scholarly journals Spectrum of transcriptional, dimerization, and dominant negative properties of twenty different mutant thyroid hormone beta-receptors in thyroid hormone resistance syndrome.

1994 ◽  
Vol 8 (9) ◽  
pp. 1262-1277
Author(s):  
T N Collingwood ◽  
M Adams ◽  
Y Tone ◽  
V K Chatterjee
Keyword(s):  
Thyroid Hormone ◽  
Dominant Negative ◽  
Hormone Resistance ◽  
Thyroid Hormone Resistance ◽  
Beta Receptors ◽  
Thyroid Hormone Resistance Syndrome

Transcriptional repression by nuclear receptors: mechanisms and role in disease

2000 ◽  
Vol 28 (4) ◽  
pp. 390-396 ◽  
Author(s):  
J. D. Love ◽  
J. T. Gooch ◽  
L. Nagy ◽  
V. K. K. Chatterjee ◽  
J. W. R. Schwabe
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Hormone ◽  
Ligand Binding ◽  
Nuclear Receptors ◽  
Transcriptional Repression ◽  
Dominant Negative ◽  
Receptor Interaction ◽  
Hormone Resistance ◽  
Thyroid Hormone Resistance ◽  
Repressor Proteins

Co-repressor proteins mediate transcriptional repression by nuclear receptors in the absence of ligand. The identification of a co-repressor-receptor interaction motif, and the finding that compressors and co-activators compete for the same site on the receptor, suggests a simple mechanism for the switch from repression to activation upon ligand binding. Defects in this mechanism result in dominant-negative receptors that repress transcription. Such receptors have been implicated in several clinically important diseases, including thyroid hormone resistance and diabetes mellitus.

Thyroid hormone resistance syndrome – own experiences

2017 ◽  
Vol 23 (4) ◽  
pp. 209-214
Author(s):  
Tomasz Jackowski ◽  
◽  
Elżbieta Petriczko ◽  
Anita Horodnicka-Józwa ◽  
Mieczysław Walczak ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Resistance ◽  
Thyroid Hormone Resistance ◽  
Thyroid Hormone Resistance Syndrome

Marked Hyperthyroxinemia During Amiodarone Treatment Revealing Thyroid Hormone Resistance Syndrome

Thyroid ◽  
2008 ◽  
Vol 18 (9) ◽  
pp. 1019-1020 ◽  
Author(s):  
Bernard Goichot ◽  
Frédérique Savagner ◽  
Rémy Sapin ◽  
Florina Luca ◽  
Jean-Louis Schlienger
Keyword(s):  
Thyroid Hormone ◽  
Hormone Resistance ◽  
Thyroid Hormone Resistance ◽  
Amiodarone Treatment ◽  
Thyroid Hormone Resistance Syndrome
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