Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy

High Affinity ◽

Specific high-affinity binding of peripheral benzodiazepine receptor ligands to brain tumors in rat and man

Cancer ◽

10.1002/1097-0142(19900101)65:1<93::aid-cncr2820650120>3.0.co;2-1 ◽

1990 ◽

Vol 65 (1) ◽

pp. 93-97 ◽

Cited By ~ 45

Author(s):

Keith L. Black ◽

Kiyonobu Ikezaki ◽

Emily Santori ◽

Donald P. Becker ◽

Harry V. Vinters

Keyword(s):

Brain Tumors ◽

Benzodiazepine Receptor ◽

Affinity Binding ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

High Affinity Binding ◽

High Affinity

Benzodiazepine Receptor Ligands. 4. Synthesis and Pharmacological Evaluation of 3-Heteroaryl-8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxides

Journal of Medicinal Chemistry ◽

10.1021/jm981126y ◽

1999 ◽

Vol 42 (12) ◽

pp. 2218-2226 ◽

Cited By ~ 27

Author(s):

Annarella Costanzo ◽

Gabriella Guerrini ◽

Giovanna Ciciani ◽

Fabrizio Bruni ◽

Silvia Selleri ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

ChemInform Abstract: Benzodiazepine Receptor Ligands. Synthesis and Preliminary Pharmacological Evaluation of Some 3,7-Disubstituted-4H-(1,2,4)Triazino(3,4-a)phthalazines and 3,7-Disubstituted-4H-(1,2,4)Triazino(3,4-a)phthalazin-4-ones.

ChemInform ◽

10.1002/chin.198938259 ◽

1989 ◽

Vol 20 (38) ◽

Author(s):

E. OCCELLI ◽

G. TARZIA ◽

D. BARONE

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine receptor ligands. Synthesis and pharmacological evaluation of 3-, 7- and 8-substituted [5,1-c][1,2,4]benzotriazines and 5-oxide derivatives. Part I

European Journal of Medicinal Chemistry ◽

10.1016/0223-5234(96)80363-1 ◽

1996 ◽

Vol 31 (4) ◽

pp. 259-272 ◽

Cited By ~ 14

Author(s):

G Guerrini ◽

A Costanzo ◽

F Bruni ◽

S Selleri ◽

L Casilli ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

Journal of Medicinal Chemistry ◽

10.1021/jm031020p ◽

2004 ◽

Vol 47 (7) ◽

pp. 1807-1822 ◽

Cited By ~ 99

Author(s):

Robert W. Carling ◽

Kevin W. Moore ◽

Leslie J. Street ◽

Deborah Wild ◽

Catherine Isted ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Aminobutyric Acid ◽

Receptor Ligands ◽

Binding Selectivity ◽

High Affinity

High affinity central benzodiazepine receptor ligands. Part 2: quantitative structure–activity relationships and comparative molecular field analysis of pyrazolo[4,3- c ]quinolin-3-ones

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00262-5 ◽

2001 ◽

Vol 9 (2) ◽

pp. 431-444 ◽

Cited By ~ 18

Author(s):

L. Savini ◽

L. Chiasserini ◽

C. Pellerano ◽

G. Biggio ◽

E. Maciocco ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Field Analysis ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Receptor Ligands ◽

Quantitative Structure Activity Relationships

High Affinity ◽

Structure Activity ◽

Central Benzodiazepine Receptor ◽

ChemInform Abstract: Synthesis of Substituted 7,12-Dihydropyrido(3,2-b:5,4-b′)diindoles: Rigid Planar Benzodiazepine Receptor Ligands with Inverse Agonist/ Antagonist Properties.

ChemInform ◽

10.1002/chin.199108210 ◽

2010 ◽

Vol 22 (8) ◽

pp. no-no

Author(s):

M. L. TRUDELL ◽

S. L. LIFER ◽

Y.-C. TAN ◽

M. J. MARTIN ◽

L. DENG ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Inverse Agonist ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

Benzodiazepine Receptor Ligands. 7. Synthesis and Pharmacological Evaluation of New 3-Esters of the 8-Chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) Derivative: An Anxioselective Agent in Rodents

Journal of Medicinal Chemistry ◽

10.1021/jm020944u ◽

2002 ◽

Vol 45 (26) ◽

pp. 5710-5720 ◽

Cited By ~ 16

Author(s):

Annarella Costanzo ◽

Gabriella Guerrini ◽

Giovanna Ciciani ◽

Fabrizio Bruni ◽

Camilla Costagli ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

High-affinity benzodiazepine receptor ligands among benzodiazepines and betacarbolines with different intrinsic activity

International Journal of Quantum Chemistry ◽

10.1002/qua.560360721 ◽

2009 ◽

Vol 36 (S16) ◽

pp. 273-280

Author(s):

A. Yliniemelä ◽

J. Gynther ◽

H. Konschin ◽

H. Tylli ◽

J. Rouvinen

Keyword(s):

Benzodiazepine Receptor ◽

Intrinsic Activity ◽

Receptor Ligands ◽

High Affinity

ChemInform Abstract: Benzodiazepine Receptor Ligands. Synthesis and Pharmacological Evaluation of 6-Aryl-3,8-disubstituted-1,2,4-triazolo(3,4-a)phthalazines.

ChemInform ◽

10.1002/chin.198923193 ◽

1989 ◽

Vol 20 (23) ◽

Author(s):

G. TARZIA ◽

E. OCCELLI ◽

D. BARONE

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