Design, Synthesis, and Pharmacological Evaluation of High- Affinity and Selectivity Sigma- 1 and Sigma- 2 Receptor Ligands

Sigma 1

Design, synthesis and pharmacological evaluation of spirocyclic σ1 receptor ligands with exocyclic amino moiety (increased distance 1)

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.04.002 ◽

2011 ◽

Vol 19 (10) ◽

pp. 3141-3151 ◽

Cited By ~ 12

Author(s):

Elisabeth Rack ◽

Roland Fröhlich ◽

Dirk Schepmann ◽

Bernhard Wünsch

Keyword(s):

Receptor Ligands ◽

Design Synthesis ◽

Σ1 Receptor

Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.08.058 ◽

2006 ◽

Vol 14 (3) ◽

pp. 758-775 ◽

Cited By ~ 24

Author(s):

Gabriella Guerrini ◽

Annarella Costanzo ◽

Giovanna Ciciani ◽

Fabrizio Bruni ◽

Silvia Selleri ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Inverse Agonist ◽

Receptor Ligands ◽

Affinity Ligands ◽

Benzodiazepine Receptor Ligands ◽

High Affinity ◽

Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.10.057 ◽

2012 ◽

Vol 22 (24) ◽

pp. 7431-7435 ◽

Cited By ~ 6

Author(s):

Ramakrishna V.S. Nirogi ◽

Rajeshkumar Badange ◽

Ramasastri Kambhampati ◽

Anil Chindhe ◽

Amol D. Deshpande ◽

...

Keyword(s):

Indole Derivatives ◽

Receptor Ligands ◽

Design Synthesis ◽

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.114091 ◽

2022 ◽

pp. 114091

Author(s):

Maria Dichiara ◽

Antonia Artacho-Cordón ◽

Rita Turnaturi ◽

Miriam Santos-Caballero ◽

Rafael González-Cano ◽

...

Keyword(s):

Hydrogen Sulfide ◽

Pain Treatment ◽

Receptor Antagonists ◽

Design Synthesis ◽

Sigma 1 Receptor ◽

Sigma 1 ◽

Treatment Design

Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.3109/14756366.2010.510471 ◽

2011 ◽

Vol 26 (3) ◽

pp. 341-349 ◽

Cited By ~ 4

Author(s):

Ramakrishna V.S. Nirogia ◽

Ramasastri Kambhampati ◽

Anand V. Daulatabad ◽

Parandhama Gudla ◽

Mohammad Shaikh ◽

...

Keyword(s):

Receptor Ligands ◽

Design Synthesis ◽

Conformationally Restricted ◽

Design, Synthesis and Pharmacological Evaluation of 5-Hydroxytryptamine1a Receptor Ligands to Explore the Three-Dimensional Structure of the Receptor

Molecular Pharmacology ◽

10.1124/mol.62.1.15 ◽

2002 ◽

Vol 62 (1) ◽

pp. 15-21 ◽

Cited By ~ 27

Author(s):

Marı́a L. López-Rodrı́guez ◽

Bruno Vicente ◽

Xavier Deupi ◽

Sergio Barrondo ◽

Mireia Olivella ◽

...

Keyword(s):

Three Dimensional ◽

Dimensional Structure ◽

Receptor Ligands ◽

Design Synthesis ◽

Three Dimensional Structure ◽

4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

Chemistry Central Journal ◽

10.1186/s13065-016-0200-1 ◽

2016 ◽

Vol 10 (1) ◽

Cited By ~ 2

Author(s):

Hermia N. Ikome ◽

Fidele Ntie-Kang ◽

Moses N. Ngemenya ◽

Zhude Tu ◽

Robert H. Mach ◽

...

Keyword(s):

Computational Studies ◽

Receptor Ligands ◽

Sigma 1 Receptor ◽

Sigma 1

Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.114038 ◽

2021 ◽

pp. 114038

Author(s):

Francesca S. Abatematteo ◽

Philip D. Mosier ◽

Mauro Niso ◽

Leonardo Brunetti ◽

Francesco Berardi ◽

...

Keyword(s):

Receptor Ligands ◽

Amnesic Effect ◽

High Affinity ◽

Σ1 Receptor ◽

Sigma 1

The pharmacological evaluation of novel and high‐affinity melatonin receptor ligands

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.724.9 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Paula Ann Witt‐Enderby ◽

Justin Julius ◽

Mohamed I Attia ◽

Darius P Zlotos

Keyword(s):

Melatonin Receptor ◽

Receptor Ligands ◽

High Affinity ◽