽

Cited By ~ 15

Author(s):

M.C. Pietanza ◽

D. Spigel ◽

T.M. Bauer ◽

N.E. Ready ◽

B.S. Glisson ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Single Agent ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Durability Assessment ◽

Antibody Drug

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A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2019.04.046 ◽

2019 ◽

Vol 513 (4) ◽

pp. 1083-1091 ◽

Cited By ~ 3

Author(s):

Muren Huhe ◽

Jiaxin Lou ◽

Yumeng Zhu ◽

Yu Zhao ◽

Ying Shi ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Anti Tumor Activity ◽

Antibody Drug

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Phase Ia Study of Anti-NaPi2b Antibody–Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non–Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-18-3965 ◽

2019 ◽

Vol 26 (2) ◽

pp. 364-372 ◽

Cited By ~ 3

Author(s):

David E. Gerber ◽

Jeffrey R. Infante ◽

Michael S. Gordon ◽

Sarah B. Goldberg ◽

Miguel Martín ◽

...

Keyword(s):

Lung Cancer ◽

Ovarian Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Platinum Resistant ◽

Antibody Drug

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Rovalpituzumab tesirine. Antibody-drug conjugate targeting delta-like protein 3 (DLL3), Treatment of small cell lung cancer

Drugs of the Future ◽

10.1358/dof.2018.043.04.2781506 ◽

2018 ◽

Vol 43 (4) ◽

pp. 261

Author(s):

J. Gras

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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Faculty Opinions recommendation of Therapy of Small Cell Lung Cancer (SCLC) with a Topoisomerase-I-inhibiting Antibody-Drug Conjugate (ADC) Targeting Trop-2, Sacituzumab Govitecan.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727782010.793565218 ◽

2019 ◽

Author(s):

Scott Kaufmann

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Topoisomerase I ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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Trop-2 as a therapeutic target for the antibody-drug conjugate (ADC), sacituzumab govitecan (IMMU-132), in patients (pts) with previously treated metastatic small-cell lung cancer (mSCLC).

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.15_suppl.8559 ◽

2016 ◽

Vol 34 (15_suppl) ◽

pp. 8559-8559 ◽

Cited By ~ 4

Author(s):

Alexander Starodub ◽

D. Ross Camidge ◽

Ronald J. Scheff ◽

Sajeve Samuel Thomas ◽

Michael J. Guarino ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Therapeutic Target ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Previously Treated ◽

Antibody Drug

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Circulating tumour DNA (ctDNA) analysis in patients (pts) with non-small cell lung cancer (NSCLC) treated with telisotuzumab vedotin (teliso-v), an antibody-drug conjugate targeting c-Met

Annals of Oncology ◽

10.1093/annonc/mdz259.012 ◽

2019 ◽

Vol 30 ◽

pp. v596-v597

Author(s):

R.S. Heist ◽

M. Motwani ◽

L. Naumovski ◽

J. Wu ◽

B.A. Bach ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Ctdna Analysis ◽

Circulating Tumour Dna ◽

Antibody Drug

Download Full-text

MA09.09 First-In-Human Phase 1 Study of ABBV-399, an Antibody-Drug Conjugate (ADC) Targeting C-Met, in Patients with Non-Small Cell Lung Cancer (NSCLC)

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2016.11.449 ◽

2017 ◽

Vol 12 (1) ◽

pp. S395-S396 ◽

Cited By ~ 1

Author(s):

Eric Angevin ◽

John Strickler ◽

Colin Weekes ◽

Rebecca Heist ◽

Daniel Morgensztern ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Phase 1 ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Phase 1 Study ◽

Drug Conjugate ◽

Antibody Drug

Download Full-text

A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope

Cell Reports Medicine ◽

10.1016/j.xcrm.2021.100344 ◽

2021 ◽

Vol 2 (7) ◽

pp. 100344

Author(s):

Swetha Raman ◽

Samantha N. Buongervino ◽

Maria V. Lane ◽

Doncho V. Zhelev ◽

Zhongyu Zhu ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Conformational Epitope ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

Download Full-text