Zolmitriptan nasal spray in the acute treatment of cluster headache: A double-blind study

Acute headache is a very frequent symptom, responsible for a significant percentage of caseload at primary care units and emergency rooms. Chlorpromazine is easily available in such settings. The aim of this study is to conduct a randomized, placebo-controlled, double-blind study to assess the efficacy of chlorpromazine on the acute treatment of episodic tension-type headache. We randomized 30 patients to receive placebo (10 ml of saline intravenous injections) and 30 patients to receive 0.1 mg/Kg chlorpromazine intravenously. We used 7 parameters of analgesic evaluation. Patients receiving chlorpromazine showed a statistically significant improvement (p < 0.05 and p < 0.01) of pain compared to placebo, far up to 30 minutes after the drug administration. The therapeutic gain was 36.7% in 30 minutes and 56.6 % in 60 minutes. The number needed to treat (NNT, the reciprocal or the therapeutic gain) was 2.7 in 30 minutes and 1.8 in 60 minutes. There were reductions in the recurrence and in the use of rescue medication in the chlorpromazine group. We can conclude that intravenous chlorpromazine is an effective drug to relief the pain in tension-type headache.

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Effectiveness of Oral Diclofenac in the Acute Treatment of Common Migraine Attacks: A Double-Blind Study Versus Placebo

Cephalalgia ◽

10.1046/j.1468-2982.1991.1102059.x ◽

1991 ◽

Vol 11 (2) ◽

pp. 59-63 ◽

Cited By ~ 25

Author(s):

Hélène Massiou ◽

Dominique Serrurier ◽

Odile Lasserre ◽

Marie-Germaine Bousser

Keyword(s):

Clinical Relevance ◽

Acute Treatment ◽

Migraine Without Aura ◽

International Headache Society ◽

Blind Study ◽

Drug Intake ◽

Double Blind Study ◽

Double Blind ◽

The One

In a multicentre double-blind cross-over trial, oral diclofenac at a dose of 50 mg to 100 mg was compared to placebo in the acute treatment of migraine attacks. A hundred and seven patients suffering from migraine without aura were included, and 91 were analysed for efficacy; they had to treat four successive attacks-two with diclofenac and two with placebo. Diclofenac was significantly more effective than placebo ( p < 0.05) on the main judgement parameter, which was the number of attacks aborted within 2 h of drug intake, as well as on the following secondary parameters: the necessity for an escape medication and the evaluation of global efficacy. Diclofenac was well tolerated. This trial demonstrates the efficacy of diclofenac in the acute treatment of migraine attacks. It confirms the good clinical relevance of the main judgement parameter chosen, which is the one recommended by the International Headache Society, but appears to be a severe one in terms of successes.

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Verapamil in the prophylaxis of episodic cluster headache: A double-blind study versus placebo

Neurology ◽

10.1212/wnl.54.6.1382 ◽

2000 ◽

Vol 54 (6) ◽

pp. 1382-1385 ◽

Cited By ~ 142

Author(s):

M. Leone ◽

D. D'Amico ◽

F. Frediani ◽

F. Moschiano ◽

L. Grazzi ◽

...

Keyword(s):

Cluster Headache ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Episodic Cluster Headache

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A double blind study of triamcinolone acetonide nasal spray in allergic rhinitis

Journal of Allergy ◽

10.1016/0021-8707(62)90056-4 ◽

1962 ◽

Vol 33 (1) ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Ienry T. Friedman

Keyword(s):

Allergic Rhinitis ◽

Triamcinolone Acetonide ◽

Nasal Spray ◽

Blind Study ◽

Double Blind Study ◽

Double Blind

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Salmon calcitonin (injection and nasal spray) and placebo in patients undergoing total hip replacement: A double-blind study

Current Therapeutic Research ◽

10.1016/s0011-393x(05)80157-2 ◽

1993 ◽

Vol 53 (1) ◽

pp. 67-76

Author(s):

R. Dolecek ◽

J. Mikula ◽

B. Skwarlo ◽

Z. Sturc ◽

J. Machalek

Keyword(s):

Total Hip Replacement ◽

Nasal Spray ◽

Salmon Calcitonin ◽

Hip Replacement ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Total Hip

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Beclomethasone nasal spray in the treatment of middle-ear effusion — a double-blind study

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/0165-5876(82)90088-x ◽

1982 ◽

Vol 4 (2) ◽

pp. 133-137 ◽

Cited By ~ 16

Author(s):

Torben Lildholdt ◽

Birger Kortholm

Keyword(s):

Nasal Spray ◽

Middle Ear ◽

Blind Study ◽

Double Blind Study ◽

Middle Ear Effusion ◽

Double Blind ◽

Ear Effusion

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Sexual Impotence: a Double-Blind Study of LHRH Nasal Spray versus Placebo

Neuropsychobiology ◽

10.1159/000117495 ◽

1975 ◽

Vol 1 (4) ◽

pp. 203-210 ◽

Cited By ~ 17

Author(s):

O. Benkert ◽

R. Jordan ◽

H.G. Dahlen ◽

H.P.G. Schneider ◽

G. Gammel

Keyword(s):

Nasal Spray ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Sexual Impotence

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A Double-Blind Study of Ibuprofen Versus Placebo in the Treatment of Acute Migraine Attacks

Cephalalgia ◽

10.1046/j.1468-2982.1992.1203169.x ◽

1992 ◽

Vol 12 (3) ◽

pp. 169-171 ◽

Cited By ~ 51

Author(s):

Reidar Kloster ◽

Knut Nestvold ◽

Steinar T Vilming

Keyword(s):

Side Effects ◽

Initial Dose ◽

Acute Treatment ◽

Blind Study ◽

Double Blind Study ◽

Acute Migraine ◽

Double Blind ◽

Double Blind Placebo ◽

Inflammatory Drug ◽

Anti Inflammatory

The efficacy of ibuprofen, a non-steroidal anti-inflammatory drug, was assessed in the acute treatment of migraine. Twenty-five patients completed a double-blind placebo-controlled multicrossover trial. The initial dose of ibuprofen was 1200 mg. Six migraine attacks were randomly treated in each patient, three with ibuprofen and three with placebo. The results indicated a statistically significant reduction in the duration of the migraine attacks and also a statistically significant reduction in the severity of headache and nausea in the ibuprofen-treated attacks. The use of additional medication was significantly reduced in the ibuprofen-treated attacks (25.6% vs 57.5%), No serious side effects were reported. Ibuprofen is valuable in the treatment of acute migraine attacks.

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