scholarly journals Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas.

1981 ◽  
Vol 4 (6) ◽  
pp. 410-417 ◽  
Author(s):  
MASAYASU KIMURA ◽  
ISAMI WAKI ◽  
TADASHI CHUJO ◽  
TAKEO KIKUCHI ◽  
CHIZUKO HIYAMA ◽  
...  
Keyword(s):  
Insulin Release ◽  
Insulin Level ◽  
Diabetic Mice ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Blood Insulin

Effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas

Diabetes ◽  
1981 ◽  
Vol 30 (2) ◽  
pp. 168-171 ◽  
Author(s):  
M. S. Robbins ◽  
L. H. Grouse ◽  
R. L. Sorenson ◽  
R. P. Elde
Keyword(s):  
Insulin Release ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

STUDIES ON THE MECHANISM OF SOMATOSTATIN ACTION ON INSULIN RELEASE

1977 ◽  
Vol 85 (3) ◽  
pp. 579-586 ◽  
Author(s):  
S. Efendić ◽  
P. E. Lins ◽  
R. Luft ◽  
H. Sievertsson ◽  
G. Westin-Sjödal
Keyword(s):  
Amino Acids ◽  
Insulin Release ◽  
Cyclic Peptide ◽  
The Other ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Amino Terminal ◽  
Structure Activity ◽  
Carboxyl Terminal ◽  
Relationship Of

ABSTRACT Eighteen analogues of somatostatin have been used in order to elucidate the structure-activity relationship of the peptide on the release of insulin and glucagon from the isolated perfused rat pancreas. Neither the amino terminal nor a free carboxyl terminal seemed to be essential for the activity of the cyclic peptide. Addition of amino acids to the amino terminal did not decrease the activity. On the other hand, minor changes in the structure of linear somatostatin, which lead to the loss of ability to form a cyclic peptide, impaired the activity. Deletion of Asn5 was accompanied by decreased action on glucagon but not on insulin release. It seems that the major actions of somatostatin on the pancreas are bound to the amino acid sequence 4–13 in the molecule and to the ability of the molecule to cyclize.

Effect of glucagon antiserum on somatostatin, glucagon and insulin release from the isolated perfused rat pancreas

Peptides ◽  
1982 ◽  
Vol 3 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Susumu Seino ◽  
Hideo Sakurai ◽  
Hideshi Kuzuya ◽  
Kinsuke Tsuda ◽  
Keiichiro Tanigawa ◽  
...  
Keyword(s):  
Insulin Release ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Glucagon And Insulin

Proglumide Analogues CR 1409 and CR 1392 Inhibit Cholecystokinin-Stimulated Insulin Release More Potently Than Exocrine Secretion from the Isolated Perfused Rat Pancreas

Pancreas ◽  
1990 ◽  
Vol 5 (3) ◽  
pp. 291-297 ◽  
Author(s):  
Yoshinori Okabayashi ◽  
Makoto Otsuki ◽  
Takahiko Nakamura ◽  
Masatoshi Fujii ◽  
Satoshi Tani ◽  
...  
Keyword(s):  
Insulin Release ◽  
Exocrine Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

scholarly journals Glucose Modulation of Amino Acid-Induced Glucagon and Insulin Release in the Isolated Perfused Rat Pancreas

1974 ◽  
Vol 54 (4) ◽  
pp. 819-832 ◽  
Author(s):  
Anthony S. Pagliara ◽  
Susan N. Stillings ◽  
Barbara Hover ◽  
Duane M. Martin ◽  
Franz M. Matschinsky
Keyword(s):  
Amino Acid ◽  
Insulin Release ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Glucagon And Insulin

Stimulatory effect of bradykinin on insulin release from the perfused rat pancreas

1995 ◽  
Vol 268 (5) ◽  
pp. E1027-E1030
Author(s):  
C. Yang ◽  
W. H. Hsu
Keyword(s):  
Receptor Antagonist ◽  
Insulin Release ◽  
Glucose Concentration ◽  
Physiological Role ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Perfused Rat Pancreas ◽  
Pancreas Perfusion ◽  
Rat Pancreas ◽  
Hoe 140

Rat pancreas perfusion was performed to study the effect of bradykinin on insulin release. At the perfusate glucose concentration of 6 mM, bradykinin (0.01-1 microM) increased insulin release in a concentration-dependent manner. In addition, bradykinin (1 microM) increased the glucose (10 mM)-induced insulin release. HOE-140 (0.1 microM), a bradykinin B2-receptor antagonist, decreased the baseline insulin release and abolished the bradykinin (1 microM)-induced increase in insulin release. In addition, HOE-140 (0.1 microM) attenuated the glucose (10 mM)-induced increase in insulin release. Because the blockade of bradykinin receptors by HOE-140 attenuated the glucose-induced increased insulin release, our present findings suggest that bradykinin may play a physiological role in the regulation of insulin release.

Sign in / Sign up

Export Citation Format

Share Document