Toxicokinetics and Risk Assessment
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15

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1

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Published By CRC Press

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Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords

In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Empirically Observed Distributions of Pharmacokinetic and Pharmacodynamic Variability in Humans—Implications for the Derivation of Single-Point Component Uncertainty Factors Providing Equivalent Protection as Existing Reference Doses

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-4 ◽

2016 ◽

pp. 69-93 ◽

Author(s):

Dale Hattis ◽

Meghan Keaney Lynch

Keyword(s):

Single Point ◽

Uncertainty Factors ◽

Reference Doses

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In Silico Predictions of Partition Coefficients for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-8 ◽

2016 ◽

pp. 141-183

Author(s):

Kannan Krishnan ◽

Andy Nong ◽

Sami Haddad

Keyword(s):

In Silico ◽

Partition Coefficients ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Silico Predictions

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Considerations of Design and Data When Developing Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-7 ◽

2016 ◽

pp. 141-166

Author(s):

Peter J. Robinson ◽

Jeffery M. Gearhart ◽

Deirdre A. Mahle ◽

Elaine A. Merrill ◽

Teresa R. Sterner ◽

...

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Considerations for Applying Physiologically Based Pharmacokinetic Models in Risk Assessment

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-6 ◽

2016 ◽

pp. 123-139 ◽

Author(s):

Chadwick Thompson ◽

Babasaheb Sonawane ◽

Andy Nong ◽

Kannan Krishnan

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Derivation and Modeling of Mechanistic Data for Use in Risk Assessment

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-3 ◽

2016 ◽

pp. 47-68

Author(s):

Ronald L. Melnick

Keyword(s):

Risk Assessment

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Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-15 ◽

2016 ◽

pp. 301-348

Author(s):

Robert S. DeWoskin ◽

John C. Lipscomb ◽

Chadwick Thompson ◽

Weihsueh A. Chiu ◽

Paul Schlosser ◽

...

Keyword(s):

Information System ◽

Risk Information ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Integrated Risk ◽

Physiologically Based

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Use of Classical Pharmacokinetic Evaluations in Drug Development and Safety Assessment

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-5 ◽

2016 ◽

pp. 95-122

Author(s):

Rakesh Dixit ◽

Peter Ward

Keyword(s):

Drug Development ◽

Safety Assessment

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Guidance for the Development of Chemical-Specific Adjustment Factors: Integration with Mode of Action Frameworks

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-2 ◽

2016 ◽

pp. 27-46

Author(s):

Bette Meek ◽

Andrew Renwick

Keyword(s):

Mode Of Action ◽

Adjustment Factors

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Statistical Issues in Physiologically Based Pharmacokinetic Modeling

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-13 ◽

2016 ◽

pp. 269-283

Author(s):

Weihsueh A. Chiu

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Statistical Issues

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