scholarly journals 3-Trifluoromethylcephalosporins. I. Total synthesis of tert-butyl (.+-.)-7-amino-3-trifluoromethyl-3-cephem-4-carboxylate.

1980 ◽  
Vol 28 (1) ◽  
pp. 62-69 ◽  
Author(s):  
TAIICHIRO WATANABE ◽  
YOICHI KAWANO ◽  
TERUO TANAKA ◽  
TOSHIHIKO HASHIMOTO ◽  
TETSUO MIYADERA
Keyword(s):  
Total Synthesis ◽  
Tert Butyl

Synthesis of Optically Active Hydroxyalkyl Cycloheptatrienes: A Key Step in the Total Synthesis of 6,11-Methylene-LXB4

Synlett ◽  
2020 ◽  
Vol 32 (01) ◽  
pp. 45-50
Author(s):  
Udo Nubbemeyer ◽  
Analuisa Nava ◽  
Lukas Trippe ◽  
Andrea Frank ◽  
Lars Andernach ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Total Synthesis ◽  
Structure Elucidation ◽  
Butyl Ester ◽  
Optically Active ◽  
Chiral Hplc ◽  
Reaction Conditions ◽  
Acid Product ◽  
Tert Butyl ◽  
Nabh4 Reduction

AbstractStarting from methyl cycloheptatrienyl-1-carboxylate, 6-acylation was successfully achieved employing glutaryl chloride in the presence of AlCl3 under controlled reaction conditions to furnish keto carboxylic acid product. After protection of this keto carboxylic acid as tert-butyl ester, reagent-controlled enantioselective reductions delivered configuration-defined methyl-6-hydroxylalkyl cycloheptatriene-1-carboxylates with up to 80% ee. Whereas simple NaBH4 reduction of the keto carboxylic acid and subsequent lactonization afforded a methyl-6-tetrahydropyranonyl cycloheptatriene-1-carboxylate. Resolution using chiral HPLC delivered the product enantiomers with up to >99% ee Finally, ECD analyses enabled structure elucidation. The products are used as key intermediates in enantioselective 6,11-methylene-lipoxin B4 syntheses.

Thiol esters in organic synthesis. XIV. The total synthesis of racemic α-costal

1986 ◽  
Vol 64 (4) ◽  
pp. 658-666 ◽  
Author(s):  
Hsing-Jang Liu ◽  
Hla Wynn
Keyword(s):  
Total Synthesis ◽  
Organic Synthesis ◽  
Salient Feature ◽  
Tert Butyl ◽  
Racemic Form ◽  
Thiol Esters

The first total synthesis of α-costal (1) in racemic form has been achieved in an unequivocal manner whereby the structure previously assigned to the natural aldehyde is confirmed. A salient feature of the synthesis is the use of S-tert-butyl cyanothiolacetate to facilitate the introduction of the labile acrolein unit.

Absolute configuration of A-32'287 [conocandin] and total synthesis of its methyl and tert-butyl esters

1987 ◽  
Vol 52 (24) ◽  
pp. 5452-5457 ◽  
Author(s):  
Luca Banfi ◽  
Walter Cabri ◽  
Giovanni Poli ◽  
Donatella Potenza ◽  
Carlo Scolastico
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
Tert Butyl ◽  
Butyl Esters

Total synthesis of indole and dihydroindole alkaloids. XII. Selective functionalization of various bisindoles. Efficient syntheses of leurosine and related bisindole alkaloid derivatives

1978 ◽  
Vol 56 (1) ◽  
pp. 62-70 ◽  
Author(s):  
James P. Kutney ◽  
John Balsevich ◽  
Gordon H. Bokelman ◽  
Toshihiko Hibino ◽  
Toshio Honda ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Osmium Tetroxide ◽  
Mercuric Acetate ◽  
Efficient Procedure ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Selective Functionalization ◽  
Tert Butyl Hydroperoxide ◽  
Acidic Conditions ◽  
Synthetic Derivatives

Studies involving selective functionalization of the indole unit in a number of bisindole alkaloids and related synthetic derivatives are described. These investigations include such reagents as tert-butyl hydroperoxide, which provides an efficient procedure for epoxidation of olefinic linkages, mercuric acetate, osmium tetroxide, and iodine under basic conditions and oxygenation under acidic conditions. Efficient syntheses of leurosine (8) and various novel vinblastine derivatives are developed.

ChemInform Abstract: Absolute Configuration of A-32′287 (Conocandin) and Total Synthesis of Its Methyl and tert-Butyl Esters.

ChemInform ◽  
1988 ◽  
Vol 19 (17) ◽  
Author(s):  
L. BANFI ◽  
W. CABRI ◽  
G. POLI ◽  
D. POTENZA ◽  
C. SCOLASTICO
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
Tert Butyl ◽  
Butyl Esters

Total synthesis of two isoflavone C-glycosides (6-tert-butyl puerarin and 6-tert-butyl-4′-methoxypuerarin) through the deoxybenzoin pathway

2017 ◽  
Vol 58 (29) ◽  
pp. 2835-2837 ◽  
Author(s):  
Yunpeng Zou ◽  
Shouguo Zhang ◽  
Xiaoxue Wen ◽  
Gang wang ◽  
Yunbo sun ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Tert Butyl

scholarly journals Totalsynthese von Thymosin /β4, 3[1,2] Klassische Synthese des Fragments [31 -43] von Thymosin ß4 / Total Synthesis of Thymosin β4, 3[1, 2] Conventional Synthesis of the Fragment [31-43] of Thymosin β4

1993 ◽  
Vol 48 (7) ◽  
pp. 1000-1008 ◽  
Author(s):  
Peter Link ◽  
Wolfgang Voelter
Keyword(s):  
Total Synthesis ◽  
Side Chain ◽  
Thymosin Β4 ◽  
Terminal Part ◽  
Tert Butyl ◽  
Peptide Derivative

As part of our total synthesis of thymosin β4 an optimized synthesis of the C-terminal part of thymosin β4 is described. Side chain functional residues of the tridecapeptide are masked by tert-butyl and the α-amino residues are protected by Z groups. The fully protected peptide derivative was obtained by WSCI/HOBt coupling of three fragments representing the segments [31-35], [36-37] and [38-43].

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