scholarly journals Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration

2006 ◽  
Vol 119 (13) ◽  
pp. 2679-2687 ◽  
Author(s):  
T. Yokota
Keyword(s):  
Muscle Regeneration ◽  
Precursor Cells ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

Incorporation of donor muscle precursor cells into an area of muscle regeneration in the host mouse

1982 ◽  
Vol 57 (2-3) ◽  
pp. 319-331 ◽  
Author(s):  
D.J. Watt ◽  
K. Lambert ◽  
J.E. Morgan ◽  
T.A. Partridge ◽  
J.C. Sloper
Keyword(s):  
Muscle Regeneration ◽  
Precursor Cells ◽  
Muscle Precursor ◽  
Host Mouse ◽  
Donor Muscle ◽  
Muscle Precursor Cells

1071 Muscle regeneration and tracking of human muscle precursor cells by MRI in vivo

2012 ◽  
Vol 11 (1) ◽  
pp. e1071-e1071a
Author(s):  
F. Azzabi ◽  
V. Jovaisaite ◽  
J. Njiwa ◽  
A. Boss ◽  
R. Rudin ◽  
...  
Keyword(s):  
Muscle Regeneration ◽  
Precursor Cells ◽  
Human Muscle ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

Human Muscle Precursor Cells Form Human-Derived Myofibers in Skeletal Muscles of Nonhuman Primates: A Potential New Preclinical Setting to Test Myogenic Cells of Human Origin for Cell Therapy of Myopathies

2020 ◽  
Vol 79 (12) ◽  
pp. 1265-1275
Author(s):  
Daniel Skuk ◽  
Jacques P Tremblay
Keyword(s):  
Muscle Regeneration ◽  
De Novo ◽  
Lymphocytic Infiltration ◽  
Precursor Cells ◽  
Human Muscle ◽  
Myogenic Cells ◽  
Cell Therapies ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

Abstract This study aimed to verify if human myogenic cells could participate in muscle regeneration in macaques. This experimental setting would grant researchers a model that could better evaluate the effects of cell therapies in myopathies with a better translation to human patients. Human muscle precursor cells (MPCs) were cultured in vitro and transduced with ß-galactosidase. The cells were subsequently injected into 1-cm3 muscle regions of 6 macaques immunosuppressed with tacrolimus and dexamethasone. Allogeneic ß-galactosidase+ MPCs were injected in other regions as positive controls. Some cell-grafted regions were electroporated to induce extensive muscle regeneration. MPC-grafted regions were sampled 1 month later and analyzed by histology. There were ß-galactosidase+ myofibers in both the regions grafted with human and macaque MPCs. Electroporation increased the engraftment of human MPCs in the same way as in macaque allografts. The histological analysis (hematoxylin and eosin, CD8, and CD4 immunodetection) demonstrated an absence of cellular rejection in most MPC-grafted regions, as well as minimal lymphocytic infiltration in the regions transplanted with human MPCs in the individual with the lowest tacrolimus levels. Circulating de novo anti-donor antibodies were not detected. In conclusion, we report the successful engraftment of human myogenic cells in macaques, which was possible using tacrolimus-based immunosuppression.

Implanted myoblasts not only fuse with myofibers but also survive as muscle precursor cells

1993 ◽  
Vol 105 (4) ◽  
pp. 957-963 ◽  
Author(s):  
S.N. Yao ◽  
K. Kurachi
Keyword(s):  
Gene Transfer ◽  
Muscle Regeneration ◽  
Precursor Cells ◽  
Additional Mechanism ◽  
Myogenic Cells ◽  
Muscle Precursor ◽  
Primary Myoblasts ◽  
Muscle Precursor Cells

Intramuscular implanted myoblasts can fuse with existing myofibers. Here we report that implanted primary myoblasts marked with retroviral transgenes can also persist as muscle precursor cells. These cells can be recovered as viable myoblasts from muscles of recipient mice even months after myoblast implantation, and they can fully resume expression of the transgenes in culture. Upon re-implantation into muscles, they again not only fuse with existing myofibers, but also survive as muscle precursor cells in the tissue. These reserve myogenic cells should be able to contribute to host myofibers in muscle regeneration when the recombinant myofibers are damaged, providing an additional mechanism to maintain a persistent expression of transgenes delivered by myoblast-mediated gene transfer.

204 MUSCLE REGENERATION AND TRACKING OF HUMAN MUSCLE PRECURSOR CELLS BY MRI IN VIVO

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Fahd Azzabi ◽  
Virginija Jovaisaite ◽  
Andreas Boss ◽  
Josiane Njiwa ◽  
Markus Rudin ◽  
...  
Keyword(s):  
Muscle Regeneration ◽  
Precursor Cells ◽  
Human Muscle ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

506: Restoration of Innervated Urinary Sphincter Function Using Muscle Precursor Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 135-135
Author(s):  
Rene Yiou ◽  
James J. Yoo ◽  
Anthony Atala
Keyword(s):  
Precursor Cells ◽  
Sphincter Function ◽  
Muscle Precursor ◽  
Urinary Sphincter ◽  
Muscle Precursor Cells

scholarly journals Fibroblast growth factor 2-stimulated proliferation is lower in muscle precursor cells from old rats

2009 ◽  
Vol 94 (6) ◽  
pp. 739-748 ◽  
Author(s):  
Seth S. Jump ◽  
Tom E. Childs ◽  
Kevin A. Zwetsloot ◽  
Frank W. Booth ◽  
Simon J. Lees
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Precursor Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Muscle Precursor ◽  
Old Rats ◽  
Muscle Precursor Cells
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