Aspirin combined with high-dose PPIs reduces cancer risk in Barrett’s oesophagus, research shows

2018 ◽  
Keyword(s):  
Cancer Risk ◽  
Barrett’S Oesophagus ◽  
High Dose ◽  
Barrett's Oesophagus

scholarly journals Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders

2020 ◽  
Vol 7 (1) ◽  
pp. e000357
Author(s):  
James Britton ◽  
Paraskevi Taxiarchi ◽  
Glen Martin ◽  
Robert Willert ◽  
Maria Horne ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Symptom Control ◽  
Rank Correlation ◽  
Colonic Polyps ◽  
Colonic Polyp ◽  
Barrett’S Oesophagus ◽  
Cancer Worry ◽  
Barrett's Oesophagus ◽  
Acid Regurgitation ◽  
Spearman’S Rank Correlation

ObjectiveTo assess health-related quality of life in patients with non-dysplastic Barrett’s oesophagus (NDBO) and endoscopically treated dysplastic Barrett’s oesophagus (DBO).DesignThis quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from three other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance and healthy individuals. Fisher’s exact and Spearman’s rank correlation tests were used for analysis. Propensity score matching adjusted for age, sex and comorbidities.Results687 participants were eligible for analysis (NDBO n=306, DBO n=49, GORD n=132, colonic polyps n=152 and healthy n=48). 53% of NDBO participants reported similarly high cancer worry, comparable to DBO (50%, p=0.933) and colonic polyp participants (51%, p=0.355). Less cancer worry was reported in GORD participants (43.4%, p=0.01 vs NDBO). NDBO participants reported anxiety in 15.8% and depression in 8.6% of cases, which was similar to the other disease cohorts. Moderate or severe heartburn or acid regurgitation was found in 11% and 10%, respectively, in the NDBO cohort, comparable to DBO participants (heartburn 2% p=0.172, acid regurgitation 4% p=0.31) but lower (better) than GORD participants (heartburn 31% p=<0.001, acid regurgitation 25% p=0.001). NDBO participants with moderate or severe GORD symptoms were associated with higher rates of anxiety (p=<0.001), depression (p=<0.001) and cancer worry (p=<0.001). NDBO patients appropriately perceiving their cancer risk as low had lower rates of cancer worry (p=<0.001).ConclusionThis study provides insight into the problems Barrett’s oesophagus patients may face. Future care pathways must be more patient focussed to address misconceptions of cancer risk, oesophageal cancer related worry and GORD symptom control.

scholarly journals Barrett's oesophagus: epidemiology, cancer risk and implications for management

Gut ◽  
2013 ◽  
Vol 63 (1) ◽  
pp. 191-202 ◽  
Author(s):  
Pieter Jan F de Jonge ◽  
Mark van Blankenstein ◽  
William M Grady ◽  
Ernst J Kuipers
Keyword(s):  
Cancer Risk ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

scholarly journals The effects of high-dose esomeprazole on gastric and oesophageal acid exposure and molecular markers in Barrett’s oesophagus

2010 ◽  
Vol 32 (8) ◽  
pp. 1023-1030 ◽  
Author(s):  
A. Abu-Sneineh ◽  
W. Tam ◽  
M. Schoeman ◽  
R. Fraser ◽  
A. R. Ruszkiewicz ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Acid Exposure ◽  
Barrett’S Oesophagus ◽  
High Dose ◽  
Barrett's Oesophagus

Length of Barrett's oesophagus and cancer risk: implications from a large sample of patients with early oesophageal adenocarcinoma

Gut ◽  
2015 ◽  
Vol 65 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Heiko Pohl ◽  
Oliver Pech ◽  
Haris Arash ◽  
Manfred Stolte ◽  
Hendrik Manner ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Large Sample ◽  
Barrett's Oesophagus

Barrett's oesophagus: Intestinal metaplasia is not essential for cancer risk

2007 ◽  
Vol 42 (11) ◽  
pp. 1271-1274 ◽  
Author(s):  
Clive J. Kelty ◽  
Martin D. Gough ◽  
Quintin Van Wyk ◽  
Timothy J. Stephenson ◽  
Roger Ackroyd
Keyword(s):  
Cancer Risk ◽  
Intestinal Metaplasia ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

scholarly journals OC-027 Defining Cancer Risk in Barrett’S Oesophagus using a 90-Gene Signature

Gut ◽  
2013 ◽  
Vol 62 (Suppl 1) ◽  
pp. A12.1-A12
Author(s):  
S Varghese ◽  
R Newton ◽  
C S Ross-Innes ◽  
K K Krishnadath ◽  
P Lao-Sirieix ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Gene Signature ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

scholarly journals PTU-172 Oesophageal cancer risk: results of a prospective cohort with Barrett's oesophagus

Gut ◽  
2012 ◽  
Vol 61 (Suppl 2) ◽  
pp. A255.1-A255
Author(s):  
B T Theron ◽  
H Padmanabhan ◽  
H Aladin ◽  
B T Cooper ◽  
N Trudgill
Keyword(s):  
Cancer Risk ◽  
Oesophageal Cancer ◽  
Prospective Cohort ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus
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