Considerations for Applying Physiologically Based Pharmacokinetic Models in Risk Assessment

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-6 ◽

2016 ◽

pp. 123-139 ◽

Author(s):

Chadwick Thompson ◽

Babasaheb Sonawane ◽

Andy Nong ◽

Kannan Krishnan

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Pesticide Exposures ◽

Physiologically Based

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Risk assessment for drug degradation products using physiologically-based pharmacokinetic models

10.17077/etd.lw22xk3x ◽

2014 ◽

Author(s):

Quynh Hoa Nguyen

Keyword(s):

Risk Assessment ◽

Degradation Products ◽

Pharmacokinetic Models ◽

Drug Degradation ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Models in the Risk Assessment of Developmental Neurotoxicants

Handbook of Developmental Neurotoxicology ◽

10.1016/b978-0-12-809405-1.00047-x ◽

2018 ◽

pp. 539-557

Author(s):

Kannan Krishnan

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Framework for Evaluation of Physiologically‐Based Pharmacokinetic Models for Use in Safety or Risk Assessment

Risk Analysis ◽

10.1111/j.0272-4332.2004.00561.x ◽

2004 ◽

Vol 24 (6) ◽

pp. 1697-1717 ◽

Author(s):

Leona H. Clark ◽

R. Woodrow Setzer ◽

Hugh A. Barton

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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An introduction to the use of physiologically based pharmacokinetic models in risk assessment

Statistical Methods in Medical Research ◽

10.1191/096228097667166302 ◽

1997 ◽

Vol 6 (4) ◽

pp. 341-358 ◽

Author(s):

A. Bailer ◽

D. Dankovic

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Approaches for Applications of Physiologically Based Pharmacokinetic Models in Risk Assessment

Journal of Toxicology and Environmental Health Part B ◽

10.1080/10937400701724337 ◽

2008 ◽

Vol 11 (7) ◽

pp. 519-547 ◽

Author(s):

Chad M. Thompson ◽

Babasaheb Sonawane ◽

Hugh A. Barton ◽

Robert S. DeWoskin ◽

John C. Lipscomb ◽

...

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Models: Applications in Carcinogenic Risk Assessment

New Trends in Pharmacokinetics ◽

10.1007/978-1-4684-8053-5_20 ◽

1991 ◽

pp. 355-390 ◽

Author(s):

D. Krewski ◽

J. R. Withey ◽

L. F. Ku ◽

C. C. Travis

Keyword(s):

Risk Assessment ◽

Carcinogenic Risk ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Carcinogenic Risk Assessment

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Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2013.03.005 ◽

2013 ◽

Vol 66 (1) ◽

pp. 116-129 ◽

Author(s):

M.E. (Bette) Meek ◽

Hugh A. Barton ◽

Jos G. Bessems ◽

John C. Lipscomb ◽

Kannan Krishnan

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models

Drug Metabolism and Disposition ◽

10.1124/dmd.119.089599 ◽

2020 ◽

Vol 48 (4) ◽

pp. 288-296 ◽

Author(s):

Makiko Yamada ◽

Shin-ichi Inoue ◽

Daisuke Sugiyama ◽

Yumi Nishiya ◽

Tomoko Ishizuka ◽

...

Keyword(s):

Risk Assessment ◽

Drug Interactions ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Symbolic Solutions of Small Linear Physiologically Based Pharmacokinetic Models Useful in Risk Assessment and Experimental Design

ACS Symposium Series - Biomarkers for Agrochemicals and Toxic Substances ◽

10.1021/bk-1996-0643.ch018 ◽

1996 ◽

pp. 242-255

Author(s):

Robert N. Brown

Keyword(s):

Risk Assessment ◽

Experimental Design ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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