Toxicokinetics and Risk Assessment
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In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Empirically Observed Distributions of Pharmacokinetic and Pharmacodynamic Variability in Humans—Implications for the Derivation of Single-Point Component Uncertainty Factors Providing Equivalent Protection as Existing Reference Doses

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-4 ◽

2016 ◽

pp. 69-93 ◽

Cited By ~ 2

Author(s):

Dale Hattis ◽

Meghan Keaney Lynch

Keyword(s):

Single Point ◽

Uncertainty Factors ◽

Reference Doses

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In Silico Predictions of Partition Coefficients for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-8 ◽

2016 ◽

pp. 141-183

Author(s):

Kannan Krishnan ◽

Andy Nong ◽

Sami Haddad

Keyword(s):

In Silico ◽

Partition Coefficients ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Silico Predictions

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Considerations of Design and Data When Developing Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-7 ◽

2016 ◽

pp. 141-166

Author(s):

Peter J. Robinson ◽

Jeffery M. Gearhart ◽

Deirdre A. Mahle ◽

Elaine A. Merrill ◽

Teresa R. Sterner ◽

...

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Considerations for Applying Physiologically Based Pharmacokinetic Models in Risk Assessment

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-6 ◽

2016 ◽

pp. 123-139 ◽

Cited By ~ 1

Author(s):

Chadwick Thompson ◽

Babasaheb Sonawane ◽

Andy Nong ◽

Kannan Krishnan

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Derivation and Modeling of Mechanistic Data for Use in Risk Assessment

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-3 ◽

2016 ◽

pp. 47-68

Author(s):

Ronald L. Melnick

Keyword(s):

Risk Assessment

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Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-15 ◽

2016 ◽

pp. 301-348

Author(s):

Robert S. DeWoskin ◽

John C. Lipscomb ◽

Chadwick Thompson ◽

Weihsueh A. Chiu ◽

Paul Schlosser ◽

...

Keyword(s):

Information System ◽

Risk Information ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Integrated Risk ◽

Physiologically Based

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Use of Classical Pharmacokinetic Evaluations in Drug Development and Safety Assessment

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-5 ◽

2016 ◽

pp. 95-122

Author(s):

Rakesh Dixit ◽

Peter Ward

Keyword(s):

Drug Development ◽

Safety Assessment

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Guidance for the Development of Chemical-Specific Adjustment Factors: Integration with Mode of Action Frameworks

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-2 ◽

2016 ◽

pp. 27-46

Author(s):

Bette Meek ◽

Andrew Renwick

Keyword(s):

Mode Of Action ◽

Adjustment Factors

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Statistical Issues in Physiologically Based Pharmacokinetic Modeling

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-13 ◽

2016 ◽

pp. 269-283

Author(s):

Weihsueh A. Chiu

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Statistical Issues

Download Full-text

Toxicokinetics and Risk AssessmentLatest Publications

TOTAL DOCUMENTS

H-INDEX

Published By CRC Press

In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Empirically Observed Distributions of Pharmacokinetic and Pharmacodynamic Variability in Humans—Implications for the Derivation of Single-Point Component Uncertainty Factors Providing Equivalent Protection as Existing Reference Doses

In Silico Predictions of Partition Coefficients for Physiologically Based Pharmacokinetic Models

Considerations of Design and Data When Developing Physiologically Based Pharmacokinetic Models

Considerations for Applying Physiologically Based Pharmacokinetic Models in Risk Assessment

Derivation and Modeling of Mechanistic Data for Use in Risk Assessment

Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Use of Classical Pharmacokinetic Evaluations in Drug Development and Safety Assessment

Guidance for the Development of Chemical-Specific Adjustment Factors: Integration with Mode of Action Frameworks

Statistical Issues in Physiologically Based Pharmacokinetic Modeling

Toxicokinetics and Risk Assessment
Latest Publications