Delayed Epidural Hemorrhage in Hypotensive Multiple Trauma Patients

Abstract Despite the availability of high resolution computed tomography, severely head-injured patients often present diagnostic dilemmas. An initially negative computed tomographic scan in the presence of severe multiple trauma does not predict an uncomplicated course. Early repeat scanning should be considered. We present three cases of delayed epidural hemorrhage in multiple trauma patients who initially were hypotensive secondary to hypovolemia. Possible etiologies for the hemorrhage as well as a list of indications for repeat scanning in the posttraumatic period are discussed.

Download Full-text

Oxygen Delivery and Consumption in Head-Injured and Multiple Trauma Patients

Survey of Anesthesiology ◽

10.1097/00132586-199106000-00005 ◽

1991 ◽

Vol 35 (3) ◽

pp. 129

Author(s):

P. J. FEUSTEL ◽

J. B. FORTUNE ◽

H. STRATTON ◽

J. C. NEWELL

Keyword(s):

Multiple Trauma ◽

Oxygen Delivery ◽

Trauma Patients ◽

Head Injured ◽

Multiple Trauma Patients

Download Full-text

Prehospital Administration of Mannitol in Head-Injured, Multiple Trauma Patients

Prehospital and Disaster Medicine ◽

10.1017/s1049023x00049761 ◽

1993 ◽

Vol 8 (S2) ◽

pp. S64-S64

Author(s):

M.R Sayre ◽

S Dailey ◽

S Stern ◽

D.L Storer ◽

H Van Loveren ◽

...

Keyword(s):

Multiple Trauma ◽

Trauma Patients ◽

Head Injured ◽

Multiple Trauma Patients

Download Full-text

The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma

Mediators of Inflammation ◽

10.1155/2014/303106 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Tim Klüter ◽

Stefanie Fitschen-Oestern ◽

Sebastian Lippross ◽

Matthias Weuster ◽

Rolf Mentlein ◽

...

Keyword(s):

Antimicrobial Peptide ◽

Multiple Trauma ◽

Trauma Patients ◽

Serum Samples ◽

Related Factors ◽

Tissue Samples ◽

Multiple Injured ◽

Multiple Trauma Patients ◽

Injured Patients ◽

Multiple Injured Patients

The antimicrobial peptide lysozyme is an important factor of innate immunity and exerts high potential of antibacterial activity. In the present study we evaluated the lysozyme expression in serum of multiple injured patients and subsequently analyzed their possible sources and signaling pathways. Expression of lysozyme was examined in blood samples of multiple trauma patients from the day of trauma until 14 days after trauma by ELISA. To investigate major sources of lysozyme, its expression and regulation in serum samples, different blood cells, and tissue samples were analysed by ELISA and real-time PCR. Neutrophils and hepatocytes were stimulated with cytokines and supernatant ofStaphylococcus aureus. The present study demonstrates the induction and release of lysozyme in serum of multiple injured patients. The highest lysozyme expression of all tested cells and tissues was detected in neutrophils. Stimulation with trauma-related factors such as interleukin-6 andS. aureusinduced lysozyme expression. Liver tissue samples of patients without trauma show little lysozyme expression compared to neutrophils. After stimulation with bacterial fragments, lysozyme expression of hepatocytes is upregulated significantly. Toll-like receptor 2, a classic receptor of Gram-positive bacterial protein, was detected as a possible target for lysozyme induction.

Download Full-text