Anovulation in Eumenorrheic, Nonobese Adolescent Girls Born Small for Gestational Age: Insulin Sensitization Induces Ovulation, Increases Lean Body Mass, and Reduces Abdominal Fat Excess, Dyslipidemia, and Subclinical Hyperandrogenism

2003 ◽  
Vol 58 (5) ◽  
pp. 319-320 ◽  
Author(s):  
Lourdes Ibáñez ◽  
Neus Potau ◽  
Angela Ferrer ◽  
Francisco Rodriguez-Hierro ◽  
Maria Victoria Marcos ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Adolescent Girls ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Abdominal Fat

scholarly journals Randomized GH trial with two different dosages in combination with a GnRH analogue in short small for gestational age children: effects on metabolic profile and serum GH, IGF1, and IGFBP3 levels

2010 ◽  
Vol 162 (5) ◽  
pp. 887-895 ◽  
Author(s):  
Daniëlle van der Kaay ◽  
Boudewijn Bakker ◽  
Flip van der Hulst ◽  
Dick Mul ◽  
Jaap Mulder ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Metabolic Profile ◽  
Combined Treatment ◽  
Medical Attention ◽  
Gnrh Analogue ◽  
Group B

BackgroundGnRH analogue (GnRHa) combined with GH treatment has been proposed to increase adult height. Effect on metabolic profile and GH, IGF1, and IGFBP3 levels in short small for gestational age (SGA) children is unknown.ObjectiveTo assess fat mass and lean body mass SDS, percentage trunk fat, blood pressure (BP), insulin sensitivity (Si), β-cell function (disposition index, DI), lipid profile, and GH, IGF1, and IGFBP3 levels during 2 years of combined treatment.SubjectsForty-one pubertal short SGA children with a mean (±s.d.) age of 12.1 (±1.0) years.DesignChildren received 3.75 mg of leuprolide acetate depot subcutaneously every 4 weeks, and they were randomly assigned to receive 1 mg (group A) or 2 mg (group B) of GH/m2per day.ResultsPercentage trunk fat increased in both groups, but to a lower extent in group B. Lean body mass SDS increased only in group B. Changes in BP, Si, DI, and lipids were similar in both groups. Si significantly decreased, but DI remained unchanged. Lipids remained normal. GH and IGF1 levels were significantly higher in group B.ConclusionOur study is the first to report that 2 years of combined treatment with a GnRHa and either 1 or 2 mg GH/m2per day does not adversely affect body composition and metabolic profile of short SGA children who come under medical attention at the onset of puberty. There was a dose-dependent effect on fat mass SDSheight, percentage trunk fat, lean body mass SDSheight, and GH and IGF1 levels in favor of treatment with GnRHa and the higher GH dose of 2 mg/m2per day.

scholarly journals Reduced Ovulation Rate in Adolescent Girls Born Small for Gestational Age

2002 ◽  
Vol 87 (7) ◽  
pp. 3391-3393 ◽  
Author(s):  
Lourdes Ibáñez ◽  
Neus Potau ◽  
Angela Ferrer ◽  
Francisco Rodriguez-Hierro ◽  
Maria Victoria Marcos ◽  
...  
Keyword(s):  
Adolescent Girls ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Ovulation Rate

Body Mass Index Change Between Pregnancies and Small for Gestational Age Births

2004 ◽  
Vol 104 (2) ◽  
pp. 286-292 ◽  
Author(s):  
Christine J. Cheng ◽  
Kerry Bommarito ◽  
Akihiko Noguchi ◽  
William Holcomb ◽  
Terry Leet
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Body Mass Index Change ◽  
Index Change

scholarly journals Arterial health during early childhood following abnormal fetal growth

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Rasmus F.W. Olander ◽  
Johnny K.M. Sundholm ◽  
Sanna Suonsyrjä ◽  
Taisto Sarkola
Keyword(s):  
Blood Pressure ◽  
Early Childhood ◽  
Cardiovascular Risk ◽  
Lean Body Mass ◽  
Body Mass ◽  
Fetal Growth ◽  
Gestational Age ◽  
Fetal Programming ◽  
Independent Effect ◽  
Appropriate For Gestational Age

Abstract Background Abnormal fetal growth is associated with increased cardiovascular risk in adulthood. We investigated the effect of fetal programming on arterial health and morphology during early childhood. Methods We examined 90 children (median age 5.81 years, interquartile range: 5.67; 5.95), born small for gestational age with fetal growth restriction, large or appropriate for gestational age (SGA, N = 23, LGA, N = 19, AGA N = 48). We measured body composition, anthropometrics, blood pressure, pulse wave velocity (PWV), lipids, glucose and inflammatory markers, and assessed carotid, brachial, radial and femoral arterial morphology and stiffness using very-high resolution ultrasound (46–71 MHz). Results LGA showed increased anthropometry, lean body mass and body mass index. SGA displayed decreased anthropometry and lean body mass. Blood pressure, PWV, carotid artery stiffness and blood work did not differ groupwise. Differences in lumen diameters, intima-media thicknesses (IMT) and adventitia thicknesses disappeared when adjusted for lean body mass and sex. In multiple regression models arterial dimensions were mainly predicted by lean body mass, with birth weight remaining associated only with carotid and brachial lumen dimensions, and not with IMTs. Carotid-femoral PWV was predicted by height and blood pressure only. No independent effect of adiposity was observed. Conclusions Arterial dimensions in childhood associate with current anthropometrics, especially lean body mass, and sex, explaining differences in arterial layer thickness. We found no signs of fetal programming of cardiovascular risk or arterial health in early childhood.

scholarly journals Sex Hormones, Gonad Size, and Metabolic Profile in Adolescent Girls Born Small for Gestational Age with Catch-up Growth

2020 ◽  
Vol 33 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Indre Petraitiene ◽  
Margarita Valuniene ◽  
Kristina Jariene ◽  
Audrone Seibokaite ◽  
Kerstin Albertsson-Wikland ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Adolescent Girls ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Metabolic Profile ◽  
Gonad Size ◽  
Catch Up
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