scholarly journals Hif-1α paralogs play a role in the hypoxic ventilatory response of larval and adult zebrafish (Danio rerio)

2018 ◽  
Vol 222 (2) ◽  
pp. jeb195198 ◽  
Author(s):  
Milica Mandic ◽  
Velislava Tzaneva ◽  
Vincent Careau ◽  
Steve F. Perry
Keyword(s):  
Danio Rerio ◽  
Ventilatory Response ◽  
Hypoxic Ventilatory Response ◽  
Adult Zebrafish

scholarly journals Relationships between the peak hypoxic ventilatory response and critical O2 tension in larval and adult zebrafish (Danio rerio)

2020 ◽  
Vol 223 (7) ◽  
pp. jeb213942 ◽  
Author(s):  
Milica Mandic ◽  
Yihang K. Pan ◽  
Kathleen M. Gilmour ◽  
Steve F. Perry
Keyword(s):  
Danio Rerio ◽  
Ventilatory Response ◽  
Hypoxic Ventilatory Response ◽  
Adult Zebrafish

scholarly journals The role of TASK-2 channels in CO2 sensing in zebrafish (Danio rerio)

2020 ◽  
Vol 319 (3) ◽  
pp. R329-R342
Author(s):  
N. Koudrina ◽  
S. F. Perry ◽  
K. M. Gilmour
Keyword(s):  
Danio Rerio ◽  
Ventilatory Response ◽  
Indirect Evidence ◽  
Adult Zebrafish ◽  
Larval Zebrafish ◽  
Neuroepithelial Cells ◽  
Cardiorespiratory Reflexes ◽  
Or Task ◽  
And Task

Peripheral chemosensitivity in fishes is thought to be mediated by serotonin-enriched neuroepithelial cells (NECs) that are localized to the gills of adults and the integument of larvae. In adult zebrafish ( Danio rerio), branchial NECs are presumed to mediate the cardiorespiratory reflexes associated with hypoxia or hypercapnia, whereas in larvae, there is indirect evidence linking cutaneous NECs to hypoxic hyperventilation and hypercapnic tachycardia. No study yet has examined the ventilatory response of larval zebrafish to hypercapnia, and regardless of developmental stage, the signaling pathways involved in CO2 sensing remain unclear. In the mouse, a background potassium channel (TASK-2) contributes to the sensitivity of chemoreceptor cells to CO2. Zebrafish possess two TASK-2 channel paralogs, TASK-2 and TASK-2b, encoded by kcnk5a and kcnk5b, respectively. The present study aimed to determine whether TASK-2 channels are expressed in NECs of larval zebrafish and whether they are involved in CO2 sensing. Using immunohistochemical approaches, TASK-2 protein was observed on the surface of NECs in larvae. Exposure of larvae to hypercapnia caused cardiac and breathing frequencies to increase, and these responses were blunted in fish experiencing TASK-2 and/or TASK-2b knockdown. The results of these experiments suggest that TASK-2 channels are involved in CO2 sensing by NECs and contribute to the initiation of reflex cardiorespiratory responses during exposure of larvae to hypercapnia.

Axonal projections originating from raphe serotonergic neurons in the developing and adult zebrafish,Danio rerio, using transgenics to visualize raphe-specificpet1expression

2009 ◽  
Vol 512 (2) ◽  
pp. 158-182 ◽  
Author(s):  
Christina Lillesaar ◽  
Christian Stigloher ◽  
Birgit Tannhäuser ◽  
Mario F. Wullimann ◽  
Laure Bally-Cuif
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Serotonergic Neurons ◽  
Axonal Projections

scholarly journals Different action mechanisms of low- and high-level quercetin in the brains of adult zebrafish (Danio rerio)

2021 ◽  
Vol 223 ◽  
pp. 112597
Author(s):  
Xia Wu ◽  
Li-Jun Wang ◽  
Yu Hou ◽  
Rui-Ying Guo ◽  
Min Liu ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Action Mechanisms ◽  
High Level

scholarly journals Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca2+ -dependent P2Y1 receptor mechanism

2017 ◽  
Vol 596 (15) ◽  
pp. 3245-3269 ◽  
Author(s):  
Vishaal Rajani ◽  
Yong Zhang ◽  
Venkatesh Jalubula ◽  
Vladimir Rancic ◽  
Shahriar SheikhBahaei ◽  
...  
Keyword(s):  
Ventilatory Response ◽  
P2y1 Receptor ◽  
Hypoxic Ventilatory Response ◽  
Bötzinger Complex

Methysergide augments the acute, but not the sustained, hypoxic ventilatory response in goats

1999 ◽  
Vol 118 (1) ◽  
pp. 25-37 ◽  
Author(s):  
Jay K. Herman ◽  
Ken D. O’Halloran ◽  
Gordon S. Mitchell ◽  
Gerald E. Bisgard
Keyword(s):  
Ventilatory Response ◽  
Hypoxic Ventilatory Response

scholarly journals Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure

2009 ◽  
Vol 337 (1) ◽  
pp. 45-61 ◽  
Author(s):  
Marie-Claude Senut ◽  
Seema Azher ◽  
Frank L. Margolis ◽  
Kamakshi Patel ◽  
Ahmad Mousa ◽  
...  
Keyword(s):  
Nervous System ◽  
Danio Rerio ◽  
Adult Zebrafish

scholarly journals Chronic intermittent hyperoxia alters the development of the hypoxic ventilatory response in neonatal rats

2016 ◽  
Vol 220 ◽  
pp. 69-80 ◽  
Author(s):  
Sarah Logan ◽  
Kristina E. Tobin ◽  
Sarah C. Fallon ◽  
Kevin S. Deng ◽  
Amy B. McDonough ◽  
...  
Keyword(s):  
Ventilatory Response ◽  
Neonatal Rats ◽  
Hypoxic Ventilatory Response
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