scholarly journals Reduced Ovulation Rate in Adolescent Girls Born Small for Gestational Age

2002 ◽  
Vol 87 (7) ◽  
pp. 3391-3393 ◽  
Author(s):  
Lourdes Ibáñez ◽  
Neus Potau ◽  
Angela Ferrer ◽  
Francisco Rodriguez-Hierro ◽  
Maria Victoria Marcos ◽  
...  
2020 ◽  
Vol 33 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Indre Petraitiene ◽  
Margarita Valuniene ◽  
Kristina Jariene ◽  
Audrone Seibokaite ◽  
Kerstin Albertsson-Wikland ◽  
...  

1999 ◽  
Vol 84 (12) ◽  
pp. 4739-4741 ◽  
Author(s):  
Lourdes Ibáñez ◽  
Neus Potau ◽  
Maria Victoria Marcos ◽  
Francis de Zegher

2000 ◽  
Vol 47 (5) ◽  
pp. 575-577 ◽  
Author(s):  
Lourdes Ibáñez ◽  
Neus Potau ◽  
Goya Enriquez ◽  
Francis De Zegher

2000 ◽  
Vol 85 (7) ◽  
pp. 2624-2626 ◽  
Author(s):  
Lourdes Ibáñez ◽  
Neus Potau ◽  
Francis de Zegher

Girls with reduced prenatal growth are known to have, at birth, a small ovarian fraction of primordial follicles and, in adolescence, a uterus and ovaries of small size. We have now examined whether reduced prenatal growth is also followed by changes in the relationships among FSH, inhibin B and estradiol in adolescent girls. We studied 48 post-menarcheal girls (age 13.6 ± 1.4 yr) who were either born with an appropriate weight for gestational age (AGA; n = 33; mean weight 3.3 Kg) or born small for gestational age (SGA; n = 15; mean weight 2.4 Kg). Serum FSH, inhibin B and estradiol concentrations were measured in the early follicular phase (range: day 5 ± 3). SGA girls had, compared to AGA girls, elevated serum FSH (7.2 ± 0.7 vs 4.5 ± 0.3 IU/mL; p = 0.0002), similar inhibin B (62.1 ± 8.1 vs 60.7 ± 6.5 pg/mL) and lower estradiol concentrations (12.1 ± 1.5 vs 21.2 ± 2.4 pg/mL; p = 0.02). SGA girls thus displayed, early after menarche, a pattern that points to hyporesponsiveness of the ovarian granulosa cell fraction and that is reminiscent of reproductive aging. In conclusion, the gynecological correlates of prenatal growth restriction are herewith extended to include ovarian hyporesponsiveness to FSH in adolescence.


Sign in / Sign up

Export Citation Format

Share Document