Histological growth pattern as a potential prognostic factor in patients operated for breast cancer liver metastases.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e12576-e12576
Author(s):  
Ali Bohlok ◽  
Lara Botzenhart ◽  
Valerio Lucidi ◽  
Jean Christophe Noel ◽  
Pieter Demetter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver Resection ◽  
Prognostic Factor ◽  
Liver Metastases ◽  
Growth Pattern ◽  
Oncological Outcome ◽  
Consecutive Series ◽  
Significant Prognostic Factor ◽  
International Consensus ◽  
Breast Cancer Liver Metastases

e12576 Background: Indications for surgery in patients with breast cancer liver metastases (BCLM) remain ill-defined. Recently, the histological growth pattern (HGP), such as desmoplastic (dHGP), associated with angiogenesis and inflammation, or replacement (rHGP), associated with vessel co-option and in the absence of immune infiltrate, has been demonstrated as a significant prognostic factor in patients operated for colorectal liver metastases. In BCLM, the distribution and the prognostic value of HGP are poorly documented. We aimed to characterize HGP in a series of patients undergoing liver resection for BCLM and correlate these patterns with postoperative outcomes. Methods: A consecutive series of 58 patients undergoing liver resection for BCLM was reviewed. Clinicopathologic parameters of these patients were analyzed. HGPs were assessed in archival H&E stained tissue sections, according to international consensus guidelines. The proportions of rHGP and dHGP were determined in each metastasis. In case of multiple metastases, mean HGP was calculated for each patient. Patients were categorized as pure (100% rHGP or dHGP) or dominant phenotype ( > 50% rHGP or dHGP, on the entire tumor/normal liver interface). All these factors were correlated with overall and disease-free survivals (OS and DFS). Results: After a mean follow-up of 81 months, 5-years OS and DFS in global population were 49.7% and 22.7%, respectively. No clinicopathologic preoperative factor was found to be predictive for OS or DFS. HGPs were analyzed in a first set of 21 patients. All patients showed some rHGP component. Of these, 11 were pure rHGP (52.4%), 4 dominant-rHGP (19%) and 6 dominant-dHGP (28.6%). Five-years postoperative OS and DFS were of 19.4 and 18.2% in pure rHGP, as compared with 64.8 and 33.3% in patients with some dHGP component (p = 0.089). Conclusions: rHGP appears as the main phenotype of BCLM. First analyzes suggest that surgery for BCLM with pure rHGP is associated with a worse oncological outcome as compared to BCLM with a dHGP component.

The safety and effectiveness of liver resection for breast cancer liver metastases: A systematic review

The Breast ◽  
2016 ◽  
Vol 30 ◽  
pp. 175-184 ◽  
Author(s):  
Katherine Fairhurst ◽  
Lisa Leopardi ◽  
Thomas Satyadas ◽  
Guy Maddern
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Liver Resection ◽  
Liver Metastases ◽  
Breast Cancer Liver Metastases

scholarly journals Chronological occurrence of PI3KCA mutations in breast cancer liver metastases after repeat partial liver resection

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Aldrick Ruiz ◽  
Mylène Sebagh ◽  
Raphaël Saffroy ◽  
Marc-Antoine Allard ◽  
Nelly Bosselut ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver Resection ◽  
Liver Metastases ◽  
Partial Liver Resection ◽  
Breast Cancer Liver Metastases

scholarly journals Prognostic value of histological growth pattern in patients operated for breast cancer liver metastases

2019 ◽  
Vol 30 ◽  
pp. v136
Author(s):  
A. Bohlok ◽  
L. Botzenhart ◽  
V. Lucidi ◽  
J.C. Noël ◽  
P. Demetter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver Metastases ◽  
Growth Pattern ◽  
Prognostic Value ◽  
Breast Cancer Liver Metastases

Histological growth pattern as a potential marker of oligometastatic disease in patients operated for colorectal liver metastases.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15093-e15093
Author(s):  
Ali Bohlok ◽  
Robin Dezes ◽  
Valerio Lucidi ◽  
Fikri Bouazza ◽  
Desislava Germanova ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Growth Pattern ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Surrogate Marker ◽  
Oncological Outcome ◽  
International Consensus ◽  
Dominant Phenotype ◽  
Potential Marker ◽  
Surgical Data

