colonic polyp
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2021 ◽  
Author(s):  
Kittipot Uppakarn ◽  
Khotchawan Bangpanwimon ◽  
Tipparat Hongpattarakere ◽  
Worrawit Wanitsuwan

Abstract Background: The human gut microbiota has been related to numerous colonic diseases. To identify colorectal cancer (CRC)-associated microbiota, the gut microbiomes of patients with colonic polyps and CRC compared to normal controls were analyzed.Methods: Between July and December 2020, forty-four stool samples were obtained from participants older than 50 years who were scheduled for elective colonoscopies at the Surgery Clinic, Songklanagarind Hospital. The samples were divided into 3 groups (17 normal control, 17 colonic polyps, and 10 CRC) and were collected for analysis with a 16s metagenomic sequencing library preparation with MiSeq Reporter software (MSR) following the protocol of the 16s metagenomics workflow. The microbiome data were analyzed with Kruskal–Wallis test with the Dunn-Bonferroni post hoc method.Results: The relative proportions of beneficial butyrate-producers Kineothrix alysoides, Eubacterium rectale, and Roseburia inulinsivorans were significantly higher in healthy control and colonic polyp groups compared with the CRC group at the top three lowest p-values. The recommended CRC biomarker Clostridium symbiosum was shown in a significantly higher proportion in the CRC group than in the normal control group. The prevalences and relative proportion of the novel CRC-associated species Acutalibacter muris and the familiar CRC-associated species Christensenella massiliensis and lntestinimonas butyriciproducens were significantly higher in the CRC group than in the normal control and colonic polyp groups at the top three lowest p-values.Conclusions: A correlation between specific bacteria and clinical outcomes was found in this pilot study. The microbiome data revealed possible microbial biomarkers associated with CRC. Studies with larger numbers of stool samples are required to substantiate our findings.


2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Wei Wang ◽  
Yihui Hu ◽  
Yanhong Luo ◽  
Xin Wang

Colorectal cancer originates from adenomatous polyps. Adenomatous polyps start out as benign, but over time they can become malignant and even lead to complications and death which will spread to adherent and surrounding organs over time, such as lymph nodes, liver, or lungs, eventually leading to complications and death. Factors such as operator’s experience shortage and visual fatigue will directly affect the diagnostic accuracy of colonoscopy. To relieve the pressure on medical imaging personnel, this paper proposed a network model for colonic polyp detection using colonoscopy images. Considering the unnoticeable surface texture of colonic polyps, this paper designed a channel information interaction perception (CIIP) module. Based on this module, an information interaction perception network (IIP-Net) is proposed. In order to improve the accuracy of classification and reduce the cost of calculation, the network used three classifiers for classification: fully connected (FC) structure, global average pooling fully connected (GAP-FC) structure, and convolution global average pooling (C-GAP) structure. We evaluated the performance of IIP-Net by randomly selecting colonoscopy images from a gastroscopy database. The experimental results showed that the overall accuracy of IIP-NET54-GAP-FC module is 99.59%, and the accuracy of colonic polyp is 99.40%. By contrast, our IIP-NET54-GAP-FC performed extremely well.


Author(s):  
Ishak Pacal ◽  
Ahmet Karaman ◽  
Dervis Karaboga ◽  
Bahriye Akay ◽  
Alper Basturk ◽  
...  

Author(s):  
Sneha R Adidam ◽  
◽  
Seenath M ◽  
Chalapathi R Adidam Venkata ◽  
◽  
...  

Inflammatory Myoglandular polyps (IMGPs) are rare intestinal polyps that occur frequently in the left colon and may present with hematochezia. Only a small number of cases have been reported in the right colon (2%). We present a case of IMGP in the proximal ascending colon. A 46-year-old woman of mixed ethnicity presented with a history of abdomino-pelvic pain and constipation. CT scan suggested possibility of malignancy. On colonoscopy, a non- obstructive polyp in proximal ascending colon was biopsied followed by right hemicolectomy. Patient also underwent total abdominal hysterectomy at the same time for fibroids. The colonic polyp revealed features of IMGP with focal adenomatous changes. The polyp was characterized by epithelial erosion, inflamed granulation tissue, hyperplastic and dilated glands, and proliferating smooth muscle. IMGP needs to be distinguished from other non-neoplastic colonic polyps, which includes Peutz-Jeghers polyps, inflammatory pseudopolyps, juvenile polyps, and inflammatory fibroid polyps. We report a large sized inflammatory myoglandular polyp with suspicious imaging findings and presence of adenomatous changes that mimicked malignancy that requires comprehensive evaluation and follow up.


2021 ◽  
Vol 116 (1) ◽  
pp. S769-S769
Author(s):  
Neha Sharma ◽  
Kaveh Zivari ◽  
Avleen Kaur ◽  
Meredith E. Pittman ◽  
Negar Niknam
Keyword(s):  

2021 ◽  
Vol 116 (1) ◽  
pp. S812-S813
Author(s):  
Nikisha Pandya ◽  
Mohammad Choudhry ◽  
Christopher Chum ◽  
Vera Platsky

2021 ◽  
Vol 116 (1) ◽  
pp. S783-S783
Author(s):  
Grace Hopp ◽  
Tamneet Basra ◽  
Dhruv Mehta ◽  
Apeksha Agarwal

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