Syntheses and Biological Evaluation of Novel Hydroxamic Acid Derivatives Containing Purine Moiety as Histone Deacetylase Inhibitors

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c17-00997 ◽

2018 ◽

Vol 66 (4) ◽

pp. 439-451

Author(s):

Zhaoxing Xu ◽

Yongchao Yang ◽

Xi Mai ◽

Bin Liu ◽

Yuanzhen Xiong ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, synthesis, and biological evaluation of indole-based hydroxamic acid derivatives as histone deacetylase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113893 ◽

2022 ◽

Vol 227 ◽

pp. 113893

Author(s):

Bei-Er Jiang ◽

Jiaxin Hu ◽

Hao Liu ◽

Zhitao Liu ◽

Yu Wen ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.08.030 ◽

2014 ◽

Vol 22 (21) ◽

pp. 6146-6155 ◽

Author(s):

Wei Yang ◽

Lixuan Li ◽

Xun Ji ◽

Xiaowei Wu ◽

Mingbo Su ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Hydroxamic acid derivatives as histone deacetylase inhibitors: a DFT study of their tautomerism and metal affinities/selectivities

Journal of Molecular Modeling ◽

10.1007/s00894-018-3651-6 ◽

2018 ◽

Vol 24 (5) ◽

Author(s):

D. Cheshmedzhieva ◽

N. Toshev ◽

M. Gerova ◽

O. Petrov ◽

T. Dudev

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Dft Study ◽

Hydroxamic Acid Derivatives

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Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.04.032 ◽

2012 ◽

Vol 20 (12) ◽

pp. 3865-3872 ◽

Author(s):

Peng Guan ◽

Feng’e Sun ◽

Xuben Hou ◽

Feng Wang ◽

Fan Yi ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Design Synthesis ◽

Hydroxamic Acid Derivatives

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Development of Tetrahydroisoquinoline-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities

Journal of Medicinal Chemistry ◽

10.1021/jm101605z ◽

2011 ◽

Vol 54 (8) ◽

pp. 2823-2838 ◽

Author(s):

Yingjie Zhang ◽

Jinhong Feng ◽

Yuping Jia ◽

Xuejian Wang ◽

Lei Zhang ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Antitumor Activities ◽

Hydroxamic Acid Derivatives

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Synthesis, Biological Evaluation, and Computer-Aided Drug Designing of New Derivatives of Hyperactive Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitors

Chemical Biology & Drug Design ◽

10.1111/cbdd.12554 ◽

2015 ◽

Vol 86 (4) ◽

pp. 795-804 ◽

Author(s):

Song Zhang ◽

Weibin Huang ◽

Xiaonan Li ◽

Zhicheng Yang ◽

Binghong Feng

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Biological Evaluation ◽

Suberoylanilide Hydroxamic Acid ◽

Computer Aided ◽

Drug Designing ◽

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Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.01.045 ◽

2014 ◽

Vol 22 (5) ◽

pp. 1529-1538 ◽

Author(s):

Leiqiang Han ◽

Lei Wang ◽

Xuben Hou ◽

Huansheng Fu ◽

Weiguo Song ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Design Synthesis ◽

Hydroxamic Acid Derivatives

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Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.05.089 ◽

2019 ◽

Vol 178 ◽

pp. 116-130 ◽

Author(s):

Zhuang Yang ◽

Mingsheng Shen ◽

Minghai Tang ◽

Wanhua Zhang ◽

Xue Cui ◽

...

Keyword(s):

Cancer Therapy ◽

Histone Deacetylase ◽

Potential Application ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Hydroxamic Acid Derivatives

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Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b00579 ◽

2016 ◽

Vol 59 (11) ◽

pp. 5488-5504 ◽

Author(s):

Yong Chen ◽

Xiaoyan Wang ◽

Wei Xiang ◽

Lin He ◽

Minghai Tang ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Antitumor Activities ◽

Hydroxamic Acid Derivatives

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A Structural Insight into Hydroxamic Acid Based Histone Deacetylase Inhibitors for the Presence of Anticancer Activity

Current Medicinal Chemistry ◽

10.2174/09298673113209990191 ◽

2013 ◽

Vol 21 (23) ◽

pp. 2642-2664 ◽

Author(s):

H. Rajak ◽

A. Singh ◽

K. Raghuwanshi ◽

R. Kumar ◽

P.K. Dewangan ◽

...

Keyword(s):

Anticancer Activity ◽

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Structural Insight ◽

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