e15093 Background: The identification of oligometastatic profile in patients with resectable colorectal liver metastases (CRLM) would represent a major progress to improve selection for surgery. Currently, in the absence of biomarkers, the most reliable method to identify oligometastatic (OLM) and non-oligometastatic (NOLM) tumors relies on the oncological outcome after metastases-targeted surgery. The histological growth pattern (HGP) of CRLM, defined as desmoplastic (dHGP) or replacement (rHGP), has recently been shown to have prognostic value. We analyzed HGP in a series of patients operated for CRLM, characterized as OLM in case of prolonged postoperative recurrence-free survival (RFS) or NOLM in case of rapid postoperative relapse. Methods: In 357 patients operated for CRLM, we identified OLM patients as those with RFS≥5 years (N = 64), and NOLM patients as those with RFS < 1 year (N = 77). Clinicopathologic and surgical parameters were analyzed. In each CRLM, HGP was assessed in archival H&E stained tissue sections, according to international consensus guidelines. Proportions of rHGP and dHGP were determined in each metastasis. In case of multiple metastases, the mean HGP was calculated in each patient. Patients were categorized as pure (> 95% rHGP or dHGP) or dominant phenotypes (> 50% rHGP or dHGP, of the entire tumor-liver interface). Results: Preoperative characteristics of primary tumor and CRLM, and surgical data were identical in OLM and NOLM groups. In a first set of analyses, HGP was determined in 39 OLM and 52 NOLM patients. Pure dHGP was observed in 54.3% of OLM and 17.3% of NOLM patients (p = 0.001). Pure rHGP was similarly distributed among OLM and NOLM groups. Sixty-nine% of the OLM patients displayed a dHGP-dominant phenotype, whereas 57.7% of the NOLM patients presented with a rHGP-dominant phenotype (p = 0.02). Conclusions: These results confirm the potential prognostic value of HGP in patients operated for CRLM. dHGP, associated with angiogenesis and inflammation, could represent a (surrogate) marker for oligometastatic progression, whereas rHGP appears strongly associated with rapid postoperative relapse.

Liver Resection for Breast Cancer Liver Metastases

2017 ◽  
Vol 265 (4) ◽  
pp. 792-799 ◽  
Author(s):  
Gaya Spolverato ◽  
Alessandro Vitale ◽  
Fabio Bagante ◽  
Roisin Connolly ◽  
Timothy M. Pawlik
Keyword(s):  
Breast Cancer ◽  
Liver Resection ◽  
Liver Metastases ◽  
Breast Cancer Liver Metastases

HOXB9, a gene promoting tumor angiogenesis and proliferation, as a prognostic factor in breast cancer.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 33-33
Author(s):  
H. Seki ◽  
T. Hayashida ◽  
H. Jinno ◽  
S. Hirose ◽  
M. Takahashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Tumor Angiogenesis ◽  
Ductal Carcinoma ◽  
Disease Free Survival ◽  
Specific Cell ◽  
Consecutive Series ◽  
Positive Staining ◽  
Significant Prognostic Factor ◽  
Ki 67

33 Background: We demonstrated that HOXB9, a member of homeobox genes, expression promoted tumor neovascularization and metastasis in vitro and in vivo assay. These findings imply that overexpression of HOXB9 contributes to tumor progression through activation of signaling pathways that alter both tumor-specific cell fates and tumor-stromal microenvironment, leading to increased invasion and metastasis. (Hayashida et al., PNAS 2010) We sought to determine whether these results could be extended to the clinical application. In this study, we evaluated the correlation between HOXB9 expression, clinical outcomes, and the clinicopathological variables in breast cancer patients, and the contribution of HOXB9 expression to tumor cell proliferation and angiogenesis. Methods: A consecutive series of 141 patients with invasive ductal carcinoma who underwent surgical treatment were examined. HOXB9 protein expression was analyzed immunohistochemically using the anti-human HOXB9 polyclonal antibody. Immunostaining of Ki-67, CD31, and CD34 were performed to evaluate the association of proliferation and tumor angiogenesis with HOXB9 expression. Results: Of 141 tumor specimens immunostained for HOXB9, 69 specimens (48.9%) were positive staining. Univariate logistic regression revealed ER and PgR negativity, HER2 positivity, high nuclear grade, and large pathological tumor size as significant variables associated with HOXB9 expression. Moreover, 12 (92.3%) out of 13 triple negative breast cancer showed HOXB9 expression. The disease-free survival (DFS) and the overall survival were significantly different between the HOXB9 positive and negative group; HR=20.714, p=0.001, HR 9.206, p=0.003, respectively. A Multivariate analysis indicated that HOXB9 expression was the only independent prognostic factor for DFS (HR=15.532, p=0.009). In subgroup analysis, HOXB9 positive tumors showed a significant increase in the number of vasculature and the Ki-67 ratio in comparison with HOXB9 negative. Conclusions: Our results suggest that HOXB9 expression promoting the tumor proliferation and the angiogenesis is a significant prognostic factor in breast cancer.

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