Totalsynthese von Thymosin /β4, 3[1,2] Klassische Synthese des Fragments [31 -43] von Thymosin ß4 / Total Synthesis of Thymosin β4, 3[1, 2] Conventional Synthesis of the Fragment [31-43] of Thymosin β4

As part of our total synthesis of thymosin β4 an optimized synthesis of the C-terminal part of thymosin β4 is described. Side chain functional residues of the tridecapeptide are masked by tert-butyl and the α-amino residues are protected by Z groups. The fully protected peptide derivative was obtained by WSCI/HOBt coupling of three fragments representing the segments [31-35], [36-37] and [38-43].